Characterization of clones representing more than 2% in the BCR repertoires (including stop codons)
| . | Percentage of repertoire . | V gene . | D gene . | J gene . | SHM in V gene . | STOP codon present? . | CDR3 sequence (nucleotides) . | Predicted CDR3 sequence based on in-frame IGHV gene (amino acids) . |
|---|---|---|---|---|---|---|---|---|
| Twin A | 14.95 | IGHV3-33*01/06 | IGHD7-27*01 | IGHJ4*02 | 0 | Yes | GCGATCCTAACTGGGGACCTAGTACTACTTTGACTAC | AILTGDLVLL*L |
| Twin A | 14.41 | IGHV3- 9*01 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCAAAAGATATAAGGGGTAGCAGCAGCTTTTGACTAC | AKDIRGSSSF*L |
| Twin A | 2.45 | IGHV3-21*01/02 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCGAGAGATCCGCCGTAGCAGCAGCTTTTGACTAC | ARDPP*QQLLTT |
| Twin B | 28.36 | IGHV3-74*01/02 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCAACCCGTGGGAGCAGCAGCTTTTGACTAC | ATRGSSSF*L |
| Twin B | 3.12 | IGHV3-30*04/03 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCGAGAGATCCCCCCTCCGTATAGCAGCAGCTTTTGACTAC | ARDPPSV*QQLLTT |
| . | Percentage of repertoire . | V gene . | D gene . | J gene . | SHM in V gene . | STOP codon present? . | CDR3 sequence (nucleotides) . | Predicted CDR3 sequence based on in-frame IGHV gene (amino acids) . |
|---|---|---|---|---|---|---|---|---|
| Twin A | 14.95 | IGHV3-33*01/06 | IGHD7-27*01 | IGHJ4*02 | 0 | Yes | GCGATCCTAACTGGGGACCTAGTACTACTTTGACTAC | AILTGDLVLL*L |
| Twin A | 14.41 | IGHV3- 9*01 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCAAAAGATATAAGGGGTAGCAGCAGCTTTTGACTAC | AKDIRGSSSF*L |
| Twin A | 2.45 | IGHV3-21*01/02 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCGAGAGATCCGCCGTAGCAGCAGCTTTTGACTAC | ARDPP*QQLLTT |
| Twin B | 28.36 | IGHV3-74*01/02 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCAACCCGTGGGAGCAGCAGCTTTTGACTAC | ATRGSSSF*L |
| Twin B | 3.12 | IGHV3-30*04/03 | IGHD6-13*01 | IGHJ4*02 | 0 | Yes | GCGAGAGATCCCCCCTCCGTATAGCAGCAGCTTTTGACTAC | ARDPPSV*QQLLTT |
SHM, somatic hypermutation.