Summary of HD-MTX toxicity
| Parameter . | All (N = 729) . | Intercalated (n = 409) . | EOT (n = 320) . | P . |
|---|---|---|---|---|
| No. of inpatient days, median (range) | 5 (2-60) | 5 (2-60) | 4 (3-80) | <.001* |
| Toxicity | ||||
| Renal (any) | 38 (5) | 21 (5) | 17 (5) | .92 |
| Grade 1 (creatinine 1.5-1.9 × baseline) | 22 (3) | 12 (3) | 10 (3) | |
| Grade 2 (creatinine 2-2.9 × baseline) | 6 (1) | 3 (1) | 3 (1) | |
| Grade 3 (creatinine >3 × baseline) | 10 (1) | 6 (1) | 4 (1) | |
| Liver (grade 2 or worse) | 17 (2) | 7 (2) | 10 (3) | .21 |
| Mucositis | 54 (7) | 42 (10) | 12 (4) | .001* |
| Neutropenic fever | 49 (7) | 42 (10) | 7 (2) | <.001* |
| Parameter . | All (N = 729) . | Intercalated (n = 409) . | EOT (n = 320) . | P . |
|---|---|---|---|---|
| No. of inpatient days, median (range) | 5 (2-60) | 5 (2-60) | 4 (3-80) | <.001* |
| Toxicity | ||||
| Renal (any) | 38 (5) | 21 (5) | 17 (5) | .92 |
| Grade 1 (creatinine 1.5-1.9 × baseline) | 22 (3) | 12 (3) | 10 (3) | |
| Grade 2 (creatinine 2-2.9 × baseline) | 6 (1) | 3 (1) | 3 (1) | |
| Grade 3 (creatinine >3 × baseline) | 10 (1) | 6 (1) | 4 (1) | |
| Liver (grade 2 or worse) | 17 (2) | 7 (2) | 10 (3) | .21 |
| Mucositis | 54 (7) | 42 (10) | 12 (4) | .001* |
| Neutropenic fever | 49 (7) | 42 (10) | 7 (2) | <.001* |
Data are n (%) unless otherwise noted.
*Statistically significant.