CNS disease according to patient characteristics and B-NHL subtype
| . | Total no. of patients . | CNS+, n (%) of patients . | CNS−, n (%) of patients . | CNS− vs CNS+, P . |
|---|---|---|---|---|
| Study | 1690 | 217 (13) | 1473 (87) | .73 |
| LMB89 | 561 | 67 (12) | 494 (88) | |
| LMB96 (SFOP only) | 384 | 52 (14) | 332 (86) | |
| LMB2001 | 745 | 98 (13) | 647 (87) | |
| Sex | .007 | |||
| Male | 1303 | 183 (84) | 1120 (76) | |
| Age, y | .67 | |||
| >15 | 158 | 22 (10) | 136 (9) | |
| Histology* | .0003 | |||
| BL/B-LL | 1327 | 191 (88) | 1136 (77) | |
| DLBCL | 262 | 14 (6) | 248 (17) | |
| B high-grade NOS | 99 | 12 (6) | 87 (6) | |
| Primary site | <.0001 | |||
| Head and neck | 311 | 65 (30) | 246 (17) | |
| Abdomen | 916 | 50 (23) | 866 (59) | |
| Other | 463 | 102 (47) | 361 (25) | |
| BM involvement, % † | <.0001 | |||
| No | 1281 | 84 (39) | 1197 (81) | |
| 1-25 | 111 | 21 (10) | 90 (6) | |
| >25 | 296 | 112 (52) | 184 (13) | |
| LDH‡ | <.0001 | |||
| LDH >2N | 787 | 151 (73) | 636 (45) |
| . | Total no. of patients . | CNS+, n (%) of patients . | CNS−, n (%) of patients . | CNS− vs CNS+, P . |
|---|---|---|---|---|
| Study | 1690 | 217 (13) | 1473 (87) | .73 |
| LMB89 | 561 | 67 (12) | 494 (88) | |
| LMB96 (SFOP only) | 384 | 52 (14) | 332 (86) | |
| LMB2001 | 745 | 98 (13) | 647 (87) | |
| Sex | .007 | |||
| Male | 1303 | 183 (84) | 1120 (76) | |
| Age, y | .67 | |||
| >15 | 158 | 22 (10) | 136 (9) | |
| Histology* | .0003 | |||
| BL/B-LL | 1327 | 191 (88) | 1136 (77) | |
| DLBCL | 262 | 14 (6) | 248 (17) | |
| B high-grade NOS | 99 | 12 (6) | 87 (6) | |
| Primary site | <.0001 | |||
| Head and neck | 311 | 65 (30) | 246 (17) | |
| Abdomen | 916 | 50 (23) | 866 (59) | |
| Other | 463 | 102 (47) | 361 (25) | |
| BM involvement, % † | <.0001 | |||
| No | 1281 | 84 (39) | 1197 (81) | |
| 1-25 | 111 | 21 (10) | 90 (6) | |
| >25 | 296 | 112 (52) | 184 (13) | |
| LDH‡ | <.0001 | |||
| LDH >2N | 787 | 151 (73) | 636 (45) |