Schematic comparison of the FAB/LMB and BFM risk-stratified chemotherapy regimens
| Risk strata . | Regimen . | Prephase . | Chemotherapy phases . | |||||
|---|---|---|---|---|---|---|---|---|
| Low risk | BFM R1 | None | A | B | ||||
| FAB/LMB group A | None | COPAD | COPAD | |||||
| Intermediate risk | BFM R2 | V | A | B | A | B | ||
| FAB/LMB group B | COP | COPADM | COPADM | CYM | CYM | |||
| BFM R3 | V | AA | BB | CC | AA | BB | ||
| High risk | FAB/LMB group C | COP | COPADM | COPADM2 | CYVE | CYVE | m1 | m2 |
| BFM R4 | V | AA | BB | CC | AA | BB | CC | |
| Risk strata . | Regimen . | Prephase . | Chemotherapy phases . | |||||
|---|---|---|---|---|---|---|---|---|
| Low risk | BFM R1 | None | A | B | ||||
| FAB/LMB group A | None | COPAD | COPAD | |||||
| Intermediate risk | BFM R2 | V | A | B | A | B | ||
| FAB/LMB group B | COP | COPADM | COPADM | CYM | CYM | |||
| BFM R3 | V | AA | BB | CC | AA | BB | ||
| High risk | FAB/LMB group C | COP | COPADM | COPADM2 | CYVE | CYVE | m1 | m2 |
| BFM R4 | V | AA | BB | CC | AA | BB | CC | |
A, cycle A; AA, cycle AA; B, cycle B; BB, cycle BB; CC, cycle CC; COP, COP pre-phase; COPADM, induction phase; COPADM2, induction phase; CYM, consolidation phase; CYVE, consolidation phase; m1, maintenance phase 1; m2, maintenance 2; V, pre-phase.