Clinical characteristics of 17 women with BIA-ALCL after breast reconstruction for breast cancer and/or bilateral or contralateral prophylactic mastectomy because of breast cancer risk
| Case . | BRCA mutation information . | Age at breast cancer, y . | Reason for breast implant insertion . | Age at breast implant insertion, y . | Breast implant type and location . | Other breast cancer treatment . | Interval to BIA-ALCL . | BIA-ALCL lymphoma sites . |
|---|---|---|---|---|---|---|---|---|
| 1 | BRCA 1 mutation, details not disclosed | NA | Bilateral prophylactic mastectomy | 46 | Bilateral, Allergan, macrotextured, silicone | NA | 10 | Left breast |
| 2 | BRCA1 gene 5396 + 1G ->A | NA | Bilateral prophylactic mastectomy | 44 | Bilateral, Allergan, macrotextured, silicone | NA | 12 | Right breast |
| 3 | BRCA2 gene 8295T ->A (cys2689end, exon18 | 35 | Right-sided mastectomy for breast cancer; 6 years later left-sided prophylactic mastectomy | 35 and 40 | Bilateral, McGhan, macrotextured, silicone | Chemotherapy and radiotherapy | 8 | Left breast |
| 4 | BRCA1 exon 11C.4097-1G>A splicing (49%) at Alamut/NCBI (confirmed mutation in MLPA/NGS analysis in this study) | 60 | Left-sided mastectomy for breast cancer and right-sided prophylactic mastectomy | 60 | Bilateral, Allergan, macrotextured, silicone | None | 4 and 6 | Left breast |
| 5 | Heterozygous c.5722_5723delCT p.(Leu1908Argfs*2) exon 11 v BRCA2 | 37 | Right-sided mastectomy for breast cancer and left-sided prophylactic mastectomy | 47 | Bilateral, Allergan, macrotextured, silicone | Radiotherapy | 13 | Left breast, axillary lymph node |
| 6 | c.66dupA p.Glu23fs BRCA1, exon 2 | 40 | Right-sided mastectomy for breast cancer and left-sided prophylactic mastectomy | 40 | Bilateral, Allergan, macrotextured, silicone | Chemotherapy | 9 | Left breast |
| 7 | NA | 26 | Right-sided mastectomy for breast cancer (reconstruction 3 y later) | 29 | Right, McGhan, macrotextured, silicone | Chemotherapy and radiotherapy | 26 | Right breast and axilla, right lung |
| 8 | NA | 49 | Right-sided mastectomy for breast cancer and left-sided prophylactic mastectomy (familial cancer, no proven mutation) | 49 | Bilateral, McGhan, macrotextured, silicone | None | 7 | Right breast |
| 9 | NA | 56 | Right-sided mastectomy for breast cancer, left-sided prophylactic mastectomy (familial cancer, no proven mutation) | 56 | Bilateral, McGhan, macrotextured, silicone | Chemotherapy | 5 | Left breast |
| 10 | NA | 51 | Right-sided mastectomy for breast cancer, 6 y later left-sided mastectomy for breast cancer | 51 | Bilateral, Allergan, macrotextured, silicone | None | 6 | Right breast |
| 11 | NA | 46 | Left-sided mastectomy for breast cancer | 46 | Left, Inamed, macrotextured, silicone | None | 13 | Left breast |
| 12 | NA | 48 | Right-sided breast cancer, 1 y later left-sided prophylactic mastectomy left with subsequent reconstruction | 49 | Bilateral, Allergan, macrotextured, silicone | Chemotherapy and hormonal therapy | 9 | Left breast |
| 13 | NA | 51 | Left-sided mastectomy for breast cancer, reconstruction 2 y later | 53 | Left, McGhan, macrotextured, silicone | Chemotherapy and hormonal therapy | 7 | Left breast |
| 14 | NA | 51 | Left-sided mastectomy for breast cancer, reconstruction in 2009 | 53 | Left, Allergan, macrotextured, silicone, | None | 8 | Left breast |
| 15 | NA | 52 | Left-sided mastectomy for mammary carcinoma of the breast, right-sided mastectomy for pain/mastopathy | 52 | Bilateral, McGhan, macrotextured, silicone | None | 12 | Left breast |
| 16 | NA | 59 | Right-sided mastectomy for breast cancer | 61 | Right, McGhan, macrotextured, silicone | Hormonal therapy | 12 | Right breast |
| 17 | NA | 57 | Right-sided mastectomy for breast cancer, contralateral side augmentation | 61 | Bilateral McGhan, macrotextured, silicone | Hormonal therapy | 14 | Right breast |
| Case . | BRCA mutation information . | Age at breast cancer, y . | Reason for breast implant insertion . | Age at breast implant insertion, y . | Breast implant type and location . | Other breast cancer treatment . | Interval to BIA-ALCL . | BIA-ALCL lymphoma sites . |
|---|---|---|---|---|---|---|---|---|
| 1 | BRCA 1 mutation, details not disclosed | NA | Bilateral prophylactic mastectomy | 46 | Bilateral, Allergan, macrotextured, silicone | NA | 10 | Left breast |
| 2 | BRCA1 gene 5396 + 1G ->A | NA | Bilateral prophylactic mastectomy | 44 | Bilateral, Allergan, macrotextured, silicone | NA | 12 | Right breast |
| 3 | BRCA2 gene 8295T ->A (cys2689end, exon18 | 35 | Right-sided mastectomy for breast cancer; 6 years later left-sided prophylactic mastectomy | 35 and 40 | Bilateral, McGhan, macrotextured, silicone | Chemotherapy and radiotherapy | 8 | Left breast |
| 4 | BRCA1 exon 11C.4097-1G>A splicing (49%) at Alamut/NCBI (confirmed mutation in MLPA/NGS analysis in this study) | 60 | Left-sided mastectomy for breast cancer and right-sided prophylactic mastectomy | 60 | Bilateral, Allergan, macrotextured, silicone | None | 4 and 6 | Left breast |
| 5 | Heterozygous c.5722_5723delCT p.(Leu1908Argfs*2) exon 11 v BRCA2 | 37 | Right-sided mastectomy for breast cancer and left-sided prophylactic mastectomy | 47 | Bilateral, Allergan, macrotextured, silicone | Radiotherapy | 13 | Left breast, axillary lymph node |
| 6 | c.66dupA p.Glu23fs BRCA1, exon 2 | 40 | Right-sided mastectomy for breast cancer and left-sided prophylactic mastectomy | 40 | Bilateral, Allergan, macrotextured, silicone | Chemotherapy | 9 | Left breast |
| 7 | NA | 26 | Right-sided mastectomy for breast cancer (reconstruction 3 y later) | 29 | Right, McGhan, macrotextured, silicone | Chemotherapy and radiotherapy | 26 | Right breast and axilla, right lung |
| 8 | NA | 49 | Right-sided mastectomy for breast cancer and left-sided prophylactic mastectomy (familial cancer, no proven mutation) | 49 | Bilateral, McGhan, macrotextured, silicone | None | 7 | Right breast |
| 9 | NA | 56 | Right-sided mastectomy for breast cancer, left-sided prophylactic mastectomy (familial cancer, no proven mutation) | 56 | Bilateral, McGhan, macrotextured, silicone | Chemotherapy | 5 | Left breast |
| 10 | NA | 51 | Right-sided mastectomy for breast cancer, 6 y later left-sided mastectomy for breast cancer | 51 | Bilateral, Allergan, macrotextured, silicone | None | 6 | Right breast |
| 11 | NA | 46 | Left-sided mastectomy for breast cancer | 46 | Left, Inamed, macrotextured, silicone | None | 13 | Left breast |
| 12 | NA | 48 | Right-sided breast cancer, 1 y later left-sided prophylactic mastectomy left with subsequent reconstruction | 49 | Bilateral, Allergan, macrotextured, silicone | Chemotherapy and hormonal therapy | 9 | Left breast |
| 13 | NA | 51 | Left-sided mastectomy for breast cancer, reconstruction 2 y later | 53 | Left, McGhan, macrotextured, silicone | Chemotherapy and hormonal therapy | 7 | Left breast |
| 14 | NA | 51 | Left-sided mastectomy for breast cancer, reconstruction in 2009 | 53 | Left, Allergan, macrotextured, silicone, | None | 8 | Left breast |
| 15 | NA | 52 | Left-sided mastectomy for mammary carcinoma of the breast, right-sided mastectomy for pain/mastopathy | 52 | Bilateral, McGhan, macrotextured, silicone | None | 12 | Left breast |
| 16 | NA | 59 | Right-sided mastectomy for breast cancer | 61 | Right, McGhan, macrotextured, silicone | Hormonal therapy | 12 | Right breast |
| 17 | NA | 57 | Right-sided mastectomy for breast cancer, contralateral side augmentation | 61 | Bilateral McGhan, macrotextured, silicone | Hormonal therapy | 14 | Right breast |
Implant type in the remaining 32 BIA-ALCL cases who received breast implants for cosmetics purposes was Allergan/Inamed/McGhan (n = 15), Eurosilicone (n = 3), Rofill PIP (n = 1), Monobloc (n = 1), Sebbin (n = 1), Mentor (n = 1), Nagor (n = 1), and unknown (n = 9). Other detailed information on these cases can be found in the supplements of de Boer et al.2