Cumulative incidence of toxicities over time after CAR T-cell infusion
| Toxicities by system . | 1 mo, % (95% CI) . | 3 mo, % (95% CI) . | 6 mo, % (95% CI) . | 1 y, % (95% CI) . | ||||
|---|---|---|---|---|---|---|---|---|
| Grade ≥2 . | Grade ≥3 . | Grade ≥2 . | Grade ≥3 . | Grade ≥2 . | Grade ≥3 . | Grade ≥2 . | Grade ≥3 . | |
| Cardiovascular based | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) |
| Metabolic based | 73.3 (59.9-82.9) | 45.0 (32.0-57.1) | 75.0 (61.7-84.3) | 48.3 (35.1-60.3) | 78.5 (65.3-87.2) | 51.8 (38.3-63.7) | 78.5 (65.3-87.2) | 54.8 (40.5-67.1) |
| Hematologic based | 15.0 (7.3-25.2) | 1.7 (0.1-7.9) | 66.7 (53.0-77.2) | 53.3 (39.8-65.1) | 66.7 (53.0-77.2) | 55.0 (41.4-66.7) | 69.7 (55.0-80.4) | 57.7 (43.4-69.9) |
| Pulmonary based | 28.3 (17.5-40.1) | 10.0 (4.0-19.2) | 30.0 (18.9-41.9) | 11.7 (5.1-21.2) | 31.7 (20.3-43.6) | 13.3 (6.2-23.3) | 36.3 (23.8-48.9) | 13.3 (6.2-23.3) |
| Neurology based | 40.0 (27.5-52.2) | 18.3 (9.7-29.1) | 41.7 (29.0-53.8) | 18.3 (9.7-29.1) | 43.3 (30.5-55.5) | 18.3 (9.7-29.1) | 46.0 (32.5-58.5) | 18.3 (9.7-29.1) |
| Infection with identified pathogen/source | 48.3 (35.1-60.3) | 18.3 (9.7-29.1) | 53.3 (39.8-65.1) | 21.7 (12.2-32.9) | 58.3 (44.6-69.8) | 28.3 (17.5-40.1) | 63.1 (48.6-74.6) | 35.4 (22.6-48.4) |
| Toxicities by system . | 1 mo, % (95% CI) . | 3 mo, % (95% CI) . | 6 mo, % (95% CI) . | 1 y, % (95% CI) . | ||||
|---|---|---|---|---|---|---|---|---|
| Grade ≥2 . | Grade ≥3 . | Grade ≥2 . | Grade ≥3 . | Grade ≥2 . | Grade ≥3 . | Grade ≥2 . | Grade ≥3 . | |
| Cardiovascular based | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) | 53.3 (39.8-65.1) | 16.7 (8.5-27.2) |
| Metabolic based | 73.3 (59.9-82.9) | 45.0 (32.0-57.1) | 75.0 (61.7-84.3) | 48.3 (35.1-60.3) | 78.5 (65.3-87.2) | 51.8 (38.3-63.7) | 78.5 (65.3-87.2) | 54.8 (40.5-67.1) |
| Hematologic based | 15.0 (7.3-25.2) | 1.7 (0.1-7.9) | 66.7 (53.0-77.2) | 53.3 (39.8-65.1) | 66.7 (53.0-77.2) | 55.0 (41.4-66.7) | 69.7 (55.0-80.4) | 57.7 (43.4-69.9) |
| Pulmonary based | 28.3 (17.5-40.1) | 10.0 (4.0-19.2) | 30.0 (18.9-41.9) | 11.7 (5.1-21.2) | 31.7 (20.3-43.6) | 13.3 (6.2-23.3) | 36.3 (23.8-48.9) | 13.3 (6.2-23.3) |
| Neurology based | 40.0 (27.5-52.2) | 18.3 (9.7-29.1) | 41.7 (29.0-53.8) | 18.3 (9.7-29.1) | 43.3 (30.5-55.5) | 18.3 (9.7-29.1) | 46.0 (32.5-58.5) | 18.3 (9.7-29.1) |
| Infection with identified pathogen/source | 48.3 (35.1-60.3) | 18.3 (9.7-29.1) | 53.3 (39.8-65.1) | 21.7 (12.2-32.9) | 58.3 (44.6-69.8) | 28.3 (17.5-40.1) | 63.1 (48.6-74.6) | 35.4 (22.6-48.4) |