IgH clonotypes identified in diagnostic twin leukemic DNA
| Ig CDR3 . | Locus reads (%) . | IF/OF . |
|---|---|---|
| Twin A: peripheral blood 80% blasts (total 115 000 IgH VDJ and 120 000 DJ reads) | ||
| IGHV3-9*01 0/TAAGGGG/5 IGHD6-13*01 5//5 IGHJ4*02 | 42 | OF* |
| IGHV3-33*01 4/TC/0 IGHD7-27*01 0/CCTAGT/0 IGHJ4*02 | 23 | OF |
| IGHV3-9*01 8/CTTTGG/5 IGHJ6*02 | 12 | OF |
| IGHV3-21*01 0/TCCGCCG/5 IGHD6-13*01 5//5 IGHJ4*02 | 4 | OF |
| IGHV3-13*01 1/GGAAGG/4 IGHJ5*02 | 1 | OF |
| IGHV3-74*02 0/AGGGCACGC/3 IGHD6-13*01 5//5 IGHJ4*02 | 1 | OF |
| Smaller IgH VDJ and filtered reads | 16 | |
| D2-2*01 5/20/5 IGHD6-13*01 5//5 IGHJ4*02 | 8 | |
| Twin B: bone marrow 55% blasts (total 141 000 IgH VDJ and 133 000 DJ reads) | ||
| IGHV3-74*02 2/CCCGTGGG/6 IGHD6-13*01 5//5 IGHJ4*02 | 90 | OF* |
| IGHV3-30*04 0/TCCCCCCTCC/2 IGHD6-13*01 5//5 IGHJ4*02 | 3 | OF |
| Smaller IgH VDJ and filtered | 7 | |
| No frequent DJ with common IGHD6-13*01 5//5 IGHJ4*02 trunk |
| Ig CDR3 . | Locus reads (%) . | IF/OF . |
|---|---|---|
| Twin A: peripheral blood 80% blasts (total 115 000 IgH VDJ and 120 000 DJ reads) | ||
| IGHV3-9*01 0/TAAGGGG/5 IGHD6-13*01 5//5 IGHJ4*02 | 42 | OF* |
| IGHV3-33*01 4/TC/0 IGHD7-27*01 0/CCTAGT/0 IGHJ4*02 | 23 | OF |
| IGHV3-9*01 8/CTTTGG/5 IGHJ6*02 | 12 | OF |
| IGHV3-21*01 0/TCCGCCG/5 IGHD6-13*01 5//5 IGHJ4*02 | 4 | OF |
| IGHV3-13*01 1/GGAAGG/4 IGHJ5*02 | 1 | OF |
| IGHV3-74*02 0/AGGGCACGC/3 IGHD6-13*01 5//5 IGHJ4*02 | 1 | OF |
| Smaller IgH VDJ and filtered reads | 16 | |
| D2-2*01 5/20/5 IGHD6-13*01 5//5 IGHJ4*02 | 8 | |
| Twin B: bone marrow 55% blasts (total 141 000 IgH VDJ and 133 000 DJ reads) | ||
| IGHV3-74*02 2/CCCGTGGG/6 IGHD6-13*01 5//5 IGHJ4*02 | 90 | OF* |
| IGHV3-30*04 0/TCCCCCCTCC/2 IGHD6-13*01 5//5 IGHJ4*02 | 3 | OF |
| Smaller IgH VDJ and filtered | 7 | |
| No frequent DJ with common IGHD6-13*01 5//5 IGHJ4*02 trunk |
The most frequent IgH clonotypes and their relative frequency, as a percentage of total reads for the given locus, are shown. The shared IGHD6-J4 common stem rearrangement is set italic.
IF, in-frame; OF, out-of-frame
CDR3 targets for minimal residual disease quantification by quantitative polymerase chain reaction.