Factors influencing the bleeding rate in weeks 1 to 12
| Parameter . | Univariate IRR (95% CI) . | P . | Multivariate IRR (95% CI) . | P . |
|---|---|---|---|---|
| FVIII activity category | ||||
| <1% | 7.4 (3.1-18) | <.0001 | 7.1 (3.1-16) | <.0001 |
| 1 to <5% | 7.5 (3.3-17) | <.0001 | 8.2 (3.7-18) | <.0001 |
| 5 to <20% | 6.4 (2.9-14) | <.0001 | 6.5 (3.0-14) | <.0001 |
| 20 to <50% | 4.4 (2.0-9.6) | .0002 | 4.6 (2.1-10) | <.0001 |
| ≥50% | 1 | 1 | ||
| Age (per year) | 1.01 (0.99-1.02) | .537 | ||
| Body weight (per kg) | 1.02 (1.00-1.03) | .054 | ||
| Female sex | 0.90 (0.55-1.5) | .682 | ||
| WHO performance status | ||||
| 0 (best) | 0.32 (0.12-0.89) | .029 | 0.23 (0.09-0.62) | .004 |
| 1 | 0.86 (0.42-1.8) | .691 | 0.61 (0.31-1.2) | .151 |
| 2 | 0.91 (0.42-1.9) | .805 | 0.63 (0.31-1.3) | .211 |
| 3 | 1.3 (0.65-2.8) | .426 | 0.81 (0.41-1.6) | .552 |
| 4 or 5 (worst) | 1 | 1 | ||
| Underlying disorders | ||||
| Malignancy | 0.47 (0.19-1.1) | .095 | ||
| Autoimmunity | 1.0 (0.55-1.8) | .986 | ||
| Pregnancy | 0.90 (0.29-2.8) | .853 | ||
| Other baseline conditions | ||||
| Coronary artery disease | 1.2 (0.68-2.0) | .568 | ||
| Heart failure | 1.5 (0.89-2.5) | .129 | ||
| Renal insufficiency | 1.7 (1.1-2.8) | .026 | 1.4 (0.86-2.1) | .185 |
| Diabetes mellitus | 2.9 (1.2-3.3) | .007 | 1.4 (0.85-2.2) | .195 |
| Arterial hypertension | 0.84 (0.51-1.4) | .501 | ||
| Time (per week) | 0.73 (0.68-0.79) | <.0001 | 0.86 (0.79-0.94) | .0015 |
| Parameter . | Univariate IRR (95% CI) . | P . | Multivariate IRR (95% CI) . | P . |
|---|---|---|---|---|
| FVIII activity category | ||||
| <1% | 7.4 (3.1-18) | <.0001 | 7.1 (3.1-16) | <.0001 |
| 1 to <5% | 7.5 (3.3-17) | <.0001 | 8.2 (3.7-18) | <.0001 |
| 5 to <20% | 6.4 (2.9-14) | <.0001 | 6.5 (3.0-14) | <.0001 |
| 20 to <50% | 4.4 (2.0-9.6) | .0002 | 4.6 (2.1-10) | <.0001 |
| ≥50% | 1 | 1 | ||
| Age (per year) | 1.01 (0.99-1.02) | .537 | ||
| Body weight (per kg) | 1.02 (1.00-1.03) | .054 | ||
| Female sex | 0.90 (0.55-1.5) | .682 | ||
| WHO performance status | ||||
| 0 (best) | 0.32 (0.12-0.89) | .029 | 0.23 (0.09-0.62) | .004 |
| 1 | 0.86 (0.42-1.8) | .691 | 0.61 (0.31-1.2) | .151 |
| 2 | 0.91 (0.42-1.9) | .805 | 0.63 (0.31-1.3) | .211 |
| 3 | 1.3 (0.65-2.8) | .426 | 0.81 (0.41-1.6) | .552 |
| 4 or 5 (worst) | 1 | 1 | ||
| Underlying disorders | ||||
| Malignancy | 0.47 (0.19-1.1) | .095 | ||
| Autoimmunity | 1.0 (0.55-1.8) | .986 | ||
| Pregnancy | 0.90 (0.29-2.8) | .853 | ||
| Other baseline conditions | ||||
| Coronary artery disease | 1.2 (0.68-2.0) | .568 | ||
| Heart failure | 1.5 (0.89-2.5) | .129 | ||
| Renal insufficiency | 1.7 (1.1-2.8) | .026 | 1.4 (0.86-2.1) | .185 |
| Diabetes mellitus | 2.9 (1.2-3.3) | .007 | 1.4 (0.85-2.2) | .195 |
| Arterial hypertension | 0.84 (0.51-1.4) | .501 | ||
| Time (per week) | 0.73 (0.68-0.79) | <.0001 | 0.86 (0.79-0.94) | .0015 |
Incidence rate ratios (IRRs) corresponding to exp(B) from generalized linear mixed model of weekly bleeding rate (dependent variable, utilizing negative binomial distribution, and log link function) with indicated parameters. Age, body weight, and time were entered as continuous factors. All other parameters were entered as categorical factors as indicated. Univariate IRRs were corrected for time. Multivariate IRRs were corrected for time and the parameters achieving a significance level of P < .05 in univariate analyses.