Univariable and multivariable analysis of factors associated with R-CHOP delays in whole study population
| Parameter . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |
| i-HD-MTX | 2.64 (1.48-4.72) | .001* | 3.06 (1.62-5.77) | .001* |
| Age | 1.01 (0.99-1.03) | .58 | 1.00 (0.97-1.03) | .88 |
| Baseline creatinine clearance | 1.00 (0.99-1.01) | .78 | 1.00 (0.99-1.01) | .39 |
| Male sex | 1.60 (0.95-2.70) | .08* | 1.84 (1.04-3.26) | .04* |
| Advanced stage | 0.82 (0.43-1.56) | .54 | 0.69 (0.29-1.63) | .40 |
| ECOG PS ≥2 | 0.81 (0.45-1.43) | .46 | 0.86 (0.46-1.60) | .63 |
| ≥2 extranodal sites | 1.23 (0.73-2.07) | .44 | 1.76 (0.89-3.45) | .10 |
| Elevated LDH | 0.91 (0.51-1.60) | .73 | 0.94 (0.50-1.91) | .94 |
| IT therapy given | 0.63 (0.38-1.06) | .08 | 0.74 (0.42-1.30) | .29 |
| HD-MTX dose | 0.76 (0.45-1.30) | .31 | 0.65 (0.37-1.16) | .14 |
| Parameter . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |
| i-HD-MTX | 2.64 (1.48-4.72) | .001* | 3.06 (1.62-5.77) | .001* |
| Age | 1.01 (0.99-1.03) | .58 | 1.00 (0.97-1.03) | .88 |
| Baseline creatinine clearance | 1.00 (0.99-1.01) | .78 | 1.00 (0.99-1.01) | .39 |
| Male sex | 1.60 (0.95-2.70) | .08* | 1.84 (1.04-3.26) | .04* |
| Advanced stage | 0.82 (0.43-1.56) | .54 | 0.69 (0.29-1.63) | .40 |
| ECOG PS ≥2 | 0.81 (0.45-1.43) | .46 | 0.86 (0.46-1.60) | .63 |
| ≥2 extranodal sites | 1.23 (0.73-2.07) | .44 | 1.76 (0.89-3.45) | .10 |
| Elevated LDH | 0.91 (0.51-1.60) | .73 | 0.94 (0.50-1.91) | .94 |
| IT therapy given | 0.63 (0.38-1.06) | .08 | 0.74 (0.42-1.30) | .29 |
| HD-MTX dose | 0.76 (0.45-1.30) | .31 | 0.65 (0.37-1.16) | .14 |
*Statistically significant.