Overall quality of the included studies assessed by using the GRADE approach
| Quality assessment . | No. of patients, n/N (%) . | Effect . | Quality . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies . | Design . | Risk of bias . | Inconsistency . | Indirectness . | Imprecision . | Other considerations . | HLA-DRB3*0101− . | Control . | Relative OR (95% CI) . | Absolute . | |
| HLA-DRB3*0101−to predict risk of HPA alloimmunization in HPA 1a−women | |||||||||||
| 3 | Observational studies | No serious risk of bias | No serious inconsistency | No serious indirectness | No serious imprecision | None | 8/529 (1.5) | 73/271 (26.9) | 0.03 (0.0-0.44) | 258 fewer per 1000 (from 130 fewer to 269 fewer) | ⊕⊕○○ LOW |
| HLA-DRB3*0101−to predict risk of severe neonatal thrombocytopenia in HPA alloimmunized women | |||||||||||
| 4 | Observational studies | No serious risk of bias | No serious inconsistency | No serious indirectness | No serious imprecision | Strong association* | 2/22 (9.1) | 158/252 (62.7) | 0.08 (0.02-0.37) | 508 fewer per 1000 (from 244 fewer to 594 fewer) | ⊕⊕⊕○ MODERATE |
| HLA-DRB3*01:01−to predict risk of intracranial hemorrhage | |||||||||||
| 2 | Observational studies | Serious† | Serious†,‡ | No serious indirectness | Serious† | None | 0/13 (0) | 22/218 (10.1) | 1.51 (0.16- 14.16) | 44 more per 1000 (from 83 fewer to 513 more) | ⊕○○○ VERY LOW |
| Quality assessment . | No. of patients, n/N (%) . | Effect . | Quality . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies . | Design . | Risk of bias . | Inconsistency . | Indirectness . | Imprecision . | Other considerations . | HLA-DRB3*0101− . | Control . | Relative OR (95% CI) . | Absolute . | |
| HLA-DRB3*0101−to predict risk of HPA alloimmunization in HPA 1a−women | |||||||||||
| 3 | Observational studies | No serious risk of bias | No serious inconsistency | No serious indirectness | No serious imprecision | None | 8/529 (1.5) | 73/271 (26.9) | 0.03 (0.0-0.44) | 258 fewer per 1000 (from 130 fewer to 269 fewer) | ⊕⊕○○ LOW |
| HLA-DRB3*0101−to predict risk of severe neonatal thrombocytopenia in HPA alloimmunized women | |||||||||||
| 4 | Observational studies | No serious risk of bias | No serious inconsistency | No serious indirectness | No serious imprecision | Strong association* | 2/22 (9.1) | 158/252 (62.7) | 0.08 (0.02-0.37) | 508 fewer per 1000 (from 244 fewer to 594 fewer) | ⊕⊕⊕○ MODERATE |
| HLA-DRB3*01:01−to predict risk of intracranial hemorrhage | |||||||||||
| 2 | Observational studies | Serious† | Serious†,‡ | No serious indirectness | Serious† | None | 0/13 (0) | 22/218 (10.1) | 1.51 (0.16- 14.16) | 44 more per 1000 (from 83 fewer to 513 more) | ⊕○○○ VERY LOW |