Clinical variables of the tested subjects with HbSS SCD
| . | Group 1 (n = 34) . | Group 2 (n = 21) . | P . |
|---|---|---|---|
| Age, y | 37.8 ± 13.6 | 35.9 ± 13.0 | .628** |
| Hemoglobin, g/dL | 8.6 ± 1.4 | 8.6 ± 1.3 | .965** |
| Mean corpuscular volume, fL | 96.7 ± 14.2 | 92.6 ± 5.4 | .222* |
| Platelets, ×109/L | 313.7 ± 140.9 | 364.3 ± 89.4 | .147* |
| WBC count, ×109/L | 9.6 ± 3.2 | 12.7 ± 3.8 | .002* |
| Absolute neutrophil count, ×106/L | 5514 ± 2303 | 7359 ± 2841 | .014* |
| ARC, ×109/L | 214.7 ± 89.1 | 482.2 ± 174.9 | <.001* |
| LDH, U/L | 271.9 ± 64.0 | 510.0 ± 200.2 | <.001* |
| Ferritin, μg/L | 2680.2 ± 2626.3 | 1920.4 ± 2179.3 | .472* |
| Hemoglobin S, % | 58.5 ± 23.7 | 56.5 ± 20.2 | .523* |
| Hemoglobin A, % | 25.8 ± 24.6 | 30.0 ± 21.8 | .601* |
| Hemoglobin F, % | 8.2 ± 7.6 | 4.1 ± 4.3 | .143* |
| . | Group 1 (n = 34) . | Group 2 (n = 21) . | P . |
|---|---|---|---|
| Age, y | 37.8 ± 13.6 | 35.9 ± 13.0 | .628** |
| Hemoglobin, g/dL | 8.6 ± 1.4 | 8.6 ± 1.3 | .965** |
| Mean corpuscular volume, fL | 96.7 ± 14.2 | 92.6 ± 5.4 | .222* |
| Platelets, ×109/L | 313.7 ± 140.9 | 364.3 ± 89.4 | .147* |
| WBC count, ×109/L | 9.6 ± 3.2 | 12.7 ± 3.8 | .002* |
| Absolute neutrophil count, ×106/L | 5514 ± 2303 | 7359 ± 2841 | .014* |
| ARC, ×109/L | 214.7 ± 89.1 | 482.2 ± 174.9 | <.001* |
| LDH, U/L | 271.9 ± 64.0 | 510.0 ± 200.2 | <.001* |
| Ferritin, μg/L | 2680.2 ± 2626.3 | 1920.4 ± 2179.3 | .472* |
| Hemoglobin S, % | 58.5 ± 23.7 | 56.5 ± 20.2 | .523* |
| Hemoglobin A, % | 25.8 ± 24.6 | 30.0 ± 21.8 | .601* |
| Hemoglobin F, % | 8.2 ± 7.6 | 4.1 ± 4.3 | .143* |
A total of 106 blood samples were obtained from 55 patients with homozygous HbSS (29 males and 26 females); the mean value was used for a subject tested more than once. Data are mean ± standard deviation. P values that represent a statistically significant difference between group 1 and 2 are denoted with boldface.
Nonparametric Mann-Whitney U test.
Parametric 1-way analysis of variance (ANOVA).