TEAEs occurring in >15% of patients
| . | Total (n = 48) (%) . | |||||
|---|---|---|---|---|---|---|
| All grades . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . | |
| Subjects with at least 1 TEAE | 48 (100.0) | 6 (12.5) | 19 (39.6) | 17 (35.4) | 4 (8.3) | 2 (4.2) |
| Headache | 33 (68.8) | 25 (52.1) | 8 (16.7) | 0 | 0 | 0 |
| Contusion | 27 (56.3) | 27 (56.3) | 0 | 0 | 0 | 0 |
| Diarrhea | 21 (43.8) | 20 (41.7) | 1 (2.1) | 0 | 0 | 0 |
| Upper respiratory tract infection | 20 (41.7) | 2 (4.2) | 18 (37.5) | 0 | 0 | 0 |
| Influenza-like illness | 18 (37.5) | 15 (31.3) | 3 (6.3) | 0 | 0 | 0 |
| Myalgia | 18 (37.5) | 16 (33.3) | 2 (4.2) | 0 | 0 | 0 |
| Arthralgia | 16 (33.3) | 9 (18.8) | 7 (14.6) | 0 | 0 | 0 |
| Maculopapular rash | 16 (33.3) | 15 (31.3) | 0 | 1 (2.1) | 0 | 0 |
| Petechiae | 14 (29.2) | 14 (29.2) | 0 | 0 | 0 | 0 |
| Nausea | 13 (27.1) | 13 (27.1) | 0 | 0 | 0 | 0 |
| Cough | 11 (22.9) | 11 (22.9) | 0 | 0 | 0 | 0 |
| Dizziness | 11 (22.9) | 11 (22.9) | 0 | 0 | 0 | 0 |
| Nasal congestion | 11 (22.9) | 9 (18.8) | 2 (4.2) | 0 | 0 | 0 |
| Dyspnea | 10 (20.8) | 9 (18.8) | 1 (2.1) | 0 | 0 | 0 |
| Fatigue | 10 (20.8) | 9 (18.8) | 1 (2.1) | 0 | 0 | 0 |
| Pyrexia | 10 (20.8) | 9 (18.8) | 1 (2.1) | 0 | 0 | 0 |
| Neutropenia* | 9 (18.8) | 1 (2.1) | 2 (4.2) | 3 (6.3) | 3 (6.3) | 0 |
| Peripheral edema | 9 (18.8) | 9 (18.8) | 0 | 0 | 0 | 0 |
| Thrombocytopenia | 9 (18.8) | 3 (6.3) | 3 (6.3) | 2 (4.2) | 1 (2.1) | 0 |
| Lung infection | 8 (16.7) | 0 | 4 (8.3) | 4 (8.3) | 0 | 0 |
| Sinusitis | 8 (16.7) | 0 | 8 (16.7) | 0 | 0 | 0 |
| Urinary tract infection | 8 (16.7) | 0 | 7 (14.6) | 1 (2.1) | 0 | 0 |
| . | Total (n = 48) (%) . | |||||
|---|---|---|---|---|---|---|
| All grades . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . | |
| Subjects with at least 1 TEAE | 48 (100.0) | 6 (12.5) | 19 (39.6) | 17 (35.4) | 4 (8.3) | 2 (4.2) |
| Headache | 33 (68.8) | 25 (52.1) | 8 (16.7) | 0 | 0 | 0 |
| Contusion | 27 (56.3) | 27 (56.3) | 0 | 0 | 0 | 0 |
| Diarrhea | 21 (43.8) | 20 (41.7) | 1 (2.1) | 0 | 0 | 0 |
| Upper respiratory tract infection | 20 (41.7) | 2 (4.2) | 18 (37.5) | 0 | 0 | 0 |
| Influenza-like illness | 18 (37.5) | 15 (31.3) | 3 (6.3) | 0 | 0 | 0 |
| Myalgia | 18 (37.5) | 16 (33.3) | 2 (4.2) | 0 | 0 | 0 |
| Arthralgia | 16 (33.3) | 9 (18.8) | 7 (14.6) | 0 | 0 | 0 |
| Maculopapular rash | 16 (33.3) | 15 (31.3) | 0 | 1 (2.1) | 0 | 0 |
| Petechiae | 14 (29.2) | 14 (29.2) | 0 | 0 | 0 | 0 |
| Nausea | 13 (27.1) | 13 (27.1) | 0 | 0 | 0 | 0 |
| Cough | 11 (22.9) | 11 (22.9) | 0 | 0 | 0 | 0 |
| Dizziness | 11 (22.9) | 11 (22.9) | 0 | 0 | 0 | 0 |
| Nasal congestion | 11 (22.9) | 9 (18.8) | 2 (4.2) | 0 | 0 | 0 |
| Dyspnea | 10 (20.8) | 9 (18.8) | 1 (2.1) | 0 | 0 | 0 |
| Fatigue | 10 (20.8) | 9 (18.8) | 1 (2.1) | 0 | 0 | 0 |
| Pyrexia | 10 (20.8) | 9 (18.8) | 1 (2.1) | 0 | 0 | 0 |
| Neutropenia* | 9 (18.8) | 1 (2.1) | 2 (4.2) | 3 (6.3) | 3 (6.3) | 0 |
| Peripheral edema | 9 (18.8) | 9 (18.8) | 0 | 0 | 0 | 0 |
| Thrombocytopenia | 9 (18.8) | 3 (6.3) | 3 (6.3) | 2 (4.2) | 1 (2.1) | 0 |
| Lung infection | 8 (16.7) | 0 | 4 (8.3) | 4 (8.3) | 0 | 0 |
| Sinusitis | 8 (16.7) | 0 | 8 (16.7) | 0 | 0 | 0 |
| Urinary tract infection | 8 (16.7) | 0 | 7 (14.6) | 1 (2.1) | 0 | 0 |
Included neutropenia and neutrophil count decrease.