Summary of PUSH baseline covariates shown as number (%) or median (IQR)
| Covariate . | 1-parent . | 2-parent . | P . | ||
|---|---|---|---|---|---|
| Median (IQR) . | n . | Median (IQR) . | n . | ||
| Age, y | 12 (7-16) | 213 | 14 (7-18) | 142 | .049 |
| Female sex, n (%) | 105 (49) | 213 | 66 (46) | 142 | .7 |
| BMI, kg/m2 | 17 (15-21) | 213 | 18 (16-21) | 140 | .033 |
| Systolic blood pressure, mm Hg | 112 (103-119) | 204 | 110 (106-119) | 139 | .7 |
| Diastolic blood pressure, mm Hg | 63 (57-69) | 204 | 64 (59-70) | 139 | .19 |
| Lactate dehydrogenase, U/L | 476 (351-597) | 186 | 437 (324-581) | 124 | .097 |
| Aspartate aminotransferase, U/L | 45 (34-54) | 204 | 45 (32-60) | 137 | .9 |
| Total bilirubin, mg/dL | 2.4 (1.7-3.5) | 203 | 2.7 (2.0-4.9) | 137 | .0089 |
| Reticulocytes, % | 8.8 (6.2-12) | 197 | 9.5 (6.0-13) | 135 | .6 |
| Hemoglobin, g/dL | 8.5 (7.6-9.6) | 206 | 8.8 (7.9-9.8) | 135 | .2 |
| Hematocrit, % | 25 (22-28) | 204 | 25 (22-28) | 136 | .16 |
| Red blood cells, ×106/µL | 2.8 (2.5-3.2) | 205 | 2.8 (2.5-3.3) | 136 | .6 |
| White blood cells, ×103/µL | 11 (8.3-13) | 205 | 11 (8.9-14) | 136 | .10 |
| Platelets, ×103/µL | 401 (336-492) | 205 | 402 (305-507) | 136 | .8 |
| Hydroxyurea, n (%) | 94 (44) | 213 | 61 (43) | 142 | .9 |
| Chronic transfusion, n (%) | 38 (18) | 212 | 27 (19) | 142 | .9 |
| No. of transfusions lifetime | 2 (2-3) | 210 | 2 (2-4) | 142 | .045 |
| No. of hospitalizations in the past 6 mo | 0 (0-1) | 212 | 1 (0-1) | 142 | .12 |
| Covariate . | 1-parent . | 2-parent . | P . | ||
|---|---|---|---|---|---|
| Median (IQR) . | n . | Median (IQR) . | n . | ||
| Age, y | 12 (7-16) | 213 | 14 (7-18) | 142 | .049 |
| Female sex, n (%) | 105 (49) | 213 | 66 (46) | 142 | .7 |
| BMI, kg/m2 | 17 (15-21) | 213 | 18 (16-21) | 140 | .033 |
| Systolic blood pressure, mm Hg | 112 (103-119) | 204 | 110 (106-119) | 139 | .7 |
| Diastolic blood pressure, mm Hg | 63 (57-69) | 204 | 64 (59-70) | 139 | .19 |
| Lactate dehydrogenase, U/L | 476 (351-597) | 186 | 437 (324-581) | 124 | .097 |
| Aspartate aminotransferase, U/L | 45 (34-54) | 204 | 45 (32-60) | 137 | .9 |
| Total bilirubin, mg/dL | 2.4 (1.7-3.5) | 203 | 2.7 (2.0-4.9) | 137 | .0089 |
| Reticulocytes, % | 8.8 (6.2-12) | 197 | 9.5 (6.0-13) | 135 | .6 |
| Hemoglobin, g/dL | 8.5 (7.6-9.6) | 206 | 8.8 (7.9-9.8) | 135 | .2 |
| Hematocrit, % | 25 (22-28) | 204 | 25 (22-28) | 136 | .16 |
| Red blood cells, ×106/µL | 2.8 (2.5-3.2) | 205 | 2.8 (2.5-3.3) | 136 | .6 |
| White blood cells, ×103/µL | 11 (8.3-13) | 205 | 11 (8.9-14) | 136 | .10 |
| Platelets, ×103/µL | 401 (336-492) | 205 | 402 (305-507) | 136 | .8 |
| Hydroxyurea, n (%) | 94 (44) | 213 | 61 (43) | 142 | .9 |
| Chronic transfusion, n (%) | 38 (18) | 212 | 27 (19) | 142 | .9 |
| No. of transfusions lifetime | 2 (2-3) | 210 | 2 (2-4) | 142 | .045 |
| No. of hospitalizations in the past 6 mo | 0 (0-1) | 212 | 1 (0-1) | 142 | .12 |
Bold entries are significant with P < .05. P values are based on Fisher’s exact test or Wilcoxon’s rank sum test for categorical or continuous variable, respectively. Missing values in the data are because of missed records and missed or failed laboratory assays.
IQR, interquartile range; PUSH, Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease.