Baseline characteristics for patients in Myeloma IX and Myeloma XI trials by VTE occurrence
| Characteristic . | Myeloma IX . | Myeloma XI . | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thrombosis (n = 295) . | No thrombosis (n = 1641) . | Total (N = 1936) . | P . | Thrombosis (n = 599) . | No Thrombosis (n = 3759) . | Total (N = 4358) . | P . | |||||||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | |||||||
| Sex | .0063 | .0458 | ||||||||||||||||
| Male | 154 | 52.2 | 996 | 60.7 | 1150 | 59.4 | 373 | 62.3 | 2178 | 57.9 | 2551 | 58.5 | ||||||
| Female | 141 | 47.8 | 645 | 39.3 | 786 | 40.6 | 226 | 37.7 | 1581 | 42.1 | 1807 | 41.5 | ||||||
| Age | <.0001 | .5952 | ||||||||||||||||
| Mean (SD) | 61.8 (10.07) | 65.0 (10.17) | 64.5 (10.22) | 65.5 (9.67) | 65.7 (10.33) | 65.7 (10.24) | ||||||||||||
| Median (range) | 62.0 (31.0-87.0) | 66.0 (31.0-89.0) | 65.0 (31.0-89.0) | 67.0 (37.0-89.0) | 67.0 (28.0-92.0) | 67.0 (28.0-92.0) | ||||||||||||
| Ethnicity | .4425 | .2801 | ||||||||||||||||
| White | 292 | 99.0 | 1586 | 96.6 | 1878 | 97.0 | 576 | 96.2 | 3498 | 93.1 | 4074 | 93.5 | ||||||
| Black (black Caribbean, black African, other) | 1 | 0.3 | 26 | 1.6 | 27 | 1.4 | 6 | 1.0 | 69 | 1.8 | 75 | 1.7 | ||||||
| Asian (Indian, Pakistani, Bangladeshi, other) | 1 | 0.3 | 14 | 0.9 | 15 | 0.8 | 5 | 0.8 | 87 | 2.3 | 92 | 2.1 | ||||||
| Other | 1 | 0.3 | 15 | 0.9 | 16 | 0.8 | 4 | 0.7 | 35 | .9 | 39 | .9 | ||||||
| Unknown | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 8 | 1.3 | 70 | 1.7 | 78 | 1.8 | ||||||
| WHO performance status | .4739 | .1610 | ||||||||||||||||
| 0 | 79 | 26.8 | 386 | 23.5 | 465 | 24.0 | 187 | 31.2 | 1359 | 36.2 | 1546 | 35.5 | ||||||
| 1 | 134 | 45.4 | 737 | 44.9 | 871 | 45.0 | 248 | 41.4 | 1471 | 39.1 | 1719 | 39.4 | ||||||
| 2 | 51 | 17.3 | 313 | 19.1 | 364 | 18.8 | 102 | 17.0 | 543 | 14.4 | 645 | 14.8 | ||||||
| 3 | 29 | 9.8 | 169 | 10.3 | 198 | 10.2 | 28 | 4.7 | 178 | 4.7 | 206 | 4.7 | ||||||
| 4 | 1 | 0.3 | 21 | 1.3 | 22 | 1.1 | 3 | 0.5 | 19 | 0.5 | 22 | 0.5 | ||||||
| Missing | 1 | 0.3 | 15 | 0.9 | 16 | 0.8 | 31 | 5.2 | 189 | 5.0 | 220 | 5.0 | ||||||
| β2 microglobulin, mg/L | .3240 | .0167 | ||||||||||||||||
| Mean (SD) | 5.7 (5.10) | 6.1 (6.02) | 6.0 (5.89) | 4.8 (3.48) | 5.3 (4.37) | 5.2 (4.26) | ||||||||||||
| Median (range) | 4.1 (0.2-58.0) | 4.4 (0.1-114.1) | 4.4 (0.1-114.1) | 3.7 (0.9-33.9) | 4.0 (0.0-88.0) | 4.0 (0.0-88.0) | ||||||||||||
| Missing | 27 | 135 | 162 | 221 | 1350 | 1571 | ||||||||||||
| Creatinine, µmol/L | .2553 | .8659 | ||||||||||||||||
| Mean (SD) | 117.6 (68.15) | 118.0 (61.70) | 118.0 (62.70) | 98.6 (46.57) | 101.1 (55.04) | 10.7 (53.95) | ||||||||||||
| Median (Range) | 97.0 (49.0-495.0) | 100.0 (2.4-468.0) | 100.0 (2.4-495.0) | 86.0 (32.0-390.0) | 86.0 (32.0-609.0) | 86.0 (32.0-609.0) | ||||||||||||
| Missing | 12 | 55 | 67 | 0 | 1 | 1 | ||||||||||||
| Calcium, µmol/L | .3303 | .0826 | ||||||||||||||||
| Mean (SD) | 2.4 (0.26) | 2.4 (0.70) | 2.4 (0.65) | 2.4 (0.21) | 2.4 (0.25) | 2.4 (0.25) | ||||||||||||
| Median (range) | 2.4 (1.6-3.5) | 2.4 (1.3-26.4) | 2.4 (1.3-26.4) | 2.4 (1.6-3.6) | 2.4 (1.3-4.9) | 2.4 (1.3-4.9) | ||||||||||||
| Missing | 11 | 65 | 76 | 0 | 3 | 3 | ||||||||||||
| Platelets ×109/L | .2924 | .6221 | ||||||||||||||||
| Mean (SD) | 254.0 (94.80) | 247.5 (97.60) | 248.5 (97.18) | 244.0 (95.22) | 245.8 (96.87) | 245.6 (96.64) | ||||||||||||
| Median (range) | 241.0 (43.0-642.0) | 235.0 (15.0-825.0) | 237.0 (15.0-825.0) | 234.0 (3.0-1112.0) | 235.0 (2.0-1093.0) | 234.0 (2.0-1112.0) | ||||||||||||
| Missing | 0 | 1 | 1 | 0 | 0 | 0 | ||||||||||||
| Hemoglobin g/dL | .5868 | .0001 | ||||||||||||||||
| Mean (SD) | 10.7 (1.86) | 10.8 (3.43) | 10.8 (3.24) | 11.1 (1.94) | 10.7 (1.88) | 10.8 (1.89) | ||||||||||||
| Median (range) | 10.7 (6.5-17.8) | 10.5 (4.0-95.0) | 10.6 (4.0-95.0) | 10.9 (5.2-16.8) | 10.7 (3.3-17.4) | 1.7 (3.3-17.4) | ||||||||||||
| Missing | 0 | 1 | 1 | 1 | 1 | 2 | ||||||||||||
| Paraprotein type | .0430 | .1563 | ||||||||||||||||
| IgG | 193 | 65.4 | 962 | 58.6 | 1155 | 59.7 | 372 | 62.1 | 2296 | 61.1 | 2668 | 61.2 | ||||||
| IgA | 59 | 20.0 | 378 | 23.0 | 437 | 22.6 | 138 | 23.0 | 938 | 25.0 | 1076 | 24.7 | ||||||
| IgM | 0 | 0.0 | 8 | 0.5 | 8 | 0.4 | 1 | 0.2 | 15 | 0.4 | 16 | 0.4 | ||||||
| IgD | 9 | 3.1 | 27 | 1.6 | 36 | 1.9 | 1 | 0.2 | 34 | 0.9 | 35 | 0.8 | ||||||
| Non-secretor | 6 | 2.0 | 26 | 1.6 | 32 | 1.7 | 6 | 1 | 20 | 0.5 | 26 | 0.6 | ||||||
| Light chain only | 26 | 8.8 | 220 | 13.4 | 246 | 12.7 | 81 | 13.5 | 451 | 12.0 | 532 | 12.2 | ||||||
| Missing | 2 | 0.7 | 20 | 1.2 | 22 | 1.1 | 0 | 0.0 | 5 | 0.1 | 5 | 0.1 | ||||||
| Light chain type | .4451 | .0741 | ||||||||||||||||
| Λ | 101 | 34.2 | 519 | 31.6 | 620 | 32.0 | 179 | 29.9 | 1269 | 33.8 | 1448 | 33.2 | ||||||
| κ | 172 | 58.3 | 981 | 59.8 | 1153 | 59.6 | 411 | 68.6 | 2455 | 65.3 | 2866 | 65.8 | ||||||
| Missing | 22 | 7.5 | 141 | 8.6 | 163 | 8.4 | 9 | 1.5 | 35 | 0.9 | 44 | 1.0 | ||||||
| Characteristic . | Myeloma IX . | Myeloma XI . | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thrombosis (n = 295) . | No thrombosis (n = 1641) . | Total (N = 1936) . | P . | Thrombosis (n = 599) . | No Thrombosis (n = 3759) . | Total (N = 4358) . | P . | |||||||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | No. . | % . | |||||||
| Sex | .0063 | .0458 | ||||||||||||||||
| Male | 154 | 52.2 | 996 | 60.7 | 1150 | 59.4 | 373 | 62.3 | 2178 | 57.9 | 2551 | 58.5 | ||||||
| Female | 141 | 47.8 | 645 | 39.3 | 786 | 40.6 | 226 | 37.7 | 1581 | 42.1 | 1807 | 41.5 | ||||||
| Age | <.0001 | .5952 | ||||||||||||||||
| Mean (SD) | 61.8 (10.07) | 65.0 (10.17) | 64.5 (10.22) | 65.5 (9.67) | 65.7 (10.33) | 65.7 (10.24) | ||||||||||||
| Median (range) | 62.0 (31.0-87.0) | 66.0 (31.0-89.0) | 65.0 (31.0-89.0) | 67.0 (37.0-89.0) | 67.0 (28.0-92.0) | 67.0 (28.0-92.0) | ||||||||||||
| Ethnicity | .4425 | .2801 | ||||||||||||||||
| White | 292 | 99.0 | 1586 | 96.6 | 1878 | 97.0 | 576 | 96.2 | 3498 | 93.1 | 4074 | 93.5 | ||||||
| Black (black Caribbean, black African, other) | 1 | 0.3 | 26 | 1.6 | 27 | 1.4 | 6 | 1.0 | 69 | 1.8 | 75 | 1.7 | ||||||
| Asian (Indian, Pakistani, Bangladeshi, other) | 1 | 0.3 | 14 | 0.9 | 15 | 0.8 | 5 | 0.8 | 87 | 2.3 | 92 | 2.1 | ||||||
| Other | 1 | 0.3 | 15 | 0.9 | 16 | 0.8 | 4 | 0.7 | 35 | .9 | 39 | .9 | ||||||
| Unknown | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 8 | 1.3 | 70 | 1.7 | 78 | 1.8 | ||||||
| WHO performance status | .4739 | .1610 | ||||||||||||||||
| 0 | 79 | 26.8 | 386 | 23.5 | 465 | 24.0 | 187 | 31.2 | 1359 | 36.2 | 1546 | 35.5 | ||||||
| 1 | 134 | 45.4 | 737 | 44.9 | 871 | 45.0 | 248 | 41.4 | 1471 | 39.1 | 1719 | 39.4 | ||||||
| 2 | 51 | 17.3 | 313 | 19.1 | 364 | 18.8 | 102 | 17.0 | 543 | 14.4 | 645 | 14.8 | ||||||
| 3 | 29 | 9.8 | 169 | 10.3 | 198 | 10.2 | 28 | 4.7 | 178 | 4.7 | 206 | 4.7 | ||||||
| 4 | 1 | 0.3 | 21 | 1.3 | 22 | 1.1 | 3 | 0.5 | 19 | 0.5 | 22 | 0.5 | ||||||
| Missing | 1 | 0.3 | 15 | 0.9 | 16 | 0.8 | 31 | 5.2 | 189 | 5.0 | 220 | 5.0 | ||||||
| β2 microglobulin, mg/L | .3240 | .0167 | ||||||||||||||||
| Mean (SD) | 5.7 (5.10) | 6.1 (6.02) | 6.0 (5.89) | 4.8 (3.48) | 5.3 (4.37) | 5.2 (4.26) | ||||||||||||
| Median (range) | 4.1 (0.2-58.0) | 4.4 (0.1-114.1) | 4.4 (0.1-114.1) | 3.7 (0.9-33.9) | 4.0 (0.0-88.0) | 4.0 (0.0-88.0) | ||||||||||||
| Missing | 27 | 135 | 162 | 221 | 1350 | 1571 | ||||||||||||
| Creatinine, µmol/L | .2553 | .8659 | ||||||||||||||||
| Mean (SD) | 117.6 (68.15) | 118.0 (61.70) | 118.0 (62.70) | 98.6 (46.57) | 101.1 (55.04) | 10.7 (53.95) | ||||||||||||
| Median (Range) | 97.0 (49.0-495.0) | 100.0 (2.4-468.0) | 100.0 (2.4-495.0) | 86.0 (32.0-390.0) | 86.0 (32.0-609.0) | 86.0 (32.0-609.0) | ||||||||||||
| Missing | 12 | 55 | 67 | 0 | 1 | 1 | ||||||||||||
| Calcium, µmol/L | .3303 | .0826 | ||||||||||||||||
| Mean (SD) | 2.4 (0.26) | 2.4 (0.70) | 2.4 (0.65) | 2.4 (0.21) | 2.4 (0.25) | 2.4 (0.25) | ||||||||||||
| Median (range) | 2.4 (1.6-3.5) | 2.4 (1.3-26.4) | 2.4 (1.3-26.4) | 2.4 (1.6-3.6) | 2.4 (1.3-4.9) | 2.4 (1.3-4.9) | ||||||||||||
| Missing | 11 | 65 | 76 | 0 | 3 | 3 | ||||||||||||
| Platelets ×109/L | .2924 | .6221 | ||||||||||||||||
| Mean (SD) | 254.0 (94.80) | 247.5 (97.60) | 248.5 (97.18) | 244.0 (95.22) | 245.8 (96.87) | 245.6 (96.64) | ||||||||||||
| Median (range) | 241.0 (43.0-642.0) | 235.0 (15.0-825.0) | 237.0 (15.0-825.0) | 234.0 (3.0-1112.0) | 235.0 (2.0-1093.0) | 234.0 (2.0-1112.0) | ||||||||||||
| Missing | 0 | 1 | 1 | 0 | 0 | 0 | ||||||||||||
| Hemoglobin g/dL | .5868 | .0001 | ||||||||||||||||
| Mean (SD) | 10.7 (1.86) | 10.8 (3.43) | 10.8 (3.24) | 11.1 (1.94) | 10.7 (1.88) | 10.8 (1.89) | ||||||||||||
| Median (range) | 10.7 (6.5-17.8) | 10.5 (4.0-95.0) | 10.6 (4.0-95.0) | 10.9 (5.2-16.8) | 10.7 (3.3-17.4) | 1.7 (3.3-17.4) | ||||||||||||
| Missing | 0 | 1 | 1 | 1 | 1 | 2 | ||||||||||||
| Paraprotein type | .0430 | .1563 | ||||||||||||||||
| IgG | 193 | 65.4 | 962 | 58.6 | 1155 | 59.7 | 372 | 62.1 | 2296 | 61.1 | 2668 | 61.2 | ||||||
| IgA | 59 | 20.0 | 378 | 23.0 | 437 | 22.6 | 138 | 23.0 | 938 | 25.0 | 1076 | 24.7 | ||||||
| IgM | 0 | 0.0 | 8 | 0.5 | 8 | 0.4 | 1 | 0.2 | 15 | 0.4 | 16 | 0.4 | ||||||
| IgD | 9 | 3.1 | 27 | 1.6 | 36 | 1.9 | 1 | 0.2 | 34 | 0.9 | 35 | 0.8 | ||||||
| Non-secretor | 6 | 2.0 | 26 | 1.6 | 32 | 1.7 | 6 | 1 | 20 | 0.5 | 26 | 0.6 | ||||||
| Light chain only | 26 | 8.8 | 220 | 13.4 | 246 | 12.7 | 81 | 13.5 | 451 | 12.0 | 532 | 12.2 | ||||||
| Missing | 2 | 0.7 | 20 | 1.2 | 22 | 1.1 | 0 | 0.0 | 5 | 0.1 | 5 | 0.1 | ||||||
| Light chain type | .4451 | .0741 | ||||||||||||||||
| Λ | 101 | 34.2 | 519 | 31.6 | 620 | 32.0 | 179 | 29.9 | 1269 | 33.8 | 1448 | 33.2 | ||||||
| κ | 172 | 58.3 | 981 | 59.8 | 1153 | 59.6 | 411 | 68.6 | 2455 | 65.3 | 2866 | 65.8 | ||||||
| Missing | 22 | 7.5 | 141 | 8.6 | 163 | 8.4 | 9 | 1.5 | 35 | 0.9 | 44 | 1.0 | ||||||
All values are number of patients and percent, unless otherwise indicated.
IgG, immunoglobulin G; SD, standard deviation, WHO, World Health Organization.