Univariable and multivariable analysis
| . | EFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|
| . | Univariable HR . | P . | Multivariable HR . | P . | Univariable HR . | P . | Multivariable HR . | P . |
| Age >60 y | 1.5 (0.8-2.9) | .2 | 1.7 (0.8-3.6) | .2 | ||||
| ABC subtype | 1.3 (0.7-2.4) | .5 | 1.4 (0.7-2.9) | .4 | ||||
| Ki67 ≥90% | 0.9 (0.5-1.8) | .8 | 1.2 (0.6-2.4) | .6 | ||||
| ECOG score >1 | 4.4 (2.4-8.3) | <.001 | 2.2 (1.1-4.5) | .032 | 6.1 (3.0-12.5) | <.001 | 3.3 (1.3-7.9) | .006 |
| Stages III-IV | 6.6 (2.0-21) | <.001 | 1.9 (0.5-7.3) | .3 | 4.8 (1.5-15.8) | .001 | 1.3 (0.3-5.5) | .7 |
| B symptoms | 2.4 (1.2-4.9) | .026 | 1.7 (0.7-3.7) | .2 | 3.0 (1.4-6.4) | .008 | 1.9 (0.8-4.5) | .2 |
| Bulk (≥10 cm) | 0.7 (0.3-1.5) | .3 | 0.5 (0.2-1.2) | .11 | ||||
| Elevated LDH | 5.9 (2.3-15) | <.001 | 2.5 (0.85-7.3) | .08 | 4.3 (1.6-11.1) | <.001 | 1.6 (0.5-5.2) | .4 |
| Extranodal sites >1 | 7.6 (2.3-25) | <.001 | 3.0 (0.8-11) | .2 | 8.1 (1.9-34.7) | .001 | 3.7 (0.77-17.9) | .11 |
| FISH | ||||||||
| WT | Ref | .063 | .2 | Ref | .4 | .5 | ||
| EC | 0.8 (0.3-1.8) | 0.8 (0.4-2.0) | 0.9 (0.4-2.3) | 1.1 (0.4-2.8) | ||||
| DHL | 1.8 (0.9-3.8) | 1.7 (0.8-3.9) | 1.5 (0.7-3.6) | 1.8 (0.7-4.5) | ||||
| . | EFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|
| . | Univariable HR . | P . | Multivariable HR . | P . | Univariable HR . | P . | Multivariable HR . | P . |
| Age >60 y | 1.5 (0.8-2.9) | .2 | 1.7 (0.8-3.6) | .2 | ||||
| ABC subtype | 1.3 (0.7-2.4) | .5 | 1.4 (0.7-2.9) | .4 | ||||
| Ki67 ≥90% | 0.9 (0.5-1.8) | .8 | 1.2 (0.6-2.4) | .6 | ||||
| ECOG score >1 | 4.4 (2.4-8.3) | <.001 | 2.2 (1.1-4.5) | .032 | 6.1 (3.0-12.5) | <.001 | 3.3 (1.3-7.9) | .006 |
| Stages III-IV | 6.6 (2.0-21) | <.001 | 1.9 (0.5-7.3) | .3 | 4.8 (1.5-15.8) | .001 | 1.3 (0.3-5.5) | .7 |
| B symptoms | 2.4 (1.2-4.9) | .026 | 1.7 (0.7-3.7) | .2 | 3.0 (1.4-6.4) | .008 | 1.9 (0.8-4.5) | .2 |
| Bulk (≥10 cm) | 0.7 (0.3-1.5) | .3 | 0.5 (0.2-1.2) | .11 | ||||
| Elevated LDH | 5.9 (2.3-15) | <.001 | 2.5 (0.85-7.3) | .08 | 4.3 (1.6-11.1) | <.001 | 1.6 (0.5-5.2) | .4 |
| Extranodal sites >1 | 7.6 (2.3-25) | <.001 | 3.0 (0.8-11) | .2 | 8.1 (1.9-34.7) | .001 | 3.7 (0.77-17.9) | .11 |
| FISH | ||||||||
| WT | Ref | .063 | .2 | Ref | .4 | .5 | ||
| EC | 0.8 (0.3-1.8) | 0.8 (0.4-2.0) | 0.9 (0.4-2.3) | 1.1 (0.4-2.8) | ||||
| DHL | 1.8 (0.9-3.8) | 1.7 (0.8-3.9) | 1.5 (0.7-3.6) | 1.8 (0.7-4.5) | ||||
Data are HR (95% CI). Bold indicates statistically significant results.
ABC, activated B cell; ECOG, Eastern cooperative oncology group; HR, hazard ratio; Ref, reference.