Selected univariable and multivariable analysis for OS
| Factors . | HR . | 95% CI . | P . |
|---|---|---|---|
| Univariable analysis for OS | |||
| A-ME Ab HVG | 0.95 | 0.90-1.00 | .053 |
| A-ALL ME HVG | 0.98 | 0.96-0.99 | .024 |
| Class I-Ab ME HVG | 0.98 | 0.95-1.01 | .188 |
| Class I-ALL ME HVG | 0.99 | 0.97-0.99 | .045 |
| DRB345-Ab ME HVG | 1.11 | 1.00-1.23 | .042 |
| DRB345-ALL ME HVG | 1.03 | 1.00-1.05 | .025 |
| DP match/mismatch | |||
| Match | Ref | ||
| Permissive mismatch | 0.71 | 0.47-1.06 | .102 |
| Nonpermissive mismatch GVH | 0.77 | 0.45-1.34 | .368 |
| Nonpermissive mismatch HVG | 0.085 | 0.29-1.08 | .085 |
| Multivariable analysis for OS | |||
| Impact of A-ME HVG | |||
| A-ALL ME HVG (continuous) | 0.97 | 0.95-0.99 | .003 |
| Sex | 1.03 | 0.73-1.45 | .879 |
| Age (continuous) | 1.03 | 1.02-1.05 | <.001 |
| HCT-CI (continuous) | 1.08 | 0.99-1.17 | .064 |
| DRI | |||
| Low | Ref | ||
| Intermediate | 2.08 | 0.92-4.67 | .078 |
| High | 4.04 | 1.81-0.03 | .001 |
| Very high | 6.18 | 2.44-15.61 | <.001 |
| Conditioning regimen intensity | |||
| MAC | Ref | ||
| NMA/RIC | 1.01 | 0.70-1.45 | .950 |
| Hematopoietic cell source | |||
| PB | Ref | ||
| BM | 1.17 | 0.66-2.04 | .598 |
| ABO mismatch | |||
| Match | Ref | ||
| Minor | 0.99 | 0.62-1.57 | .962 |
| Major | 1.74 | 1.09-2.77 | .020 |
| Bidirectional | 1.34 | 0.18-10.06 | .77 |
| Impact of Class I ME HVG | |||
| Class I-All ME HVG (continuous) | 0.99 | 0.97-0.99 | .047 |
| Sex | 1.08 | 0.76-1.51 | .681 |
| Age (continuous) | 1.31 | 1.01-1.05 | <.001 |
| HCT-CI (continuous) | 1.08 | 0.99-1.17 | .054 |
| DRI | |||
| Low | Ref | ||
| Intermediate | 2.24 | 0.99-5.01 | .05 |
| High | 4.10 | 1.83-9.15 | .001 |
| Very high | 6.08 | 2.41-15.32 | <.001 |
| Conditioning regimen intensity | |||
| MAC | Ref | ||
| NMA/RIC | 1.02 | 0.71-1.45 | .927 |
| Hematopoietic cell source | |||
| PB | Ref | ||
| BM | 1.24 | 0.71-2.19 | .445 |
| ABO mismatch | |||
| Match | Ref | ||
| Minor | 1.01 | 0.63-1.60 | .975 |
| Major | 1.71 | 1.07-2.72 | .024 |
| Bidirectional | 1.26 | 0.17-9.43 | .822 |
| Impact of HLA DRB345-ALL ME HVG | |||
| DRB345-All HVG (continuous) | 1.03 | 1.00-1.05 | .038 |
| Factors . | HR . | 95% CI . | P . |
|---|---|---|---|
| Univariable analysis for OS | |||
| A-ME Ab HVG | 0.95 | 0.90-1.00 | .053 |
| A-ALL ME HVG | 0.98 | 0.96-0.99 | .024 |
| Class I-Ab ME HVG | 0.98 | 0.95-1.01 | .188 |
| Class I-ALL ME HVG | 0.99 | 0.97-0.99 | .045 |
| DRB345-Ab ME HVG | 1.11 | 1.00-1.23 | .042 |
| DRB345-ALL ME HVG | 1.03 | 1.00-1.05 | .025 |
| DP match/mismatch | |||
| Match | Ref | ||
| Permissive mismatch | 0.71 | 0.47-1.06 | .102 |
| Nonpermissive mismatch GVH | 0.77 | 0.45-1.34 | .368 |
| Nonpermissive mismatch HVG | 0.085 | 0.29-1.08 | .085 |
| Multivariable analysis for OS | |||
| Impact of A-ME HVG | |||
| A-ALL ME HVG (continuous) | 0.97 | 0.95-0.99 | .003 |
| Sex | 1.03 | 0.73-1.45 | .879 |
| Age (continuous) | 1.03 | 1.02-1.05 | <.001 |
| HCT-CI (continuous) | 1.08 | 0.99-1.17 | .064 |
| DRI | |||
| Low | Ref | ||
| Intermediate | 2.08 | 0.92-4.67 | .078 |
| High | 4.04 | 1.81-0.03 | .001 |
| Very high | 6.18 | 2.44-15.61 | <.001 |
| Conditioning regimen intensity | |||
| MAC | Ref | ||
| NMA/RIC | 1.01 | 0.70-1.45 | .950 |
| Hematopoietic cell source | |||
| PB | Ref | ||
| BM | 1.17 | 0.66-2.04 | .598 |
| ABO mismatch | |||
| Match | Ref | ||
| Minor | 0.99 | 0.62-1.57 | .962 |
| Major | 1.74 | 1.09-2.77 | .020 |
| Bidirectional | 1.34 | 0.18-10.06 | .77 |
| Impact of Class I ME HVG | |||
| Class I-All ME HVG (continuous) | 0.99 | 0.97-0.99 | .047 |
| Sex | 1.08 | 0.76-1.51 | .681 |
| Age (continuous) | 1.31 | 1.01-1.05 | <.001 |
| HCT-CI (continuous) | 1.08 | 0.99-1.17 | .054 |
| DRI | |||
| Low | Ref | ||
| Intermediate | 2.24 | 0.99-5.01 | .05 |
| High | 4.10 | 1.83-9.15 | .001 |
| Very high | 6.08 | 2.41-15.32 | <.001 |
| Conditioning regimen intensity | |||
| MAC | Ref | ||
| NMA/RIC | 1.02 | 0.71-1.45 | .927 |
| Hematopoietic cell source | |||
| PB | Ref | ||
| BM | 1.24 | 0.71-2.19 | .445 |
| ABO mismatch | |||
| Match | Ref | ||
| Minor | 1.01 | 0.63-1.60 | .975 |
| Major | 1.71 | 1.07-2.72 | .024 |
| Bidirectional | 1.26 | 0.17-9.43 | .822 |
| Impact of HLA DRB345-ALL ME HVG | |||
| DRB345-All HVG (continuous) | 1.03 | 1.00-1.05 | .038 |