Table 1. Demographic and outcome data... | American Society of Hematology

Table 1.

Demographic and outcome data

UPN	Diagnosis	Age at HSCT, y	Conditioning regimen	GVHD prevention	Max sC5b-9, ng/mL	Ecu start to first VST, d	No. of Ecu doses	Source of VST product	Treated virus	Post-HSCT day at first VST	Viral load at first VST	ALC at time of first VST, cells/µL	Total no. of VST infusions while blocked*	Best response: CR, PR, NR	Current status
27	SCID	4.23	RIC	T-CD	>1890	0	6	DD	ADV	64	ADV: 392 534 700	80	1	ADV-NR	Deceased, adenoviremia
54	DBA	11.67	MAC	CI	315	−20	16	DD	ADV, CMV	36	ADV: 241 787 CMV: <500	1640	1	ADV-CR CMV-CR	Alive
34	ZAP-70 deficiency	25.91	RIC	CI	1641	−5	8	DD	BKV	224	BKV: 2 074 700	1460	1	BKV-PR	Deceased, multiorgan failure
63	β-thalassemia	7.65	MAC	CI	195	10	12	DD	CMV	31	CMV: 1 401	40	2	CMV-CR	Alive
94	ALL	18.96	MAC	CI	469	−28	26	DD	ADV, BKV, EBV	94	ADV: 5 184 BKV: 1 440 951 EBV: 256 252	120	3	ADV-CR BKV-CR EBV-CR	Alive
110	HLH	16.27	RIC	CI	453	−44	9	DD then TP	BKV	30	BKV: 14 686	210	3	BKV-CR	Alive
107	LRBA deficiency	13.48	RIC	CI	263	−68	29	DD	ADV	86	ADV: 2 681	130	2	ADV-CR	Alive
114	Porphyria	18.13	RIC	T-CD	513	−23	13	DD	BKV, EBV	36	BKV: 4 980 EBV: 2 730	380	2	BKV-CR EBV-CR	Alive
137	AML	4.26	MAC	CI	284	−25	35	DD	CMV, EBV	62	CMV: 3 561 EBV: 21 627	300	2	CMV-PR EBV-PR	Alive
215	CGD	15.19	MAC	CI	667	−31	23	DD	CMV	87	CMV: 12 744	30	2	CMV-CR	Alive
233	LPD	15.47	RIC	T-CD	331	6	16	DD	ADV, BKV	29	ADV: 14 310 BKV: 28 168	330	1	ADV-CR BKV-NR	Alive
45	CGD	11.55	MAC	T-CD	112	−14	32	TP	BKV	133	BKV: 310 022	130	6	BKV-CR	Alive
97	Disseminated adenovirus	18.68†	N/A	N/A	>1670	6	4	TP	ADV	N/A	ADV: 51 571 597	140	1	ADV-CR	Deceased, multiorgan failure

UPN	Diagnosis	Age at HSCT, y	Conditioning regimen	GVHD prevention	Max sC5b-9, ng/mL	Ecu start to first VST, d	No. of Ecu doses	Source of VST product	Treated virus	Post-HSCT day at first VST	Viral load at first VST	ALC at time of first VST, cells/µL	Total no. of VST infusions while blocked*	Best response: CR, PR, NR	Current status
27	SCID	4.23	RIC	T-CD	>1890	0	6	DD	ADV	64	ADV: 392 534 700	80	1	ADV-NR	Deceased, adenoviremia
54	DBA	11.67	MAC	CI	315	−20	16	DD	ADV, CMV	36	ADV: 241 787 CMV: <500	1640	1	ADV-CR CMV-CR	Alive
34	ZAP-70 deficiency	25.91	RIC	CI	1641	−5	8	DD	BKV	224	BKV: 2 074 700	1460	1	BKV-PR	Deceased, multiorgan failure
63	β-thalassemia	7.65	MAC	CI	195	10	12	DD	CMV	31	CMV: 1 401	40	2	CMV-CR	Alive
94	ALL	18.96	MAC	CI	469	−28	26	DD	ADV, BKV, EBV	94	ADV: 5 184 BKV: 1 440 951 EBV: 256 252	120	3	ADV-CR BKV-CR EBV-CR	Alive
110	HLH	16.27	RIC	CI	453	−44	9	DD then TP	BKV	30	BKV: 14 686	210	3	BKV-CR	Alive
107	LRBA deficiency	13.48	RIC	CI	263	−68	29	DD	ADV	86	ADV: 2 681	130	2	ADV-CR	Alive
114	Porphyria	18.13	RIC	T-CD	513	−23	13	DD	BKV, EBV	36	BKV: 4 980 EBV: 2 730	380	2	BKV-CR EBV-CR	Alive
137	AML	4.26	MAC	CI	284	−25	35	DD	CMV, EBV	62	CMV: 3 561 EBV: 21 627	300	2	CMV-PR EBV-PR	Alive
215	CGD	15.19	MAC	CI	667	−31	23	DD	CMV	87	CMV: 12 744	30	2	CMV-CR	Alive
233	LPD	15.47	RIC	T-CD	331	6	16	DD	ADV, BKV	29	ADV: 14 310 BKV: 28 168	330	1	ADV-CR BKV-NR	Alive
45	CGD	11.55	MAC	T-CD	112	−14	32	TP	BKV	133	BKV: 310 022	130	6	BKV-CR	Alive
97	Disseminated adenovirus	18.68†	N/A	N/A	>1670	6	4	TP	ADV	N/A	ADV: 51 571 597	140	1	ADV-CR	Deceased, multiorgan failure

ADV, adenovirus; ALC, absolute lymphocyte count; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; BKV, BK virus; CGD, chronic granulomatous disease; CI, calcineurin inhibitor–containing regimen; DBA, Diamond-Blackfan anemia; DD, donor derived; Ecu, eculizumab; GVHD, graft-vs-host disease; HLH, hemophagocytic lymphohistiocytosis; HSCT, hematopoietic stem cell transplant; LPD, lymphoproliferative disorder; MAC, myeloablative conditioning; Max, maximum; N/A, not applicable; NR, no response; RIC, reduced-intensity conditioning; SCID, severe combined immunodeficiency; T-CD, T-cell depletion; TP, third party; UPN, unique patient number.

Number of discrete infusions. Some infusions treated >1 viral infection.

†

Patient did not undergo HSCT; age listed is at time of VST infusion.

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