Association of complete count recovery at 1 month from CAR T-cell infusion and grade ≥3 CRS or ICANS with adjustment for baseline cytopenia and CAR construct
| . | ≤Grade 2 CRS or ICANS (n = 50) . | Grade 3-4 CRS or ICANS (n = 33) . | P* . |
|---|---|---|---|
| Baseline cytopenia | .002 | ||
| No (n = 10) | 5/7 (71) | 1/3 (33) | |
| Yes (n = 73) | 13/43 (30) | 1/30 (3) | |
| CAR construct | .01 | ||
| Axicabtagene ciloleucel (n = 30) | 5/19 (26) | 0/11 (0) | |
| Tisagenlecleucel (n = 10) | 7/10 (70) | 0/0 | |
| 19-28z CAR T cells (n = 37) | 6/16 (38) | 1/21 (5) | |
| anti-BCMA CAR T cells (n = 6) | 0/5 (0) | 1/1 (100) |
| . | ≤Grade 2 CRS or ICANS (n = 50) . | Grade 3-4 CRS or ICANS (n = 33) . | P* . |
|---|---|---|---|
| Baseline cytopenia | .002 | ||
| No (n = 10) | 5/7 (71) | 1/3 (33) | |
| Yes (n = 73) | 13/43 (30) | 1/30 (3) | |
| CAR construct | .01 | ||
| Axicabtagene ciloleucel (n = 30) | 5/19 (26) | 0/11 (0) | |
| Tisagenlecleucel (n = 10) | 7/10 (70) | 0/0 | |
| 19-28z CAR T cells (n = 37) | 6/16 (38) | 1/21 (5) | |
| anti-BCMA CAR T cells (n = 6) | 0/5 (0) | 1/1 (100) |
Data are number with complete count recovery at 1 month/total number of patients (% recovered).
Cochran-Mantel-Haenszel test.