Signature of 23 microRNAs differentially expressed in RS vs control samples
| Gene name . | Control . | RS . | Linear FC: control vs RS . | P (control vs RS) . | Predictors . |
|---|---|---|---|---|---|
| hsa-miR-145-5p | 4.69 | 23.56 | −5.02 | .0064 | |
| hsa-miR-125a-5p | 6.67 | 31.88 | −4.78 | .0028 | Selected |
| hsa-miR-548al | 6.78 | 22.81 | −3.36 | .0135 | |
| hsa-miR-365a-3p+hsa-miR-365b-3p | 16.98 | 51.25 | −3.02 | .0014 | |
| hsa-miR-181a-5p | 156.83 | 466.26 | −2.97 | .0000 | Not selected* |
| hsa-miR-199a-3p+hsa-miR-199b-3p | 28.57 | 78.04 | −2.73 | .0164 | |
| hsa-miR-223-3p | 6293.79 | 16 777.22 | −2.67 | .0011 | Not selected |
| hsa-miR-582-5p | 18.97 | 50.19 | −2.65 | .0417 | |
| hsa-miR-221-3p | 21.87 | 53.66 | −2.45 | .0492 | |
| hsa-miR-126-3p | 138.26 | 322.04 | −2.33 | .0302 | Not selected |
| hsa-miR-451a | 525.34 | 1 161.25 | −2.21 | .0445 | Not selected |
| hsa-miR-337-3p | 101.18 | 49.08 | 2.06 | .0021 | |
| hsa-miR-32-5p | 401.21 | 176.95 | 2.27 | .0061 | |
| hsa-miR-1260b | 33.1 | 14.47 | 2.29 | .0032 | |
| hsa-miR-486-3p | 76.1 | 33.17 | 2.29 | .0159 | |
| hsa-miR-630 | 81.35 | 35.09 | 2.32 | .0387 | |
| hsa-miR-335-5p | 90.02 | 38.14 | 2.36 | .0074 | Not selected |
| hsa-miR-601 | 64.24 | 24.89 | 2.58 | .0138 | Not selected |
| hsa-miR-502-5p | 108.82 | 37.92 | 2.87 | .0003 | Not selected |
| hsa-miR-195-5p | 36.24 | 11.35 | 3.19 | .0010 | Not selected |
| hsa-miR-142-5p | 119.03 | 36.68 | 3.25 | .0036 | Not selected |
| hsa-miR-34a-5p | 86.95 | 17.08 | 5.09 | .0031 | Selected |
| hsa-miR-570-3p | 22.64 | 3.78 | 5.99 | .0001 | Not selected |
| Gene name . | Control . | RS . | Linear FC: control vs RS . | P (control vs RS) . | Predictors . |
|---|---|---|---|---|---|
| hsa-miR-145-5p | 4.69 | 23.56 | −5.02 | .0064 | |
| hsa-miR-125a-5p | 6.67 | 31.88 | −4.78 | .0028 | Selected |
| hsa-miR-548al | 6.78 | 22.81 | −3.36 | .0135 | |
| hsa-miR-365a-3p+hsa-miR-365b-3p | 16.98 | 51.25 | −3.02 | .0014 | |
| hsa-miR-181a-5p | 156.83 | 466.26 | −2.97 | .0000 | Not selected* |
| hsa-miR-199a-3p+hsa-miR-199b-3p | 28.57 | 78.04 | −2.73 | .0164 | |
| hsa-miR-223-3p | 6293.79 | 16 777.22 | −2.67 | .0011 | Not selected |
| hsa-miR-582-5p | 18.97 | 50.19 | −2.65 | .0417 | |
| hsa-miR-221-3p | 21.87 | 53.66 | −2.45 | .0492 | |
| hsa-miR-126-3p | 138.26 | 322.04 | −2.33 | .0302 | Not selected |
| hsa-miR-451a | 525.34 | 1 161.25 | −2.21 | .0445 | Not selected |
| hsa-miR-337-3p | 101.18 | 49.08 | 2.06 | .0021 | |
| hsa-miR-32-5p | 401.21 | 176.95 | 2.27 | .0061 | |
| hsa-miR-1260b | 33.1 | 14.47 | 2.29 | .0032 | |
| hsa-miR-486-3p | 76.1 | 33.17 | 2.29 | .0159 | |
| hsa-miR-630 | 81.35 | 35.09 | 2.32 | .0387 | |
| hsa-miR-335-5p | 90.02 | 38.14 | 2.36 | .0074 | Not selected |
| hsa-miR-601 | 64.24 | 24.89 | 2.58 | .0138 | Not selected |
| hsa-miR-502-5p | 108.82 | 37.92 | 2.87 | .0003 | Not selected |
| hsa-miR-195-5p | 36.24 | 11.35 | 3.19 | .0010 | Not selected |
| hsa-miR-142-5p | 119.03 | 36.68 | 3.25 | .0036 | Not selected |
| hsa-miR-34a-5p | 86.95 | 17.08 | 5.09 | .0031 | Selected |
| hsa-miR-570-3p | 22.64 | 3.78 | 5.99 | .0001 | Not selected |
Samples from Cohort 1 (21 RS) and Cohort 2 (14 controls) were assayed using NanoString technology. Mir-125a-5p and miR-34a-5p were selected for further studies in an independent validation set. The Student t test was applied for differential expression analysis.
FC, fold change.
Mir-181a-5p was initially selected but not confirmed in the validation experiment.