hrombosis in Myeloma IX and XI trials, by site
| Induction treatment received . | Venous thrombosis . | Arterial thrombosis . | Total . | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DVT below knee . | DVT above knee . | PE . | Other VTE . | Superficial thrombophlebitis . | Line-associated VTE . | PE or DVT (type unknown) . | Location of recent operation . | Stroke . | TIA . | Arterial thrombosis . | MI . | |||||||||||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | |
| Myeloma IX | ||||||||||||||||||||||||||
| Transplant-eligible | ||||||||||||||||||||||||||
| CVAD | 23 | 14.5 | 22 | 13.8 | 35 | 22.0 | 9 | 5.7 | 1 | 0.6 | 59 | 37.1 | 10 | 6.3 | NR | 159 | 100 | |||||||||
| CTD | 22 | 20.4 | 26 | 24.1 | 45 | 41.7 | 3 | 2.8 | 1 | 0.9 | 2 | 1.9 | 9 | 8.3 | NR | 108 | 100 | |||||||||
| Total | 45 | 16.9 | 48 | 18.0 | 80 | 30.0 | 12 | 4.5 | 2 | 0.7 | 61 | 22.8 | 19 | 7.1 | NR | 267 | 100 | |||||||||
| Transplant-ineligible | ||||||||||||||||||||||||||
| MP | 2 | 11.1 | 10 | 55.6 | 6 | 33.3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | NR | 18 | 100 | |||||||||
| CTDa | 22 | 26.5 | 15 | 18.1 | 39 | 47.0 | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 | 6 | 7.2 | NR | 83 | 100 | |||||||||
| Total | 24 | 23.8 | 25 | 24.8 | 45 | 44.6 | 1 | 1.0 | 0 | 0.0 | 0 | 0.0 | 6 | 5.9 | NR | 101 | 100 | |||||||||
| Total | 69 | 18.8 | 73 | 19.8 | 125 | 34.0 | 13 | 3.5 | 2 | 0.5 | 61 | 16.6 | 25 | 6.8 | NR | 368 | 100 | |||||||||
| Myeloma XI | ||||||||||||||||||||||||||
| Transplant-eligible | ||||||||||||||||||||||||||
| CTD | 37 | 20.8 | 39 | 21.9 | 78 | 43.8 | 7 | 3.9 | 1 | 0.6 | 1 | 0.6 | NR | 0 | 0.0 | 8 | 4.5 | 3 | 1.7 | 2 | 1.1 | 2 | 1.1 | 178 | 100 | |
| CRD | 49 | 28.2 | 51 | 29.3 | 51 | 29.3 | 9 | 5.2 | 1 | 0.6 | 0 | 0.0 | NR | 1 | 0.6 | 6 | 3.4 | 3 | 1.7 | 1 | 0.6 | 2 | 1.1 | 174 | 100 | |
| KCRD | 37 | 30.1 | 28 | 22.8 | 26 | 21.1 | 18 | 14.6 | 1 | 0.8 | 3 | 2.4 | NR | 1 | 0.8 | 3 | 2.4 | 3 | 2.4 | 1 | 0.8 | 2 | 1.6 | 123 | 100 | |
| Total | 123 | 25.9 | 118 | 24.8 | 155 | 32.6 | 34 | 7.2 | 3 | 0.6 | 4 | 0.8 | NR | 2 | 0.4 | 17 | 3.6 | 9 | 1.9 | 4 | 0.8 | 6 | 1.3 | 475 | 100 | |
| Transplant-ineligible | ||||||||||||||||||||||||||
| CTDa | 25 | 19.7 | 30 | 23.6 | 44 | 34.6 | 11 | 8.7 | 0 | 0.0 | 0 | 0.0 | NR | 1 | 0.8 | 8 | 6.3 | 7 | 5.5 | 0 | 0.0 | 1 | 0.8 | 127 | 100 | |
| CRDa | 29 | 20.1 | 22 | 15.3 | 44 | 30.6 | 20 | 13.9 | 0 | 0.0 | 0 | 0.0 | NR | 0 | 0.0 | 18 | 12.5 | 8 | 5.6 | 1 | 0.7 | 2 | 1.4 | 144 | 100 | |
| Total | 54 | 19.9 | 52 | 19.2 | 88 | 32.5 | 31 | 11.4 | 0 | 0.0 | 0 | 0.0 | NR | 1 | 0.4 | 26 | 9.6 | 15 | 5.5 | 1 | 0.4 | 3 | 1.1 | 271 | 100 | |
| Total | 177 | 23.7 | 170 | 22.8 | 243 | 32.6 | 65 | 8.7 | 3 | 0.4 | 4 | 0.5 | NR | 3 | 0.4 | 43 | 5.8 | 24 | 3.2 | 5 | 0.7 | 9 | 1.2 | 746 | 100 | |
| Induction treatment received . | Venous thrombosis . | Arterial thrombosis . | Total . | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DVT below knee . | DVT above knee . | PE . | Other VTE . | Superficial thrombophlebitis . | Line-associated VTE . | PE or DVT (type unknown) . | Location of recent operation . | Stroke . | TIA . | Arterial thrombosis . | MI . | |||||||||||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | |
| Myeloma IX | ||||||||||||||||||||||||||
| Transplant-eligible | ||||||||||||||||||||||||||
| CVAD | 23 | 14.5 | 22 | 13.8 | 35 | 22.0 | 9 | 5.7 | 1 | 0.6 | 59 | 37.1 | 10 | 6.3 | NR | 159 | 100 | |||||||||
| CTD | 22 | 20.4 | 26 | 24.1 | 45 | 41.7 | 3 | 2.8 | 1 | 0.9 | 2 | 1.9 | 9 | 8.3 | NR | 108 | 100 | |||||||||
| Total | 45 | 16.9 | 48 | 18.0 | 80 | 30.0 | 12 | 4.5 | 2 | 0.7 | 61 | 22.8 | 19 | 7.1 | NR | 267 | 100 | |||||||||
| Transplant-ineligible | ||||||||||||||||||||||||||
| MP | 2 | 11.1 | 10 | 55.6 | 6 | 33.3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | NR | 18 | 100 | |||||||||
| CTDa | 22 | 26.5 | 15 | 18.1 | 39 | 47.0 | 1 | 1.2 | 0 | 0.0 | 0 | 0.0 | 6 | 7.2 | NR | 83 | 100 | |||||||||
| Total | 24 | 23.8 | 25 | 24.8 | 45 | 44.6 | 1 | 1.0 | 0 | 0.0 | 0 | 0.0 | 6 | 5.9 | NR | 101 | 100 | |||||||||
| Total | 69 | 18.8 | 73 | 19.8 | 125 | 34.0 | 13 | 3.5 | 2 | 0.5 | 61 | 16.6 | 25 | 6.8 | NR | 368 | 100 | |||||||||
| Myeloma XI | ||||||||||||||||||||||||||
| Transplant-eligible | ||||||||||||||||||||||||||
| CTD | 37 | 20.8 | 39 | 21.9 | 78 | 43.8 | 7 | 3.9 | 1 | 0.6 | 1 | 0.6 | NR | 0 | 0.0 | 8 | 4.5 | 3 | 1.7 | 2 | 1.1 | 2 | 1.1 | 178 | 100 | |
| CRD | 49 | 28.2 | 51 | 29.3 | 51 | 29.3 | 9 | 5.2 | 1 | 0.6 | 0 | 0.0 | NR | 1 | 0.6 | 6 | 3.4 | 3 | 1.7 | 1 | 0.6 | 2 | 1.1 | 174 | 100 | |
| KCRD | 37 | 30.1 | 28 | 22.8 | 26 | 21.1 | 18 | 14.6 | 1 | 0.8 | 3 | 2.4 | NR | 1 | 0.8 | 3 | 2.4 | 3 | 2.4 | 1 | 0.8 | 2 | 1.6 | 123 | 100 | |
| Total | 123 | 25.9 | 118 | 24.8 | 155 | 32.6 | 34 | 7.2 | 3 | 0.6 | 4 | 0.8 | NR | 2 | 0.4 | 17 | 3.6 | 9 | 1.9 | 4 | 0.8 | 6 | 1.3 | 475 | 100 | |
| Transplant-ineligible | ||||||||||||||||||||||||||
| CTDa | 25 | 19.7 | 30 | 23.6 | 44 | 34.6 | 11 | 8.7 | 0 | 0.0 | 0 | 0.0 | NR | 1 | 0.8 | 8 | 6.3 | 7 | 5.5 | 0 | 0.0 | 1 | 0.8 | 127 | 100 | |
| CRDa | 29 | 20.1 | 22 | 15.3 | 44 | 30.6 | 20 | 13.9 | 0 | 0.0 | 0 | 0.0 | NR | 0 | 0.0 | 18 | 12.5 | 8 | 5.6 | 1 | 0.7 | 2 | 1.4 | 144 | 100 | |
| Total | 54 | 19.9 | 52 | 19.2 | 88 | 32.5 | 31 | 11.4 | 0 | 0.0 | 0 | 0.0 | NR | 1 | 0.4 | 26 | 9.6 | 15 | 5.5 | 1 | 0.4 | 3 | 1.1 | 271 | 100 | |
| Total | 177 | 23.7 | 170 | 22.8 | 243 | 32.6 | 65 | 8.7 | 3 | 0.4 | 4 | 0.5 | NR | 3 | 0.4 | 43 | 5.8 | 24 | 3.2 | 5 | 0.7 | 9 | 1.2 | 746 | 100 | |
MI, myocardial infarction; NR, not recorded; PE, pulmonary embolism; TIA, transient ischemic attack.