Clinical features of primary HHV8-negative EBL and PEL
| Clinical characteristics . | Primary HHV8-negative EBL . | PEL . |
|---|---|---|
| Total, n | 64 | 5 |
| Age, y | ||
| Median | 77 | 77 |
| Range | 57-98 | 38-99 |
| Sex, male/female, n | 40/24 | 4/1 |
| ECOG performance status score 0-1 | 33/62 (53) | 4/5 (80) |
| B symptoms | 8/61 (13) | 2/4 (50) |
| Fever | 4/61 (7) | 1/4 (25) |
| Night sweats | 2/61 (3) | 0/4 (0) |
| Weight loss | 2/61 (3) | 1/4 (25) |
| Dyspnea | 46/64 (72) | 4/5 (80) |
| Cough | 11/64 (17) | 0/5 (0) |
| Abdominal distention | 3/64 (5) | 1/5 (20) |
| Pedal edema | 17/64 (27) | 1/5 (20) |
| IPI score 3-5 | 48/61 (79) | 3/5 (60) |
| Hemoglobin level ≤10 g/dL | 11/64 (17) | 2/5 (40) |
| Elevated serum lactate dehydrogenase level | 42/63 (67) | 3/5 (60) |
| Serum creatinine level ≥1.5 mg/dL | 11/62 (18) | 1/5 (20) |
| Serum C-reactive protein level >5.0 mg/dL | 11/61 (18) | 1/5 (20) |
| Serum sIL2-R level >5000 U/L | 4/56 (7) | 0/5 (0) |
| HIV antibody positive | 0/58 (0) | 2/4 (50) |
| HBs antigen positive | 0/62 (0) | 0/5 (0) |
| HCV antibody positive | 1/61 (2) | 1/5 (17) |
| History of body cavity fluids | 12/60 (20) | 1/5 (17) |
| Underlying medical condition leading to fluid retention | 30/64 (47) | 2/5 (40) |
| Cirrhosis | 2/64 (3) | 0/5 (0) |
| Myocardial infarction/angina pectoris | 7/64 (10) | 1/5 (20) |
| Arrhythmia | 17/64 (27) | 1/5 (20) |
| Renal dysfunction | 7/64 (11) | 1/5 (20) |
| Hypothyroidism | 5/64 (8) | 0/5 (0) |
| Clinical characteristics . | Primary HHV8-negative EBL . | PEL . |
|---|---|---|
| Total, n | 64 | 5 |
| Age, y | ||
| Median | 77 | 77 |
| Range | 57-98 | 38-99 |
| Sex, male/female, n | 40/24 | 4/1 |
| ECOG performance status score 0-1 | 33/62 (53) | 4/5 (80) |
| B symptoms | 8/61 (13) | 2/4 (50) |
| Fever | 4/61 (7) | 1/4 (25) |
| Night sweats | 2/61 (3) | 0/4 (0) |
| Weight loss | 2/61 (3) | 1/4 (25) |
| Dyspnea | 46/64 (72) | 4/5 (80) |
| Cough | 11/64 (17) | 0/5 (0) |
| Abdominal distention | 3/64 (5) | 1/5 (20) |
| Pedal edema | 17/64 (27) | 1/5 (20) |
| IPI score 3-5 | 48/61 (79) | 3/5 (60) |
| Hemoglobin level ≤10 g/dL | 11/64 (17) | 2/5 (40) |
| Elevated serum lactate dehydrogenase level | 42/63 (67) | 3/5 (60) |
| Serum creatinine level ≥1.5 mg/dL | 11/62 (18) | 1/5 (20) |
| Serum C-reactive protein level >5.0 mg/dL | 11/61 (18) | 1/5 (20) |
| Serum sIL2-R level >5000 U/L | 4/56 (7) | 0/5 (0) |
| HIV antibody positive | 0/58 (0) | 2/4 (50) |
| HBs antigen positive | 0/62 (0) | 0/5 (0) |
| HCV antibody positive | 1/61 (2) | 1/5 (17) |
| History of body cavity fluids | 12/60 (20) | 1/5 (17) |
| Underlying medical condition leading to fluid retention | 30/64 (47) | 2/5 (40) |
| Cirrhosis | 2/64 (3) | 0/5 (0) |
| Myocardial infarction/angina pectoris | 7/64 (10) | 1/5 (20) |
| Arrhythmia | 17/64 (27) | 1/5 (20) |
| Renal dysfunction | 7/64 (11) | 1/5 (20) |
| Hypothyroidism | 5/64 (8) | 0/5 (0) |
Unless otherwise indicated, data are n/N (%).
ECOG, Eastern Cooperative Oncology Group; HBs, hepatitis B virus surface; IPI, International Prognostic Index; sIL2-R, soluble interleukin 2 receptor.