Expression level of NF-κB target genes involved in ROS protection from RNAseq analysis of the spleen of Hbbth3/+and Tfr2BMKO/Hbbth3/+mice
| Gene name . | Hbbth3/+ . | Tfr2BMKO/Hbbth3/+ . | P (DESeq2)* . | padj (IHW)† . |
|---|---|---|---|---|
| Sod2 (MnSOD) | 41.02 ± 0.73 | 51.43 ± 3.26 | .006551 | .056003 |
| Sod1 (CuZnSOD) | 1205.18 ± 100.71 | 1617.59 ± 98.45 | .005153 | .045185 |
| FtH1 | 5377.17 ± 414.93 | 6666.98 ± 593.60 | .030397 | .134317 |
| Txn1 | 627.74 ± 18.86 | 735.73 ± 80.39 | .054498 | .195756 |
| Txn2 | 74.12 ± 5.09 | 92.57 ± 3.54 | .014006 | .083579 |
| GSTp1 | 124.66 ± 11.92 | 171.08 ± 17.92 | .00604 | .059385 |
| Gene name . | Hbbth3/+ . | Tfr2BMKO/Hbbth3/+ . | P (DESeq2)* . | padj (IHW)† . |
|---|---|---|---|---|
| Sod2 (MnSOD) | 41.02 ± 0.73 | 51.43 ± 3.26 | .006551 | .056003 |
| Sod1 (CuZnSOD) | 1205.18 ± 100.71 | 1617.59 ± 98.45 | .005153 | .045185 |
| FtH1 | 5377.17 ± 414.93 | 6666.98 ± 593.60 | .030397 | .134317 |
| Txn1 | 627.74 ± 18.86 | 735.73 ± 80.39 | .054498 | .195756 |
| Txn2 | 74.12 ± 5.09 | 92.57 ± 3.54 | .014006 | .083579 |
| GSTp1 | 124.66 ± 11.92 | 171.08 ± 17.92 | .00604 | .059385 |
Data are indicated as median of the TPM plus or minus standard error of the mean.
FtH1, ferritin heavy chain 1; GSTp1, glutathione S-transferase P1; IHW, independent hypothesis weighting; padj, adjusted P value; ROS, reactive oxygen species; Sod, superoxide dismutase; TPM, transcripts per kilobase million; Txn, thioredoxin.
The P value has been calculated using the DESeq2 algorithm.
The adjusted P value has been obtained using the IHW correction.