Prognostic factors for outcome in 217 patients with CNS disease
| . | CNS+, n (%) of patients . | 5-y EFS, % . | Univariate analyses, P . |
|---|---|---|---|
| Sex | |||
| Female | 34 (16) | 91 | .10 |
| Male | 183 (84) | 80 | |
| Age (median age: 8.4 y), y | |||
| <9 | 120 (55) | 82 | .55 |
| ≥9 | 97 (45) | 80 | |
| Histology | |||
| BL/B-LL | 191 (88) | 80 | .19 |
| DLBCL | 14 (6) | 100 | |
| B high-grade NOS | 12 (6) | 92 | |
| LDH levels* | |||
| LDH <2N | 57 (27) | 95 | .002 |
| LDH ≥2N | 151 (73) | 76 | |
| CSF status (including isolated CSF; n = 54) | |||
| Negative | 120 (55) | 90 | .0007 |
| Positive | 97 (45) | 71 | |
| CNP (including isolated CNP; n = 34) | |||
| No | 125 (58) | 83 | .40 |
| Yes | 92 (42) | 79 | |
| Spinal cord compression (including isolated spinal cord compression; n = 4) | |||
| No | 187 (86) | 82 | .56 |
| Yes | 30 (14) | 77 | |
| ICM†(including isolated ICM; n = 7) | |||
| No | 190 (88) | 80 | .13 |
| Yes | 25 (12) | 92 | |
| PME (including isolated PME; n = 28) | |||
| No | 149 (69) | 82 | .97 |
| Yes | 68 (31) | 81 | |
| BM involvement | |||
| No | 84 (39) | 81 | .77 |
| Yes | 133 (61) | 78 | |
| COP response | |||
| Poor response (<20%) | 11 (5) | 45 | .0008 |
| Good response (>20%) | 206 (95) | 83 |
| . | CNS+, n (%) of patients . | 5-y EFS, % . | Univariate analyses, P . |
|---|---|---|---|
| Sex | |||
| Female | 34 (16) | 91 | .10 |
| Male | 183 (84) | 80 | |
| Age (median age: 8.4 y), y | |||
| <9 | 120 (55) | 82 | .55 |
| ≥9 | 97 (45) | 80 | |
| Histology | |||
| BL/B-LL | 191 (88) | 80 | .19 |
| DLBCL | 14 (6) | 100 | |
| B high-grade NOS | 12 (6) | 92 | |
| LDH levels* | |||
| LDH <2N | 57 (27) | 95 | .002 |
| LDH ≥2N | 151 (73) | 76 | |
| CSF status (including isolated CSF; n = 54) | |||
| Negative | 120 (55) | 90 | .0007 |
| Positive | 97 (45) | 71 | |
| CNP (including isolated CNP; n = 34) | |||
| No | 125 (58) | 83 | .40 |
| Yes | 92 (42) | 79 | |
| Spinal cord compression (including isolated spinal cord compression; n = 4) | |||
| No | 187 (86) | 82 | .56 |
| Yes | 30 (14) | 77 | |
| ICM†(including isolated ICM; n = 7) | |||
| No | 190 (88) | 80 | .13 |
| Yes | 25 (12) | 92 | |
| PME (including isolated PME; n = 28) | |||
| No | 149 (69) | 82 | .97 |
| Yes | 68 (31) | 81 | |
| BM involvement | |||
| No | 84 (39) | 81 | .77 |
| Yes | 133 (61) | 78 | |
| COP response | |||
| Poor response (<20%) | 11 (5) | 45 | .0008 |
| Good response (>20%) | 206 (95) | 83 |
Bold P values are statistically significant (P < .05).
BL/BLL, Burkitt lymphoma/Burkitt-like lymphoma; COP, cyclophosphamide, oncovin (vincristine), prednisone; DLBCL, diffuse large B-cell lymphoma; PME, parameningeal extension.
LDH level was available for 208 out of 217 patients.
ICM status was available for 215 out of 217 patients.