Univariate and multivariate analysis of clinicopathological and imaging parameters for PFS and OS in FL patients (Cox proportional hazards model, n = 261)
| . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|
| PFS P . | OS P . | PFS P . | HR (95% CI) . | OS P . | HR (95% CI) . | |
| Sex | ||||||
| Male vs female | .92 | .10 | N/A | N/A | .18 | N/A |
| Grade | ||||||
| 1,2 vs 3A | .74 | .25 | N/A | N/A | N/A | N/A |
| Score, >2 vs ≤2 | ||||||
| FLIPI | .03 | .005 | .18 | N/A | .03 | 2.24 (1.07-4.70) |
| FLIPI-2 (79 patients) | .58 | .02 | Not entered | Not entered | Not entered | Not entered |
| Result, positive vs negative | ||||||
| Focal BM FDG uptake | .001 | <.001 | <.001 | 2.30 (1.42-3.71) | .002 | 3.31 (1.57-6.98) |
| BMB | .025 | .07 | .21 | N/A | .61 | N/A |
| Combined focal BM FDG uptake and BMB | .05 | .01 | Not entered | Not entered | Not entered | Not entered |
| . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|
| PFS P . | OS P . | PFS P . | HR (95% CI) . | OS P . | HR (95% CI) . | |
| Sex | ||||||
| Male vs female | .92 | .10 | N/A | N/A | .18 | N/A |
| Grade | ||||||
| 1,2 vs 3A | .74 | .25 | N/A | N/A | N/A | N/A |
| Score, >2 vs ≤2 | ||||||
| FLIPI | .03 | .005 | .18 | N/A | .03 | 2.24 (1.07-4.70) |
| FLIPI-2 (79 patients) | .58 | .02 | Not entered | Not entered | Not entered | Not entered |
| Result, positive vs negative | ||||||
| Focal BM FDG uptake | .001 | <.001 | <.001 | 2.30 (1.42-3.71) | .002 | 3.31 (1.57-6.98) |
| BMB | .025 | .07 | .21 | N/A | .61 | N/A |
| Combined focal BM FDG uptake and BMB | .05 | .01 | Not entered | Not entered | Not entered | Not entered |
Final PFS and OS model contains focal BM FDG uptake result only. The other P values show the results of other variables added one-by-one to the final model. FLIPI-2 was not entered in the multivariate model due to the high percentage of missing values (70%); the combined focal BM FDG uptake result and the BMB result were not entered due to high correlation with FDG uptake and BMB results.