Table 2. Association of candidate... | American Society of Hematology

Table 2.

Association of candidate variants with NRM and RM

Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	Discovery results		Replication results
Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	P	HR (95% CI)	P	HR (95% CI)	Power, %‡
9	CD274	rs10975123	C/T	NRM	Recipient	Recessive	0.18	.00004	2.05 (1.5-2.8)	.46	0.84 (0.5-1.4)	39
9	CD274	rs10975123	C/T	NRM	Recipient	Allelic	0.18	.0008	1.24 (1.1-1.4)	.99	1.00 (0.9-1.2)	100
6	HLA-DOA	rs429916	C/A	NRM	Recipient	Recessive	0.07	.004	2.91 (1.6-5.4)	.19	0.34 (0.05-2.4)	6
6	MICA	rs1051792	G/A	NRM	Donor	Allelic	0.27	.002	0.84 (0.8-0.9)	.02	0.85 (0.7-1.0)	100
5	IL12B	rs3212227	T/G	NRM	Donor	Recessive	0.21	.005	0.56 (0.4-0.9)	.39	1.21 (0.8-1.8)	48
3	CCR5	rs1800023	A/G	RM	Donor	Dominant	0.36	.002	1.29 (1.1-1.5)	.14	1.16 (1.0-1.4)	100

Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	Discovery results		Replication results
Chr	Gene	SNP	Alleles*	End point	Genome	Model	MAF†	P	HR (95% CI)	P	HR (95% CI)	Power, %‡
9	CD274	rs10975123	C/T	NRM	Recipient	Recessive	0.18	.00004	2.05 (1.5-2.8)	.46	0.84 (0.5-1.4)	39
9	CD274	rs10975123	C/T	NRM	Recipient	Allelic	0.18	.0008	1.24 (1.1-1.4)	.99	1.00 (0.9-1.2)	100
6	HLA-DOA	rs429916	C/A	NRM	Recipient	Recessive	0.07	.004	2.91 (1.6-5.4)	.19	0.34 (0.05-2.4)	6
6	MICA	rs1051792	G/A	NRM	Donor	Allelic	0.27	.002	0.84 (0.8-0.9)	.02	0.85 (0.7-1.0)	100
5	IL12B	rs3212227	T/G	NRM	Donor	Recessive	0.21	.005	0.56 (0.4-0.9)	.39	1.21 (0.8-1.8)	48
3	CCR5	rs1800023	A/G	RM	Donor	Dominant	0.36	.002	1.29 (1.1-1.5)	.14	1.16 (1.0-1.4)	100

Chr, chromosome; CI, confidence interval; HR, hazard ratio.

Plus strand major/minor alleles.

†

MAF in the samples used for the test.

‡

Post hoc power estimates to detect an HR ≥1.5 or ≤0.67 at a 2-sided significance level of .05 were based on the estimated standard error of the log HR in the replication cohort.

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