Table 3. Association of most significant... | American Society of Hematology

Table 3.

Association of most significant GWAS variants per LD block with NRM and RM

Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	Discovery results		Replication results
Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	P	HR (95% CI)	P	HR (95% CI)	Power, %‡
6	MIR548A1HG	rs9350085	C/T	NRM	Recipient	Allelic	0.37	7.7E−07	1.29 (1.2-1.4)	.65	0.97 (0.9-1.1)	100
6	LOC105377999	rs9492413	C/T	NRM	Donor	Allelic	0.19	9.8E−07	1.35 (1.2-1.5)	.86	0.99 (0.9-1.1)	100
12	none	rs11451044	CA/C	NRM	Donor	Allelic	0.45	5.8E−07	1.28 (1.2-1.4)	1.00	1.00 (0.9-1.1)	100
4	GBA3	rs114484584	C/T	RM	Recipient	Allelic	0.02	2.4E−07	2.46 (1.8-3.3)	.23	0.63 (0.3-1.4)	16
11	CCDC81	rs148290359	C/T	RM	Recipient	Allelic	0.02	2.3E−07	0.14 (0.04-0.4)	.46	1.23 (0.7-2.1)	33
7	none	rs117446118	G/A	RM	Donor	Allelic	0.02	8.1E−07	2.91 (2.0-4.2)	.10	0.60 (0.3-1.2)	22
9	ADAMTSL1	rs60125430	C/T	RM	Donor	Allelic	0.09	4.6E−08	1.74 (1.4-2.1)	.37	1.15 (0.9-1.5)	77

Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	Discovery results		Replication results
Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	P	HR (95% CI)	P	HR (95% CI)	Power, %‡
6	MIR548A1HG	rs9350085	C/T	NRM	Recipient	Allelic	0.37	7.7E−07	1.29 (1.2-1.4)	.65	0.97 (0.9-1.1)	100
6	LOC105377999	rs9492413	C/T	NRM	Donor	Allelic	0.19	9.8E−07	1.35 (1.2-1.5)	.86	0.99 (0.9-1.1)	100
12	none	rs11451044	CA/C	NRM	Donor	Allelic	0.45	5.8E−07	1.28 (1.2-1.4)	1.00	1.00 (0.9-1.1)	100
4	GBA3	rs114484584	C/T	RM	Recipient	Allelic	0.02	2.4E−07	2.46 (1.8-3.3)	.23	0.63 (0.3-1.4)	16
11	CCDC81	rs148290359	C/T	RM	Recipient	Allelic	0.02	2.3E−07	0.14 (0.04-0.4)	.46	1.23 (0.7-2.1)	33
7	none	rs117446118	G/A	RM	Donor	Allelic	0.02	8.1E−07	2.91 (2.0-4.2)	.10	0.60 (0.3-1.2)	22
9	ADAMTSL1	rs60125430	C/T	RM	Donor	Allelic	0.09	4.6E−08	1.74 (1.4-2.1)	.37	1.15 (0.9-1.5)	77

Plus strand major/minor alleles.

†

MAF in the samples used for the test.

‡

Post hoc power estimates to detect an HR ≥1.5 or ≤0.67 at a 2-sided significance level of .05 were based on the estimated standard error of the log HR in the replication cohort.

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