Univariable and multivariable analysis of factors influencing delay of subsequent R-CHOP when i-HD-MTX given
| Parameter . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |
| i-HD-MTX given after day 9 post R-CHOP | 1.92 (1.16-3.16) | .01* | 1.74 (1.03-2.93) | .04* |
| Age | 1.02 (1.00-1.04) | .07 | 1.02 (0.99-1.05) | .16 |
| Male sex | 1.41 (0.86-2.32) | .17 | 1.50 (0.88-2.56) | .13 |
| Advanced stage | 0.61 (0.34-1.11) | .11 | 0.56 (0.26-1.21) | .14 |
| ECOG PS ≥2 | 0.84 (0.52-1.71) | .84 | 0.98 (0.52-1.84) | .94 |
| No. extranodal sites | 0.95 (0.74-1.20) | .65 | 1.00 (0.76-1.33) | .98 |
| Elevated LDH | 1.12 (0.65-1.93) | .70 | 1.72 (0.87-3.40) | .12 |
| Baseline creatinine clearance | 1.00 (0.99-1.00) | .16 | 1.00 (0.99-1.01) | .80 |
| Parameter . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |
| i-HD-MTX given after day 9 post R-CHOP | 1.92 (1.16-3.16) | .01* | 1.74 (1.03-2.93) | .04* |
| Age | 1.02 (1.00-1.04) | .07 | 1.02 (0.99-1.05) | .16 |
| Male sex | 1.41 (0.86-2.32) | .17 | 1.50 (0.88-2.56) | .13 |
| Advanced stage | 0.61 (0.34-1.11) | .11 | 0.56 (0.26-1.21) | .14 |
| ECOG PS ≥2 | 0.84 (0.52-1.71) | .84 | 0.98 (0.52-1.84) | .94 |
| No. extranodal sites | 0.95 (0.74-1.20) | .65 | 1.00 (0.76-1.33) | .98 |
| Elevated LDH | 1.12 (0.65-1.93) | .70 | 1.72 (0.87-3.40) | .12 |
| Baseline creatinine clearance | 1.00 (0.99-1.00) | .16 | 1.00 (0.99-1.01) | .80 |
Missing data: day of i-HD-MTX, n = 17.
*Statistically significant.