Definition and criteria for grading cancer-associated anemia
| Anemia grade . | CTCAE + WHO Criteria . | |
|---|---|---|
| Women . | Men . | |
| Grade 1 | Hb 11.9-10.0 g/dL | Hb 12.9-10.0 g/dL |
| Grade 2 | Hb 9.9-8.0 g/dL | Hb 9.9-8.0 g/dL |
| Grade 3 | Hb ≤7.9 g/dL | Hb <7.9 g/dL |
| Grade 4 | Life-threatening consequences requiring urgent intervention, such as RBC transfusion | Life-threatening consequences requiring urgent intervention, such as RBC transfusion |
| Anemia grade . | CTCAE + WHO Criteria . | |
|---|---|---|
| Women . | Men . | |
| Grade 1 | Hb 11.9-10.0 g/dL | Hb 12.9-10.0 g/dL |
| Grade 2 | Hb 9.9-8.0 g/dL | Hb 9.9-8.0 g/dL |
| Grade 3 | Hb ≤7.9 g/dL | Hb <7.9 g/dL |
| Grade 4 | Life-threatening consequences requiring urgent intervention, such as RBC transfusion | Life-threatening consequences requiring urgent intervention, such as RBC transfusion |
By using World Health Organization (WHO) criteria and the CTCAE (v5.0) grading system for anemia, a definition for cancer-associated anemia was established: grade 1 anemia was defined as Hb ≤11.9 g/dL for women with cancer and Hb ≤12.9 g/dL for men with cancer. Severity of anemia increases with increasing grade up to grade 5 (death).