Table 2.

Bleeding events

Patient sexAge, yCritically illType(s) of bleedingPlatelet count at bleed(s), ×109/LAnticoagulation at bleed(s)WHO grade(s)Comments
Male 67 Yes GI 47 Therapeutic (UFH) On anticoagulation for pulmonary embolus and clotting of CVVH circuit at time of bleed 
Male 59 No Hemoptysis 134 None Recurrent 
Male 62 Yes GI 242 Prophylactic (UFH)  
Male 37 No Hemoptysis 426 Prophylactic (enoxaparin)  
Male 68 Yes Oral mucosa bleeding 227 Prophylactic (enoxaparin) Recurrent 
Male 56 No Epistaxis 208 Prophylactic (enoxaparin) Recurrent 
Male 49 Yes Epistaxis; bleeding from multiple cannulation sites 115; 184 Prophylactic (enoxaparin) for both events 3; 1 Epistaxis recurrent and required otolaryngology consult and prolonged packing; DIC 
Male 59 Yes Bleeding from multiple cannulation sites; intracranial hemorrhage 155; 257 Therapeutic (UFH) for both events 1; 4 Fatal intracranial hemorrhage; DIC 
Female 65 Yes Internal bleeding 177 Prophylactic (UFH) Recurrent; strong clinical suspicion of internal bleeding due to rapidly declining hemoglobin (>2 g/dL drop each time requiring transfusion) with no other cause (unable to scan) 
Male 69 Yes Oropharyngeal bleeding from tongue mass 414 Prophylactic (UFH) Recurrent; required consult from otolaryngology and prolonged oral packing. Tongue mass was a suspected, but not a known, cancer. 
Male 34 No Hemoptysis 142 Therapeutic (UFH)  
Female 44 Yes Pulmonary hemorrhage 47 Therapeutic (UFH) Anticoagulated with impella in place; DIC 
Male 79 Yes GI 297 Therapeutic (UFH)  
Male 67 No Spontaneous right kidney hematoma 157 Prophylactic (enoxaparin)  
Male 59 Yes GI None Developed COVID-19–associated immune thrombocytopenia 3 d prior to bleed 
Male 83 No GI 46 Warfarin INR: 6.5 at time of bleed 
Male 84 No GI 66 Warfarin INR: 1.5 at time of bleed 
Male 70 No GI 262 Clopidogrel  
Male 65 Yes GI 59 Prophylactic (enoxaparin)  
Patient sexAge, yCritically illType(s) of bleedingPlatelet count at bleed(s), ×109/LAnticoagulation at bleed(s)WHO grade(s)Comments
Male 67 Yes GI 47 Therapeutic (UFH) On anticoagulation for pulmonary embolus and clotting of CVVH circuit at time of bleed 
Male 59 No Hemoptysis 134 None Recurrent 
Male 62 Yes GI 242 Prophylactic (UFH)  
Male 37 No Hemoptysis 426 Prophylactic (enoxaparin)  
Male 68 Yes Oral mucosa bleeding 227 Prophylactic (enoxaparin) Recurrent 
Male 56 No Epistaxis 208 Prophylactic (enoxaparin) Recurrent 
Male 49 Yes Epistaxis; bleeding from multiple cannulation sites 115; 184 Prophylactic (enoxaparin) for both events 3; 1 Epistaxis recurrent and required otolaryngology consult and prolonged packing; DIC 
Male 59 Yes Bleeding from multiple cannulation sites; intracranial hemorrhage 155; 257 Therapeutic (UFH) for both events 1; 4 Fatal intracranial hemorrhage; DIC 
Female 65 Yes Internal bleeding 177 Prophylactic (UFH) Recurrent; strong clinical suspicion of internal bleeding due to rapidly declining hemoglobin (>2 g/dL drop each time requiring transfusion) with no other cause (unable to scan) 
Male 69 Yes Oropharyngeal bleeding from tongue mass 414 Prophylactic (UFH) Recurrent; required consult from otolaryngology and prolonged oral packing. Tongue mass was a suspected, but not a known, cancer. 
Male 34 No Hemoptysis 142 Therapeutic (UFH)  
Female 44 Yes Pulmonary hemorrhage 47 Therapeutic (UFH) Anticoagulated with impella in place; DIC 
Male 79 Yes GI 297 Therapeutic (UFH)  
Male 67 No Spontaneous right kidney hematoma 157 Prophylactic (enoxaparin)  
Male 59 Yes GI None Developed COVID-19–associated immune thrombocytopenia 3 d prior to bleed 
Male 83 No GI 46 Warfarin INR: 6.5 at time of bleed 
Male 84 No GI 66 Warfarin INR: 1.5 at time of bleed 
Male 70 No GI 262 Clopidogrel  
Male 65 Yes GI 59 Prophylactic (enoxaparin)  

GI, gastrointestinal.

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