Diagnostic performance of stand-alone D-dimer vs other strategies (n = 1397)
| . | D-dimer . | Age-adjusted DD+ . | C-PTP adjusted DD+ . | ||
|---|---|---|---|---|---|
| ≥0.5 mg/L . | or Wells score ≥3 . | or Wells score ≥2 . | |||
| Positive predictive value,*n | 278/982 | 279/1024 | 279/1105 | 273/928 | 271/917 |
| Estimate, % | 28.3 | 27.2 | 25.2 | 29.4 | 29.6 |
| 95% CI | 25.5-31.2 | 24.5-30.1 | 22.7-27.9 | 26.5-32.5 | 26.6-32.6 |
| VTE within 3 mo despite negative workup,†n | 3/415 | 2/371 | 2/290 | 8/469 | 10/480 |
| Estimate, % | 0.7 | 0.5 | 0.7 | 1.7 | 2.1 |
| 95% CI | 0.1-2.1 | 0.1-1.9 | 0.1-2.5 | 0.7-3.3 | 1.0-3.8 |
| Required D-dimer tests according to strategy,‡n | 1397/1397 | 1053/1397 | 699/1397 | 1053/1397 | 1053/1397 |
| Estimate, % | 100 | 75.3 | 50.0 | 75.4 | 75.4 |
| 95% CI | 99.7-100 | 73.0-77.6 | 47.4-52.7 | 73.0-77.6 | 73.0-77.6 |
| Required CUS examinations according to strategy,§n | 982/1397 | 1024/1397 | 1105/1397 | 928/1397 | 917/1397 |
| Estimate, % | 70.3 | 73.3 | 79.1 | 66.4 | 65.6 |
| 95% CI | 67.8-72.7 | 70.9-75.6 | 76.9-81.2 | 63.9-68.9 | 63.1-68.1 |
| . | D-dimer . | Age-adjusted DD+ . | C-PTP adjusted DD+ . | ||
|---|---|---|---|---|---|
| ≥0.5 mg/L . | or Wells score ≥3 . | or Wells score ≥2 . | |||
| Positive predictive value,*n | 278/982 | 279/1024 | 279/1105 | 273/928 | 271/917 |
| Estimate, % | 28.3 | 27.2 | 25.2 | 29.4 | 29.6 |
| 95% CI | 25.5-31.2 | 24.5-30.1 | 22.7-27.9 | 26.5-32.5 | 26.6-32.6 |
| VTE within 3 mo despite negative workup,†n | 3/415 | 2/371 | 2/290 | 8/469 | 10/480 |
| Estimate, % | 0.7 | 0.5 | 0.7 | 1.7 | 2.1 |
| 95% CI | 0.1-2.1 | 0.1-1.9 | 0.1-2.5 | 0.7-3.3 | 1.0-3.8 |
| Required D-dimer tests according to strategy,‡n | 1397/1397 | 1053/1397 | 699/1397 | 1053/1397 | 1053/1397 |
| Estimate, % | 100 | 75.3 | 50.0 | 75.4 | 75.4 |
| 95% CI | 99.7-100 | 73.0-77.6 | 47.4-52.7 | 73.0-77.6 | 73.0-77.6 |
| Required CUS examinations according to strategy,§n | 982/1397 | 1024/1397 | 1105/1397 | 928/1397 | 917/1397 |
| Estimate, % | 70.3 | 73.3 | 79.1 | 66.4 | 65.6 |
| 95% CI | 67.8-72.7 | 70.9-75.6 | 76.9-81.2 | 63.9-68.9 | 63.1-68.1 |
DD, D-dimer.
Number of DVT in all patients requiring workup according to each strategy; true positive/true positive + false positive.
According to the criteria ruling out DVT in each strategy; false negative/false negative + true negative.
Required in all patients or non–high-risk patients.
Required if positive D-dimer or high-risk patients.