AEs (≥15%) for patients in part 1 (N = 12)
| Preferred term . | All grades, n (%) . | Grade ≥3, n (%) . |
|---|---|---|
| Cough | 5 (41.7) | 0 |
| Neutropenia | 5 (41.7) | 2 (16.7) |
| Upper respiratory tract infection | 4 (33.3) | 0 |
| Contusion | 3 (25) | 0 |
| Dyspnea | 3 (25) | 1 (8.3) |
| Fatigue | 3 (25) | 0 |
| Peripheral swelling | 3 (25) | 1 (8.3) |
| Petechiae | 3 (25) | 0 |
| Abdominal distension | 2 (16.7) | 0 |
| Arthralgia | 2 (16.7) | 0 |
| Basal cell carcinoma | 2 (16.7) | 0 |
| Chronic obstructive pulmonary disease | 2 (16.7) | 1 (8.3) |
| Electrocardiogram QT prolonged | 2 (16.7) | 1 (8.3) |
| Epistaxis | 2 (16.7) | 0 |
| Gastroesophageal reflux disease | 2 (16.7) | 0 |
| Nausea | 2 (16.7) | 0 |
| Nephrolithiasis | 2 (16.7) | 1 (8.3) |
| Edema peripheral | 2 (16.7) | 0 |
| Oral herpes | 2 (16.7) | 0 |
| Pruritus | 2 (16.7) | 0 |
| Rhinitis allergic | 2 (16.7) | 0 |
| Sinusitis | 2 (16.7) | 0 |
| Squamous cell carcinoma of skin | 2 (16.7) | 0 |
| Thrombocytopenia | 2 (16.7) | 1 (8.3) |
| Urinary tract infection | 2 (16.7) | 1 (8.3) |
| Preferred term . | All grades, n (%) . | Grade ≥3, n (%) . |
|---|---|---|
| Cough | 5 (41.7) | 0 |
| Neutropenia | 5 (41.7) | 2 (16.7) |
| Upper respiratory tract infection | 4 (33.3) | 0 |
| Contusion | 3 (25) | 0 |
| Dyspnea | 3 (25) | 1 (8.3) |
| Fatigue | 3 (25) | 0 |
| Peripheral swelling | 3 (25) | 1 (8.3) |
| Petechiae | 3 (25) | 0 |
| Abdominal distension | 2 (16.7) | 0 |
| Arthralgia | 2 (16.7) | 0 |
| Basal cell carcinoma | 2 (16.7) | 0 |
| Chronic obstructive pulmonary disease | 2 (16.7) | 1 (8.3) |
| Electrocardiogram QT prolonged | 2 (16.7) | 1 (8.3) |
| Epistaxis | 2 (16.7) | 0 |
| Gastroesophageal reflux disease | 2 (16.7) | 0 |
| Nausea | 2 (16.7) | 0 |
| Nephrolithiasis | 2 (16.7) | 1 (8.3) |
| Edema peripheral | 2 (16.7) | 0 |
| Oral herpes | 2 (16.7) | 0 |
| Pruritus | 2 (16.7) | 0 |
| Rhinitis allergic | 2 (16.7) | 0 |
| Sinusitis | 2 (16.7) | 0 |
| Squamous cell carcinoma of skin | 2 (16.7) | 0 |
| Thrombocytopenia | 2 (16.7) | 1 (8.3) |
| Urinary tract infection | 2 (16.7) | 1 (8.3) |