Predicators of OS and PFS
| Outcome and variable . | Univariate analysis OR (95% CI) . | Multivariate analysis OR (95% CI) . | Multivariate analysis P . |
|---|---|---|---|
| Cohort 1 | |||
| OS | |||
| MTV manual, high vs low | 0.25 (0.10-0.66) | 0.20 (0.07-0.57) | .002 |
| Bridging therapy, yes vs no | 1.00 (0.38-2.58) | 1.02 (0.39-2.69) | .95 |
| LDH before conditioning >2×ULN vs <2×ULN | 1.45 (0.56-3.73) | 0.60 (0.21-1.68) | .33 |
| PFS | |||
| MTV manual, high vs low | 0.40 (0.18-0.89) | 0.30 (0.12-0.72) | .007 |
| Bridging therapy, yes vs no | 0.72 (0.30-1.70) | 0.78 (0.32-1.87) | .58 |
| LDH before conditioning >2×ULN vs <2×ULN | 1.04 (0.42-2.60) | 0.51 (0.18-1.43) | .20 |
| Cohort 2 | |||
| OS | |||
| MTV manual, high vs low | 0.14 (0.05-0.42) | 0.18 (0.04-0.69) | .01 |
| Bridging therapy, yes vs no | 2.99 (0.85-10.43) | 0.77 (0.15-3.84) | .75 |
| LDH before conditioning >2×ULN vs <2×ULN | 5.86 (2.18-15.71) | 3.17 (1.07-9.40) | .03 |
| PFS | |||
| MTV manual, high vs low | 0.29 (0.12-0.69) | 0.34 (0.12-0.96) | .04 |
| Bridging therapy, yes vs no | 2.00 (0.78-5.14) | 0.93 (0.29-2.93) | .93 |
| LDH before conditioning >2×ULN vs <2×ULN | 4.22 (1.59-11.22) | 3.18 (1.09-9.31) | .03 |
| Outcome and variable . | Univariate analysis OR (95% CI) . | Multivariate analysis OR (95% CI) . | Multivariate analysis P . |
|---|---|---|---|
| Cohort 1 | |||
| OS | |||
| MTV manual, high vs low | 0.25 (0.10-0.66) | 0.20 (0.07-0.57) | .002 |
| Bridging therapy, yes vs no | 1.00 (0.38-2.58) | 1.02 (0.39-2.69) | .95 |
| LDH before conditioning >2×ULN vs <2×ULN | 1.45 (0.56-3.73) | 0.60 (0.21-1.68) | .33 |
| PFS | |||
| MTV manual, high vs low | 0.40 (0.18-0.89) | 0.30 (0.12-0.72) | .007 |
| Bridging therapy, yes vs no | 0.72 (0.30-1.70) | 0.78 (0.32-1.87) | .58 |
| LDH before conditioning >2×ULN vs <2×ULN | 1.04 (0.42-2.60) | 0.51 (0.18-1.43) | .20 |
| Cohort 2 | |||
| OS | |||
| MTV manual, high vs low | 0.14 (0.05-0.42) | 0.18 (0.04-0.69) | .01 |
| Bridging therapy, yes vs no | 2.99 (0.85-10.43) | 0.77 (0.15-3.84) | .75 |
| LDH before conditioning >2×ULN vs <2×ULN | 5.86 (2.18-15.71) | 3.17 (1.07-9.40) | .03 |
| PFS | |||
| MTV manual, high vs low | 0.29 (0.12-0.69) | 0.34 (0.12-0.96) | .04 |
| Bridging therapy, yes vs no | 2.00 (0.78-5.14) | 0.93 (0.29-2.93) | .93 |
| LDH before conditioning >2×ULN vs <2×ULN | 4.22 (1.59-11.22) | 3.18 (1.09-9.31) | .03 |