Subtypes, mutations, and prognostic effects in T-LBL and T-ALL
| Subtype . | T-ALL . | T-LBL . | ||
|---|---|---|---|---|
| Aberrations/rearrangements . | Outcome . | Aberrations/rearrangements . | Outcome . | |
| Immature | MEF2C, HOXA-activating fusions | Poor for HOXA+- ETP-ALL | HOXA-activating fusions, TAL1, LMO2, MYC, NOTCH1, TCL1A | Unknown |
| TLX | TLX3, HOXA-activating fusions | Unknown | ||
| Proliferative | TLX1, NKX2-1, NKX2-2 | Favorable | ||
| TALLMO | TAL1, TAL2, LYL1, LMO1, LMO2, LMO3, MYC | Unknown | ||
| Aberration | Incidence | Prognostic effect | Incidence | Prognostic effect |
| NOTCH1mut | >50%40 | Strong trend toward favorable | 55%43 | Favorable |
| FBXW7mut | 11%-31%40 | No effect | 13%43 | No effect |
| NOTCH1mut FBXW7mut | Unknown | Trend toward favorable41 | 15%43 | Favorable |
| LOH6qpos | 13%49 | No effect | 19%48 | Unfavorable |
| PTENdel/mut | 13%67,72 | Unfavorable | 15%69,72 | Unfavorable |
| PTENdel/mut NOTCH1mut | — | Favorable78 | — | Favorable69 |
| PTENdel/mut LOH6qpos | — | Unknown | — | Unfavorable69 |
| PHF6mut | No effect57 | Favorable | ||
| Pediatric | 16%55 | — | ||
| Adult | 39%55 | 25%34 | ||
| IL7Rmut | ||||
| Pediatric | 35%64 | Unfavorable65,66 | ||
| Adult | 26%34 | No effect | ||
| NRAS/KRASmut | ||||
| Pediatric | 10%69 | No effect | ||
| Adult | 10%67 | Unfavorable | ||
| Subtype . | T-ALL . | T-LBL . | ||
|---|---|---|---|---|
| Aberrations/rearrangements . | Outcome . | Aberrations/rearrangements . | Outcome . | |
| Immature | MEF2C, HOXA-activating fusions | Poor for HOXA+- ETP-ALL | HOXA-activating fusions, TAL1, LMO2, MYC, NOTCH1, TCL1A | Unknown |
| TLX | TLX3, HOXA-activating fusions | Unknown | ||
| Proliferative | TLX1, NKX2-1, NKX2-2 | Favorable | ||
| TALLMO | TAL1, TAL2, LYL1, LMO1, LMO2, LMO3, MYC | Unknown | ||
| Aberration | Incidence | Prognostic effect | Incidence | Prognostic effect |
| NOTCH1mut | >50%40 | Strong trend toward favorable | 55%43 | Favorable |
| FBXW7mut | 11%-31%40 | No effect | 13%43 | No effect |
| NOTCH1mut FBXW7mut | Unknown | Trend toward favorable41 | 15%43 | Favorable |
| LOH6qpos | 13%49 | No effect | 19%48 | Unfavorable |
| PTENdel/mut | 13%67,72 | Unfavorable | 15%69,72 | Unfavorable |
| PTENdel/mut NOTCH1mut | — | Favorable78 | — | Favorable69 |
| PTENdel/mut LOH6qpos | — | Unknown | — | Unfavorable69 |
| PHF6mut | No effect57 | Favorable | ||
| Pediatric | 16%55 | — | ||
| Adult | 39%55 | 25%34 | ||
| IL7Rmut | ||||
| Pediatric | 35%64 | Unfavorable65,66 | ||
| Adult | 26%34 | No effect | ||
| NRAS/KRASmut | ||||
| Pediatric | 10%69 | No effect | ||
| Adult | 10%67 | Unfavorable | ||