Patient and graft characteristics (N = 44)
Variables . | Value . |
---|---|
Patient characteristics | |
Age, median (range), y | 1.7 (0.4-16.6) |
Weight, median (range), kg | 12 (6-74) |
Male sex, n (%) | 27 (61) |
Race, n (%) | |
White | 29 (66) |
African American | 8 (18) |
Hispanic | 3 (7) |
Asian | 1 (2) |
Alaska Native | 1 (2) |
2 or more races | 2 (5) |
Diagnosis, n (%) | |
Krabbe disease | 13 (30) |
Metachromatic leukodystrophy | 7 (16) |
Sickle cell disease | 3 (7) |
Gaucher disease | 2 (5) |
Hunter syndrome (MPS type II) | 2 (5) |
MHC class II deficiency | 2 (5) |
Osteopetrosis | 2 (5) |
XLP2 | 2 (5) |
β-thalassemia | 1 (2) |
Cartilage-hair hypoplasia | 1 (2) |
Chédiak-Higashi syndrome | 1 (2) |
Combined immunodeficiency with multiple intestinal atresias | 1 (2) |
Diamond-Blackfan anemia | 1 (2) |
GM3 synthase deficiency | 1 (2) |
Hemophagocytic lymphohistiocytosis | 1 (2) |
Hurler syndrome (MPS type IH) | 1 (2) |
Severe congenital neutropenia | 1 (2) |
Tay-Sachs disease | 1 (2) |
X-linked adrenoleukodystrophy | 1 (2) |
CMV serostatus, seropositive | 16 (36) |
Graft characteristics | |
HLA match (of 6), n (%) | |
6 | 16 (36) |
5 | 19 (43) |
4 | 9 (21) |
HLA match (of 8), n (%) | |
8 | 8 (18) |
7 | 10 (23) |
6 | 14 (32) |
5 | 10 (23) |
4 | 2 (5) |
TNC/kg, median (range), ×107 | 9.1 (2.3-24.8) |
CD34/kg, median (range), ×105 | 3.31 (0.92-9.24) |
Sex mismatch, n (%) | 22 (50) |
ABO mismatch, n (%) | 28 (64) |
Variables . | Value . |
---|---|
Patient characteristics | |
Age, median (range), y | 1.7 (0.4-16.6) |
Weight, median (range), kg | 12 (6-74) |
Male sex, n (%) | 27 (61) |
Race, n (%) | |
White | 29 (66) |
African American | 8 (18) |
Hispanic | 3 (7) |
Asian | 1 (2) |
Alaska Native | 1 (2) |
2 or more races | 2 (5) |
Diagnosis, n (%) | |
Krabbe disease | 13 (30) |
Metachromatic leukodystrophy | 7 (16) |
Sickle cell disease | 3 (7) |
Gaucher disease | 2 (5) |
Hunter syndrome (MPS type II) | 2 (5) |
MHC class II deficiency | 2 (5) |
Osteopetrosis | 2 (5) |
XLP2 | 2 (5) |
β-thalassemia | 1 (2) |
Cartilage-hair hypoplasia | 1 (2) |
Chédiak-Higashi syndrome | 1 (2) |
Combined immunodeficiency with multiple intestinal atresias | 1 (2) |
Diamond-Blackfan anemia | 1 (2) |
GM3 synthase deficiency | 1 (2) |
Hemophagocytic lymphohistiocytosis | 1 (2) |
Hurler syndrome (MPS type IH) | 1 (2) |
Severe congenital neutropenia | 1 (2) |
Tay-Sachs disease | 1 (2) |
X-linked adrenoleukodystrophy | 1 (2) |
CMV serostatus, seropositive | 16 (36) |
Graft characteristics | |
HLA match (of 6), n (%) | |
6 | 16 (36) |
5 | 19 (43) |
4 | 9 (21) |
HLA match (of 8), n (%) | |
8 | 8 (18) |
7 | 10 (23) |
6 | 14 (32) |
5 | 10 (23) |
4 | 2 (5) |
TNC/kg, median (range), ×107 | 9.1 (2.3-24.8) |
CD34/kg, median (range), ×105 | 3.31 (0.92-9.24) |
Sex mismatch, n (%) | 22 (50) |
ABO mismatch, n (%) | 28 (64) |
MHC, major histocompatibility complex; MPS, mucopolysaccharidosis; TNC, total nucleated cell; XLP2, X-linked lymphoproliferative syndrome type 2.