Predominant Ig and TR clonotypes in pediatric BCP-ALL
| IG/TR alleles . | 10 Predominant clonotypes . | Leukemic clonotypes* . | Reactive clonotypes† . |
|---|---|---|---|
| Total, N/n | 1645‡ | 686 | 959 |
| IgH VDJ total | 456 (27.7) | 243 (35.4) | 213 (22.2) |
| Productive, % | 30.7 | 20.9§ | 40.8¶ |
| IgH DJ | 404 (24.6) | 65 (9.5) | 339 (35.3) |
| IgK | 309 (18.8) | 113 (16.5) | 196 (20.4) |
| TRD | 476 (28.9) | 265 (38.6) | 211 (22) |
| Total patients, N | 177 | ||
| ≥1 productive IgH VDJ | 48 (27.1) | ||
| Only nonproductive IgH VDJ | 110 (62.2) | ||
| No IgH VDJ but ≥1 IgH DJ +/− IgK/TRD | 5 (2.8) | ||
| No IgH but ≥1 IgK with or without TRD | 9 (5.1) | ||
| No Ig but ≥1 TRD | 5 (2.8) |
| IG/TR alleles . | 10 Predominant clonotypes . | Leukemic clonotypes* . | Reactive clonotypes† . |
|---|---|---|---|
| Total, N/n | 1645‡ | 686 | 959 |
| IgH VDJ total | 456 (27.7) | 243 (35.4) | 213 (22.2) |
| Productive, % | 30.7 | 20.9§ | 40.8¶ |
| IgH DJ | 404 (24.6) | 65 (9.5) | 339 (35.3) |
| IgK | 309 (18.8) | 113 (16.5) | 196 (20.4) |
| TRD | 476 (28.9) | 265 (38.6) | 211 (22) |
| Total patients, N | 177 | ||
| ≥1 productive IgH VDJ | 48 (27.1) | ||
| Only nonproductive IgH VDJ | 110 (62.2) | ||
| No IgH VDJ but ≥1 IgH DJ +/− IgK/TRD | 5 (2.8) | ||
| No IgH but ≥1 IgK with or without TRD | 9 (5.1) | ||
| No Ig but ≥1 TRD | 5 (2.8) |
The 10 most frequent Ig and TR clonotypes are indicated for 177 patients with BCP-ALL aged younger than 10 years. Unless otherwise noted, data are n (%).
More than 10% of reads for a given target.
Less than 10% of reads for a given target.
A total of 106 germline IGHD7-27/J1*1, 13 TRA/B/G, and 6 atypical IgH were filtered out.
Forty of 201 (20%) clonotypes corresponding to >20% of reads for a given target vs 13 of 42 (31%) of clonotypes corresponding to 10% to 20% of reads for a given target.
Fifty-nine of 138 (43%) clonotypes corresponding to 1% to 10% of reads for a given target.