Table 3. Definitions of deep hematologic... | American Society of Hematology

Table 3.

Definitions of deep hematologic responses in AL amyloidosis are evolving

Parameter	Complete response			Modified complete response*	Stringent dFLC response*	Absolute iFLC response*
Parameter	Gertz 2005³⁷	Comenzo 2012¹⁴	Palladini 2012⁵³	AMY3001 2020	Manwani 2019⁴⁴	Muchtar 2019⁴³
Negative serum IFE	✓	✓	✓	✓	Not required	Not required
Negative urine IFE	✓	✓	✓	✓	Not required	Not required
Bone marrow plasma cells <5%	✓	Not required	Not required	Not required	Not required	Not required
FLC	Normal levels	Normal levels	Not required	iFLC <ULN	dFLC <10 mg/L	iFLC ≤20 mg/L
FLC ratio (normal)	✓	✓	✓	Not required	Not required	Not required

Parameter	Complete response			Modified complete response*	Stringent dFLC response*	Absolute iFLC response*
Parameter	Gertz 2005³⁷	Comenzo 2012¹⁴	Palladini 2012⁵³	AMY3001 2020	Manwani 2019⁴⁴	Muchtar 2019⁴³
Negative serum IFE	✓	✓	✓	✓	Not required	Not required
Negative urine IFE	✓	✓	✓	✓	Not required	Not required
Bone marrow plasma cells <5%	✓	Not required	Not required	Not required	Not required	Not required
FLC	Normal levels	Normal levels	Not required	iFLC <ULN	dFLC <10 mg/L	iFLC ≤20 mg/L
FLC ratio (normal)	✓	✓	✓	Not required	Not required	Not required

Pending validation and international consensus agreement.