Table 2.

Characteristics of studies reporting maternal HLA-DRB3*01:01 carrier status and fetal/neonatal outcome in HPA-1a-immunized women

First author, yReferenceCountryYears of data collectionNo. with platelet counts ≥50 × 109/LNo. with platelet counts <50 × 109/L (no. with ICH/death)Comments
No. of HLA-DRB3*01:01+No. of HLA-DRB3*01:01−No. of HLA-DRB3*01:01+No. of HLA-DRB3*01:01−
Prospective studies 
 Williamson, 199835  United Kingdom September 1993-September 1994 23 0 10 (1) 0  
 Maslanka, 200329  Poland — 9 0 3 (1) 0  
 Turner, 200532  United Kingdom August 1999-March 2001 11 7 5 (0) 0 Only fetal platelet counts from 23 of 25 cases. 
 Kjeldsen-Kragh, 201926  Norway December 1995-March 2004 73 11 46 (1) 0 DRB3*01:01 status was unknown for 1 woman who gave birth to a child with ICH, platelet count of 26 × 109/L. HPA-1a-immunized women were offered cesarean section 2-4 wk before term. 
Retrospective studies 
 Loewenthal, 201328  Israel May 2001-January 2011 0 1 18 (0*) 1 (0*) None of the women were treated with IVIG. 
 Peterson, 201330 † United States — 2 4‡ 0 4 (0)§ A selection of women with low-avidity HPA-1a antibodies. 
 Delbos, 201621  France 1987-2012 — — 38 (14) 7 (2) All FNAIT cases had platelet counts <50 × 109/L. No information about other obstetric or neonatal conditions that could cause ICH. 
 Sainio, 201731  Finland 1986-2010 11 0 60* (8*) 0 ICH in 2 infants born to DRB3*01:01− mothers without HPA-1a antibodies. Both cases had associated obstetric problems (severe asphyxia and subependymal hemorrhage associated with vacuum extraction). 
 Wienzek-Lischka, 201734  Germany — 10 1* 89 (21) 1* (0) According to the authors, none of the women were treated with IVIG. 
First author, yReferenceCountryYears of data collectionNo. with platelet counts ≥50 × 109/LNo. with platelet counts <50 × 109/L (no. with ICH/death)Comments
No. of HLA-DRB3*01:01+No. of HLA-DRB3*01:01−No. of HLA-DRB3*01:01+No. of HLA-DRB3*01:01−
Prospective studies 
 Williamson, 199835  United Kingdom September 1993-September 1994 23 0 10 (1) 0  
 Maslanka, 200329  Poland — 9 0 3 (1) 0  
 Turner, 200532  United Kingdom August 1999-March 2001 11 7 5 (0) 0 Only fetal platelet counts from 23 of 25 cases. 
 Kjeldsen-Kragh, 201926  Norway December 1995-March 2004 73 11 46 (1) 0 DRB3*01:01 status was unknown for 1 woman who gave birth to a child with ICH, platelet count of 26 × 109/L. HPA-1a-immunized women were offered cesarean section 2-4 wk before term. 
Retrospective studies 
 Loewenthal, 201328  Israel May 2001-January 2011 0 1 18 (0*) 1 (0*) None of the women were treated with IVIG. 
 Peterson, 201330 † United States — 2 4‡ 0 4 (0)§ A selection of women with low-avidity HPA-1a antibodies. 
 Delbos, 201621  France 1987-2012 — — 38 (14) 7 (2) All FNAIT cases had platelet counts <50 × 109/L. No information about other obstetric or neonatal conditions that could cause ICH. 
 Sainio, 201731  Finland 1986-2010 11 0 60* (8*) 0 ICH in 2 infants born to DRB3*01:01− mothers without HPA-1a antibodies. Both cases had associated obstetric problems (severe asphyxia and subependymal hemorrhage associated with vacuum extraction). 
 Wienzek-Lischka, 201734  Germany — 10 1* 89 (21) 1* (0) According to the authors, none of the women were treated with IVIG. 
*

Numbers obtained from the authors.

†

This study contained 2 populations with different risk profiles; see text.

‡

Three of these were infants born of women whose sister previously had had a child with FNAIT. Two women received IVIG treatment during pregnancy.

§

Data from 2 severely thrombocytopenic children were also included in the analysis, despite HPA-1a typing lacking for these 2 children. According to the authors, the child’s platelet type in case 5 was HPA-1a/b and not HPA-1a/a as indicated in the paper.30 

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