Clonally restricted mutations observed in specific clinical settings in the absence of overt neoplasia
| Clinical setting and reference(s) . | Gene . |
|---|---|
| Aging-associated: ARCH or CHIP2-4,16,17 | DNMT3A, TET2, ASXL1, JAK2, TP53; many others are recurrent but less frequent |
| History of chemotherapy or radiotherapy35,36 | TP53, PPM1D |
| Aplastic anemia34 | BCOR, BCORL1, PIGA; DNMT3A, ASXL1 |
| Severe congenital neutropenia or Shwachman-Bodian-Diamond syndrome73,74 | CSF3R, TP53 |
| Unexplained monocytosis75 | ASXL1, CBL, DNMT3A, NRAS, RUNX1 |
| Clinical setting and reference(s) . | Gene . |
|---|---|
| Aging-associated: ARCH or CHIP2-4,16,17 | DNMT3A, TET2, ASXL1, JAK2, TP53; many others are recurrent but less frequent |
| History of chemotherapy or radiotherapy35,36 | TP53, PPM1D |
| Aplastic anemia34 | BCOR, BCORL1, PIGA; DNMT3A, ASXL1 |
| Severe congenital neutropenia or Shwachman-Bodian-Diamond syndrome73,74 | CSF3R, TP53 |
| Unexplained monocytosis75 | ASXL1, CBL, DNMT3A, NRAS, RUNX1 |