Baseline clinical characteristics of POEMS patients with and without IS
| Characteristic . | IS group (n = 41) . | Non-IS group (n = 469) . | P . |
|---|---|---|---|
| Age, median (range), y | 54 (24-72) | 47 (21-74) | .003 |
| Male sex, n (%) | 27 (65.9) | 290 (61.8) | .611 |
| Symptom to diagnosis, median (range), mo | 13 (1-249) | 12 (1-274) | .657 |
| Monoclonal gammopathy, n/N (%) | |||
| IgA lambda-type | 20/34 (58.8) | 294/445 (66.1) | .392 |
| Bone marrow ≥10% plasma cells | 1/34 (2.9) | 17/410 (4.1) | 1.000 |
| POEMS features, n/N (%) | |||
| Polyneuropathy: ONLS score >4 | 19/32 (59.4) | 149/386 (38.6) | .021 |
| Skin changes | 38/40 (95.0) | 430/455 (94.5) | 1.000 |
| Organomegaly, n/N (%) | |||
| Hepatomegaly | 11/41 (26.8) | 207/456 (45.4) | .022 |
| Splenomegaly | 27/41 (65.9) | 308/456 (675) | .825 |
| Lymphadenopathy | 26/40 (65.0) | 302/457 (66.1) | .890 |
| Castleman disease | 4/25 (16.0) | 70/354 (19.8) | .842 |
| Endocrinopathy, n/N (%) | |||
| Diabetes mellitus | 6/41 (14.6) | 54/451 (12.0) | .618 |
| Hypothyroidism | 33/39 (84.6) | 314/452 (69.5) | .046 |
| Pleural effusion, n/N (%) | 18/40 (45.0) | 178/443 (40.2) | .552 |
| Papilledema, n/N (%) | 16/24 (66.7) | 207/322 (64.3) | .814 |
| Osteosclerosis, n/N (%) | 22/37 (59.5) | 260/437 (59.5) | .996 |
| Hb, median (range), g/L | 129 (78-178) | 136 (55-194) (n = 460) | .447 |
| Platelets, median (range), ×109/L | 305 (58-731) | 308 (10-1020) (n = 460) | .727 |
| Fibrinogen, median (range), g/L | 3.8 (2-7.7) (n = 35) | 3.5 (1.6-24.5) (n = 381) | .026 |
| Serum albumin, median (range), g/L | 35 (26-44) (n = 38) | 37 (20-66) (n = 357) | .090 |
| eGFR, median (range) | 88 (19-176) | 93 (13-188) (n = 461) | .774 |
| Pulmonary hypertension (sPAP ≥50 mmHg), n/N (%) | 9/32 (28.1) | 69/361(19.1) | .221 |
| Serum VEGF, median (range), pg/mL | 4042 (187-18069) (n = 35) | 4396 (7-23728) (n = 399) | .947 |
| Risk, n/N (%) | |||
| Low (score 0) | 5/40 (12.5) | 116/433 (26.8) | .047 |
| Intermediate (score 1) | 21/40 (52.5) | 195/433 (45.0) | .364 |
| High (score ≥2) | 14/40 (35) | 122/433 (28.2) | .362 |
| Characteristic . | IS group (n = 41) . | Non-IS group (n = 469) . | P . |
|---|---|---|---|
| Age, median (range), y | 54 (24-72) | 47 (21-74) | .003 |
| Male sex, n (%) | 27 (65.9) | 290 (61.8) | .611 |
| Symptom to diagnosis, median (range), mo | 13 (1-249) | 12 (1-274) | .657 |
| Monoclonal gammopathy, n/N (%) | |||
| IgA lambda-type | 20/34 (58.8) | 294/445 (66.1) | .392 |
| Bone marrow ≥10% plasma cells | 1/34 (2.9) | 17/410 (4.1) | 1.000 |
| POEMS features, n/N (%) | |||
| Polyneuropathy: ONLS score >4 | 19/32 (59.4) | 149/386 (38.6) | .021 |
| Skin changes | 38/40 (95.0) | 430/455 (94.5) | 1.000 |
| Organomegaly, n/N (%) | |||
| Hepatomegaly | 11/41 (26.8) | 207/456 (45.4) | .022 |
| Splenomegaly | 27/41 (65.9) | 308/456 (675) | .825 |
| Lymphadenopathy | 26/40 (65.0) | 302/457 (66.1) | .890 |
| Castleman disease | 4/25 (16.0) | 70/354 (19.8) | .842 |
| Endocrinopathy, n/N (%) | |||
| Diabetes mellitus | 6/41 (14.6) | 54/451 (12.0) | .618 |
| Hypothyroidism | 33/39 (84.6) | 314/452 (69.5) | .046 |
| Pleural effusion, n/N (%) | 18/40 (45.0) | 178/443 (40.2) | .552 |
| Papilledema, n/N (%) | 16/24 (66.7) | 207/322 (64.3) | .814 |
| Osteosclerosis, n/N (%) | 22/37 (59.5) | 260/437 (59.5) | .996 |
| Hb, median (range), g/L | 129 (78-178) | 136 (55-194) (n = 460) | .447 |
| Platelets, median (range), ×109/L | 305 (58-731) | 308 (10-1020) (n = 460) | .727 |
| Fibrinogen, median (range), g/L | 3.8 (2-7.7) (n = 35) | 3.5 (1.6-24.5) (n = 381) | .026 |
| Serum albumin, median (range), g/L | 35 (26-44) (n = 38) | 37 (20-66) (n = 357) | .090 |
| eGFR, median (range) | 88 (19-176) | 93 (13-188) (n = 461) | .774 |
| Pulmonary hypertension (sPAP ≥50 mmHg), n/N (%) | 9/32 (28.1) | 69/361(19.1) | .221 |
| Serum VEGF, median (range), pg/mL | 4042 (187-18069) (n = 35) | 4396 (7-23728) (n = 399) | .947 |
| Risk, n/N (%) | |||
| Low (score 0) | 5/40 (12.5) | 116/433 (26.8) | .047 |
| Intermediate (score 1) | 21/40 (52.5) | 195/433 (45.0) | .364 |
| High (score ≥2) | 14/40 (35) | 122/433 (28.2) | .362 |
eGFR: estimated glomerular filtration rate; Hb, hemoglobin; IgA, immunoglobulin A.