Multivariate analysis
| . | OS . | EFS . | GF . | grade 3-4 aGVHD . | cGVHD . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age (in 10 y) | 1.69 (1.30-2.20) | .0001 | 1.11 (0.87-1.40) | .37 | 0.72 (0.49-1.05) | .09 | 1.25 (0.87-1.80) | .22 | 1.35 (1.05-1.75) | .01 |
| Colitis | ||||||||||
| Absent | 1 | 1 | 1 | 1 | 1 | |||||
| Present | 1.72 (0.99-2.99) | .052 | 1.03 (0.65-1.63) | .87 | 0.50 (0.23-1.08) | .08 | 1.38 (0.66-2.84) | .38 | 1.24 (0.70-2.21) | .45 |
| Conditioning regimen | ||||||||||
| Bu/Flu | 1 | 1 | 1 | 1 | 1 | |||||
| Bu/Cy | 1.22 (0.62-2.39) | .54 | 0.81 (0.46-1.42) | .48 | 0.31 (0.11-0.91) | .03 | 2.13 (1.03-4.39) | .04 | 0.81 (0.43-1.52) | .52 |
| Treo/Flu | 0.83 (0.40-1.71) | .62 | 1.11 (0.68-1.81) | .67 | 1.38 (0.7459-2.56) | .30 | 1.82 (0.85-3.89) | .12 | 0.73 (0.36-1.45) | .37 |
| Treo/Flu/TT | 0.32 (0.07-1.34) | .11 | 0.62 (0.28-1.36) | .23 | 0.78 (0.30-2.03) | .62 | 1.56 (0.58-4.16) | .37 | 0.35 (0.11-1.15) | .08 |
| Other | 1.04 (0.48-2.27) | .90 | 1.62 (0.93-2.80) | .08 | 2.00 (1.001-4.01) | .04 | 1.2759 (0.43-3.77) | .65 | 1.33 (0.63-2.79) | .44 |
| Donor type | ||||||||||
| MFD | 1 | 1 | 1 | 1 | 1 | |||||
| MUD | 1.27 (0.71-2.25) | .40 | 1.89 (1.19-2.98) | .006 | 2.33 (1.19-4.57) | .01 | 1.07 (0.57-2.00) | .82 | 1.02 (0.62-1.69) | .91 |
| 1-Ag mismatch | 2.29 (1.18-4.42) | .01 | 2.37 (1.38-4.08) | .001 | 2.67 (1.22-5.87) | .01 | 1.67 (0.77-3.61) | .1 | 1.82 (0.98-3.38) | .057 |
| >1-Ag mismatch | 2.46 (0.78-7.72) | .12 | 3.69 (1.65-8.22) | .001 | 5.54 (1.92-15.99) | .001 | 0.57 (0.07-4.52) | .59 | 1.94 (0.63-5.95) | .24 |
| Stem cell source | ||||||||||
| BM | 1 | 1 | 1 | 1 | 1 | |||||
| CB | 1.05 (0.36-3.06) | .92 | 1.22 (0.57-2.61) | .60 | 1.27 (0.48-3.33) | .62 | 1.97 (0.66-5.86) | .22 | 0.61 (0.18-2.03) | .42 |
| PB | 1.02 (0.59-1.76) | .92 | 1.14 (0.76-1.71) | .51 | 1.08 (0.62-1.88) | .77 | 0.75 (0.37-1.51) | .42 | 0.82 (0.48-1.42) | .49 |
| . | OS . | EFS . | GF . | grade 3-4 aGVHD . | cGVHD . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age (in 10 y) | 1.69 (1.30-2.20) | .0001 | 1.11 (0.87-1.40) | .37 | 0.72 (0.49-1.05) | .09 | 1.25 (0.87-1.80) | .22 | 1.35 (1.05-1.75) | .01 |
| Colitis | ||||||||||
| Absent | 1 | 1 | 1 | 1 | 1 | |||||
| Present | 1.72 (0.99-2.99) | .052 | 1.03 (0.65-1.63) | .87 | 0.50 (0.23-1.08) | .08 | 1.38 (0.66-2.84) | .38 | 1.24 (0.70-2.21) | .45 |
| Conditioning regimen | ||||||||||
| Bu/Flu | 1 | 1 | 1 | 1 | 1 | |||||
| Bu/Cy | 1.22 (0.62-2.39) | .54 | 0.81 (0.46-1.42) | .48 | 0.31 (0.11-0.91) | .03 | 2.13 (1.03-4.39) | .04 | 0.81 (0.43-1.52) | .52 |
| Treo/Flu | 0.83 (0.40-1.71) | .62 | 1.11 (0.68-1.81) | .67 | 1.38 (0.7459-2.56) | .30 | 1.82 (0.85-3.89) | .12 | 0.73 (0.36-1.45) | .37 |
| Treo/Flu/TT | 0.32 (0.07-1.34) | .11 | 0.62 (0.28-1.36) | .23 | 0.78 (0.30-2.03) | .62 | 1.56 (0.58-4.16) | .37 | 0.35 (0.11-1.15) | .08 |
| Other | 1.04 (0.48-2.27) | .90 | 1.62 (0.93-2.80) | .08 | 2.00 (1.001-4.01) | .04 | 1.2759 (0.43-3.77) | .65 | 1.33 (0.63-2.79) | .44 |
| Donor type | ||||||||||
| MFD | 1 | 1 | 1 | 1 | 1 | |||||
| MUD | 1.27 (0.71-2.25) | .40 | 1.89 (1.19-2.98) | .006 | 2.33 (1.19-4.57) | .01 | 1.07 (0.57-2.00) | .82 | 1.02 (0.62-1.69) | .91 |
| 1-Ag mismatch | 2.29 (1.18-4.42) | .01 | 2.37 (1.38-4.08) | .001 | 2.67 (1.22-5.87) | .01 | 1.67 (0.77-3.61) | .1 | 1.82 (0.98-3.38) | .057 |
| >1-Ag mismatch | 2.46 (0.78-7.72) | .12 | 3.69 (1.65-8.22) | .001 | 5.54 (1.92-15.99) | .001 | 0.57 (0.07-4.52) | .59 | 1.94 (0.63-5.95) | .24 |
| Stem cell source | ||||||||||
| BM | 1 | 1 | 1 | 1 | 1 | |||||
| CB | 1.05 (0.36-3.06) | .92 | 1.22 (0.57-2.61) | .60 | 1.27 (0.48-3.33) | .62 | 1.97 (0.66-5.86) | .22 | 0.61 (0.18-2.03) | .42 |
| PB | 1.02 (0.59-1.76) | .92 | 1.14 (0.76-1.71) | .51 | 1.08 (0.62-1.88) | .77 | 0.75 (0.37-1.51) | .42 | 0.82 (0.48-1.42) | .49 |
HR and 95% CI are from Cox regression analysis. Results are highlighted in bold according to the definition of significance being P < .05.
1-Ag MM, 1-antigen-mismatched donor; BM, bone marrow; Bu, busulfan; CB, cord blood; Cy, cyclophosphamide; Flu, fludarabine; PB, peripheral blood; Treo, treosulfan; TT, thiotepa.