AEs within 1 month that were potentially related to CAR T-cell infusion
| AEs . | Any . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|---|
| Any | 28 (100) | 2 (7) | 7 (25) | 10 (36) | 9 (32) |
| CRS | 14 (50) | 8 (29) | 2 (7) | 4 (14) | |
| CRES | 6 (21) | 4 (14) | 2 (7) | ||
| General disorders and administration site conditions | |||||
| Pyrexia | 25 (89) | 10 (36) | 5 (18) | 10 (36) | |
| Fatigue | 27 (96) | 25 (89) | 2 (7) | ||
| Skeletal joint pain | 10 (36) | 10 (36) | |||
| Skin rash | 6 (21) | 6 (21) | |||
| Edema | 8 (29) | 6 (21) | 1 (4) | 1 (4) | |
| Headache | 7 (25) | 7 (25) | |||
| Dizziness | 10 (36) | 10 (36) | |||
| Rigor | 12 (43) | 9 (32) | 3 (11) | ||
| Hyponoia | 3 (11) | 2 (7) | 1 (4) | ||
| Laboratory tests | |||||
| Increased alanine aminotransferase | 10 (36) | 8 (29) | 2 (7) | ||
| Increased aspartate aminotransferase | 13 (47) | 10 (36) | 3 (11) | ||
| Increased γ-glutamy ltransferase | 8 (29) | 3 (11) | 3 (11) | 2 (7) | |
| Increased creatinine | 1 (4) | 1 (4) | |||
| Increased total bilirubin | 3 (11) | 2 (7) | 1 (4) | ||
| Decreased platelet count | 21 (75) | 10 (36) | 4 (14) | 3 (11) | 4 (14) |
| Neutropenia | 22 (79) | 1 (4) | 4 (14) | 9 (32) | 8 (29) |
| Disorders of the blood and lymphatic, respiratory, renal, and GI systems | |||||
| Anemia | 4 (14) | 4 (14) | |||
| Hypotension | 7 (25) | 3 (11) | 2 (7) | 2 (7) | |
| Hypoalbuminemia | 8 (29) | 8 (29) | |||
| Hypokalemia | 4 (14) | 3 (11) | 1 (4) | ||
| Hyponatremia | 11 (39) | 9 (32) | 1 (4) | 1 (4) | |
| Hypocalcemia | 1 (4) | 1 (4) | |||
| Tachycardia | 12 (43) | 8 (29) | 3 (11) | 1 (4) | |
| Dyspnea | 3 (11) | 1 (4) | 1 (4) | 1 (4) | |
| Diarrhea | 7 (25) | 7 (25) | |||
| Neurologic events | |||||
| Anxiety | 3 (11) | 1 (4) | 1 (4) | 1 (4) | |
| Somnolence | 1 (4) | 1 (4) | |||
| Tremor | 5 (18) | 5 (18) | |||
| Disturbance in attention | 3 (11) | 2 (7) | 1 (4) | ||
| Speech disorder | 1 (4) | 1 (4) | |||
| Abnormal thinking | 1 (4) | 1 (4) | |||
| Infections | |||||
| Herpes zoster | 15 (54) | 12 (43) | 2 (7) | 1 (4) | |
| Viral infection | 3 (11) | 2 (7) | 1 (4) | ||
| Bacterial infection | 6 (21) | 5 (18) | 1 (4) |
| AEs . | Any . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|---|
| Any | 28 (100) | 2 (7) | 7 (25) | 10 (36) | 9 (32) |
| CRS | 14 (50) | 8 (29) | 2 (7) | 4 (14) | |
| CRES | 6 (21) | 4 (14) | 2 (7) | ||
| General disorders and administration site conditions | |||||
| Pyrexia | 25 (89) | 10 (36) | 5 (18) | 10 (36) | |
| Fatigue | 27 (96) | 25 (89) | 2 (7) | ||
| Skeletal joint pain | 10 (36) | 10 (36) | |||
| Skin rash | 6 (21) | 6 (21) | |||
| Edema | 8 (29) | 6 (21) | 1 (4) | 1 (4) | |
| Headache | 7 (25) | 7 (25) | |||
| Dizziness | 10 (36) | 10 (36) | |||
| Rigor | 12 (43) | 9 (32) | 3 (11) | ||
| Hyponoia | 3 (11) | 2 (7) | 1 (4) | ||
| Laboratory tests | |||||
| Increased alanine aminotransferase | 10 (36) | 8 (29) | 2 (7) | ||
| Increased aspartate aminotransferase | 13 (47) | 10 (36) | 3 (11) | ||
| Increased γ-glutamy ltransferase | 8 (29) | 3 (11) | 3 (11) | 2 (7) | |
| Increased creatinine | 1 (4) | 1 (4) | |||
| Increased total bilirubin | 3 (11) | 2 (7) | 1 (4) | ||
| Decreased platelet count | 21 (75) | 10 (36) | 4 (14) | 3 (11) | 4 (14) |
| Neutropenia | 22 (79) | 1 (4) | 4 (14) | 9 (32) | 8 (29) |
| Disorders of the blood and lymphatic, respiratory, renal, and GI systems | |||||
| Anemia | 4 (14) | 4 (14) | |||
| Hypotension | 7 (25) | 3 (11) | 2 (7) | 2 (7) | |
| Hypoalbuminemia | 8 (29) | 8 (29) | |||
| Hypokalemia | 4 (14) | 3 (11) | 1 (4) | ||
| Hyponatremia | 11 (39) | 9 (32) | 1 (4) | 1 (4) | |
| Hypocalcemia | 1 (4) | 1 (4) | |||
| Tachycardia | 12 (43) | 8 (29) | 3 (11) | 1 (4) | |
| Dyspnea | 3 (11) | 1 (4) | 1 (4) | 1 (4) | |
| Diarrhea | 7 (25) | 7 (25) | |||
| Neurologic events | |||||
| Anxiety | 3 (11) | 1 (4) | 1 (4) | 1 (4) | |
| Somnolence | 1 (4) | 1 (4) | |||
| Tremor | 5 (18) | 5 (18) | |||
| Disturbance in attention | 3 (11) | 2 (7) | 1 (4) | ||
| Speech disorder | 1 (4) | 1 (4) | |||
| Abnormal thinking | 1 (4) | 1 (4) | |||
| Infections | |||||
| Herpes zoster | 15 (54) | 12 (43) | 2 (7) | 1 (4) | |
| Viral infection | 3 (11) | 2 (7) | 1 (4) | ||
| Bacterial infection | 6 (21) | 5 (18) | 1 (4) |
All data are n (%). Individual symptoms of AEs were graded using CTCAE, version 4.0.
GI, gastrointestinal.