Adjusted and unadjusted risks of mortality and need for persistent ventilation for patients having baseline platelet counts less than 80 000 plt/μL (coagulation failure) or sTLT-1 levels greater than 1200 pg/mL on day 1 and day 3
| Outcome . | Coagulation failure . | sTLT-1 1200 day 1 . | sTLT-1 1200 day 3 . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR* . | 95% CI . | P* . | ROC . | OR* . | 95% CI . | P* . | ROC . | OR* . | 95% CI . | P* . | ROC . | |
| Mortality | ||||||||||||
| Unadjusted | 1.568 | 1.135-2.167 | .003 | 0.545 | 2.155 | 1.595-2.912 | <.001 | 0.588 | 1.81 | 1.296-2.530 | .001 | 0.569 |
| Adjusted | NS | NS | NS | 1.91 | 1.376-2.651 | <.001 | 1.726 | 1.201-2.479 | .003 | |||
| Required persistent ventilation | ||||||||||||
| Unadjusted | 1.522 | 1.100-2.105 | .011 | 1.645 | 1.223-2.214 | .002 | 1.616 | 1.157-2.257 | .006 | |||
| Adjusted | NS | NS | NS | 1.423 | 1.032-1.96 | .032 | 1.499 | 1.049-2.142 | .026 | |||
| Outcome . | Coagulation failure . | sTLT-1 1200 day 1 . | sTLT-1 1200 day 3 . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR* . | 95% CI . | P* . | ROC . | OR* . | 95% CI . | P* . | ROC . | OR* . | 95% CI . | P* . | ROC . | |
| Mortality | ||||||||||||
| Unadjusted | 1.568 | 1.135-2.167 | .003 | 0.545 | 2.155 | 1.595-2.912 | <.001 | 0.588 | 1.81 | 1.296-2.530 | .001 | 0.569 |
| Adjusted | NS | NS | NS | 1.91 | 1.376-2.651 | <.001 | 1.726 | 1.201-2.479 | .003 | |||
| Required persistent ventilation | ||||||||||||
| Unadjusted | 1.522 | 1.100-2.105 | .011 | 1.645 | 1.223-2.214 | .002 | 1.616 | 1.157-2.257 | .006 | |||
| Adjusted | NS | NS | NS | 1.423 | 1.032-1.96 | .032 | 1.499 | 1.049-2.142 | .026 | |||
Risks are presented as odds ratios (ORs) and are defined as mortality and requirement persistent ventilation. ORs for distributions of nominal and ordinal data were calculated using the Cochran-Mantel-Haenszel method, and binary logistic analysis controlling for covariates (age, creatinine, APACHE III, ventilation volume, ethnicity, thrombocytopenia, and drug type) was used to calculate ORs for mortality, and persistent ventilation, between platelet count or sTLT-1 stratifications.
CI, confidence interval; ROC, receiver operator characteristic.