Toxicity per course of treatment
| . | Grade 1-2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . | Grade 5 . |
|---|---|---|---|---|
| Neutropenia | 9 (7) | 17 (13) | 57 (43) | — |
| Thrombocytopenia | 34 (26) | 25 (19) | 26 (20) | — |
| Anemia | 86 (65) | 12 (9) | 2 (2) | — |
| Febrile neutropenia | — | 5 (4) | 1 (1) | — |
| Hepatotoxicity | 27 (20) | 4 (3) | 1 (1) | — |
| Oral mucositis | 1 (1) | 3 (2) | — | — |
| Infections | — | 5 (4) | — | — |
| Seizures | 3 (2) | — | — | — |
| Deep vein thrombosis | 2 (2) | — | — | — |
| Syncope | — | 2 (2) | — | — |
| LVEF reduction | 1 (1) | — | — | — |
| Constipation | 2 (2) | 1 (1) | — | — |
| Nausea and vomiting | 4 (3) | — | — | — |
| TNF infusion reaction* | 9 (7) | — | — | — |
| . | Grade 1-2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . | Grade 5 . |
|---|---|---|---|---|
| Neutropenia | 9 (7) | 17 (13) | 57 (43) | — |
| Thrombocytopenia | 34 (26) | 25 (19) | 26 (20) | — |
| Anemia | 86 (65) | 12 (9) | 2 (2) | — |
| Febrile neutropenia | — | 5 (4) | 1 (1) | — |
| Hepatotoxicity | 27 (20) | 4 (3) | 1 (1) | — |
| Oral mucositis | 1 (1) | 3 (2) | — | — |
| Infections | — | 5 (4) | — | — |
| Seizures | 3 (2) | — | — | — |
| Deep vein thrombosis | 2 (2) | — | — | — |
| Syncope | — | 2 (2) | — | — |
| LVEF reduction | 1 (1) | — | — | — |
| Constipation | 2 (2) | 1 (1) | — | — |
| Nausea and vomiting | 4 (3) | — | — | — |
| TNF infusion reaction* | 9 (7) | — | — | — |
All toxic events other than alopecia are reported. The denominator is the total number of delivered courses (n = 132).
LVEF, left ventricular ejection fraction.
Fever (4), chills (4), arterial hypertension (1).