Baseline characteristics of POEMS patients with singular vs recurrent IS
| Characteristic . | Recurrent IS (n = 13) . | Singular IS (n = 28) . | P . |
|---|---|---|---|
| Atherosclerotic risk factors, n (%) | |||
| Hypertension | 5 (38.5) | 4 (14.3) | .182 |
| Hyperlipidemia | 2 (15.4) | 1 (3.6) | .479 |
| Diabetes | 0 (0) | 6 (21.4) | .152 |
| Smoking | 1 (7.7) | 3 (10.7) | 1.000 |
| Other ICVE risk factors | |||
| Congestive heart failure, n (%) | 2 (15.4) | 0 (0) | .095 |
| Cardiovascular disease, n (%) | 2 (15.4) | 0 (0) | .095 |
| Cardiac arrhythmias, n (%) | 0 (0) | 0 (0) | 1.000 |
| Intracardiac thrombosis, n/N | 0/11 | 0/16 | 1.000 |
| Presence of thrombophilia, n/N | 0/9 | NA | |
| Framingham Stroke Risk Profile score, median (range) | 5 (0-10) | 2 (0-10) | .694 |
| POEMS features | |||
| Age >50 y, n (%) | 7 (53.8) | 19 (67.9) | .386 |
| eGFR <30 mL/min/1.73m2, n (%) | 0 (0) | 1 (3.6) | 1.000 |
| Pulmonary hypertension (sPAP ≥50 mmHg), n/N (%) | 1/11 (9.1) | 8/21 (38.1) | .187 |
| Pleural effusion, n (%) | 5 (38.5) | 13/27 (48.1) | .564 |
| Symptom to diagnosis, median (range). mo | 7 (1-36) | 16 (3-249) | .009 |
| Male sex, n (%) | 10 (76.9) | 17 (60.7) | .308 |
| Serum VEGF, median (range), pg/mL | 4 624 (187-11 129) | 3 115 (325-8 138) (n = 17) | .133 |
| Polyneuropathy, ONLS score >4, n/N (%) | 6/10 (60.0) (n = 10) | 12/22 (54.5) | .773 |
| Platelets, median (range), ×109/L | 362 (215-731) | 232 (58-594) (n = 20) | .041 |
| Fibrinogen, median (range), g/L | 4.0 (2-7.7) (n = 12) | 3.8 (2.6-5.35) | .414 |
| Characteristic . | Recurrent IS (n = 13) . | Singular IS (n = 28) . | P . |
|---|---|---|---|
| Atherosclerotic risk factors, n (%) | |||
| Hypertension | 5 (38.5) | 4 (14.3) | .182 |
| Hyperlipidemia | 2 (15.4) | 1 (3.6) | .479 |
| Diabetes | 0 (0) | 6 (21.4) | .152 |
| Smoking | 1 (7.7) | 3 (10.7) | 1.000 |
| Other ICVE risk factors | |||
| Congestive heart failure, n (%) | 2 (15.4) | 0 (0) | .095 |
| Cardiovascular disease, n (%) | 2 (15.4) | 0 (0) | .095 |
| Cardiac arrhythmias, n (%) | 0 (0) | 0 (0) | 1.000 |
| Intracardiac thrombosis, n/N | 0/11 | 0/16 | 1.000 |
| Presence of thrombophilia, n/N | 0/9 | NA | |
| Framingham Stroke Risk Profile score, median (range) | 5 (0-10) | 2 (0-10) | .694 |
| POEMS features | |||
| Age >50 y, n (%) | 7 (53.8) | 19 (67.9) | .386 |
| eGFR <30 mL/min/1.73m2, n (%) | 0 (0) | 1 (3.6) | 1.000 |
| Pulmonary hypertension (sPAP ≥50 mmHg), n/N (%) | 1/11 (9.1) | 8/21 (38.1) | .187 |
| Pleural effusion, n (%) | 5 (38.5) | 13/27 (48.1) | .564 |
| Symptom to diagnosis, median (range). mo | 7 (1-36) | 16 (3-249) | .009 |
| Male sex, n (%) | 10 (76.9) | 17 (60.7) | .308 |
| Serum VEGF, median (range), pg/mL | 4 624 (187-11 129) | 3 115 (325-8 138) (n = 17) | .133 |
| Polyneuropathy, ONLS score >4, n/N (%) | 6/10 (60.0) (n = 10) | 12/22 (54.5) | .773 |
| Platelets, median (range), ×109/L | 362 (215-731) | 232 (58-594) (n = 20) | .041 |
| Fibrinogen, median (range), g/L | 4.0 (2-7.7) (n = 12) | 3.8 (2.6-5.35) | .414 |
ICVE, ischemic cerebrovascular events; NA, not available.