Relation ternary complex formation and hemostatic potential
| Emicizumab, mg/kg . | FIX, U/kg . | FX, U/kg . | Estimated ternary complex, pM . | Reduced blood loss? . |
|---|---|---|---|---|
| 0 | 100 | 100 | 0 | No |
| 5 | 0 | 100 | 0 | No |
| 5 | 100 | 0 | 0 | No |
| 0.5 | 100 | 100 | 129 | No |
| 1 | 100 | 100 | 333 | Yes |
| 3 | 100 | 100 | 748 | Yes |
| 5 | 100 | 100 | 1001 | Yes |
| 10 | 100 | 100 | 1270 | Yes |
| 5 | 25 | 25 | 66 | No |
| 5 | 50 | 50 | 258 | Yes |
| 5 | 200 | 100 | 1961 | Yes |
| Emicizumab, mg/kg . | FIX, U/kg . | FX, U/kg . | Estimated ternary complex, pM . | Reduced blood loss? . |
|---|---|---|---|---|
| 0 | 100 | 100 | 0 | No |
| 5 | 0 | 100 | 0 | No |
| 5 | 100 | 0 | 0 | No |
| 0.5 | 100 | 100 | 129 | No |
| 1 | 100 | 100 | 333 | Yes |
| 3 | 100 | 100 | 748 | Yes |
| 5 | 100 | 100 | 1001 | Yes |
| 10 | 100 | 100 | 1270 | Yes |
| 5 | 25 | 25 | 66 | No |
| 5 | 50 | 50 | 258 | Yes |
| 5 | 200 | 100 | 1961 | Yes |