Definitions of relapsed and refractory AML
| Category . | Definition . |
|---|---|
| PIF (PRD) | Lack of CR or CRi following at least 2 cycles of intensive chemotherapy |
| Hematologic relapse | Detection of ≥5% blasts in the BM, identification of circulating blasts, or emergence of extramedullary disease |
| MRD | Detection of MRD defined by molecular techniques or multiparameter flow cytometry after an MRD− CR |
| Category . | Definition . |
|---|---|
| PIF (PRD) | Lack of CR or CRi following at least 2 cycles of intensive chemotherapy |
| Hematologic relapse | Detection of ≥5% blasts in the BM, identification of circulating blasts, or emergence of extramedullary disease |
| MRD | Detection of MRD defined by molecular techniques or multiparameter flow cytometry after an MRD− CR |
Modified from the ELN guidelines in Döhner et al.14
BM, bone marrow; CR, complete remission; CRi, CR with incomplete hematologic recovery; MRD, minimal/measurable residual disease.