Adverse events occurring in at least 3% of patients after 4 cycles of PCD (n = 100)
| . | Grade 1 to 2, n (%) . | Grade 3 to 4, n (%) . |
|---|---|---|
| Adverse event | 97 (97%) | 73 (73%) |
| Blood and lymphatic system disorders | 25 (25%) | 100 (100%) |
| Anemia | 9 (9%) | 7 (7%) |
| Neutropenia | 8 (8%) | 51 (51%) |
| Lymphopenia | 4 (4%) | 37 (37%) |
| Thrombocytopenia | 4 (4%) | 5 (5%) |
| Gastrointestinal disorders | 71 (71%) | 2 (2%) |
| Constipation | 23 (23%) | 1 (1%) |
| Diarrhea | 16 (16%) | 0 (0%) |
| Nausea | 12 (12%) | 0 (0%) |
| Abdominal pain (upper) | 11 (11%) | 1 (1%) |
| Vomiting | 5 (5%) | 0 (0%) |
| Hemorrhoids | 4 (4%) | 0 (0%) |
| Constitutional | 65 (65%) | 3 (3%) |
| Asthenia | 50 (50%) | 3 (3%) |
| Edema (peripheral) | 15 (15%) | 0 (0%) |
| Immune system disorders | 8 (8%) | 3 (3%) |
| Hypersensitivity | 8 (8%) | 3 (3%) |
| Infections | 49 (49%) | 6 (6%) |
| Bronchitis | 25 (25%) | 0 (0%) |
| Nasopharyngitis | 9 (9%) | 0 (0%) |
| Gastroenteritis | 8 (8%) | 0 (0%) |
| Sinusitis | 4 (4%) | 0 (0%) |
| Pneumonia | 3 (3%) | 6 (6%) |
| Metabolism | 7 (7%) | 4 (3%) |
| Hyperglycemia | 4 (4%) | 4 (3%) |
| Hypokalemia | 3 (3%) | 0 (0%) |
| Musculoskeletal | 51 (51%) | 2 (2%) |
| Muscle spasms | 22 (22%) | 0 (0%) |
| Bone pain | 20 (20%) | 2 (2%) |
| Muscular weakness | 5 (5%) | 0 (0%) |
| Myalgia | 4 (4%) | 0 (0%) |
| Nervous system disorders | 25 (25%) | 0 (0%) |
| Tremor | 14 (14%) | 0 (0%) |
| Peripheral sensory neuropathy | 7 (7%) | 0 (0%) |
| Dysesthesia | 4 (4%) | 0 (0%) |
| Psychiatric disorders | 47 (47%) | 1 (1%) |
| Insomnia | 22 (22%) | 1 (1%) |
| Irritability | 7 (7%) | 0 (0%) |
| Sleep disorder | 6 (6%) | 0 (0%) |
| Agitation | 4 (4%) | 0 (0%) |
| Anxiety | 4 (4%) | 0 (0%) |
| Depression | 4 (4%) | 0 (0%) |
| Respiratory, thoracic and mediastinal disorders | 39 (39%) | 3 (3%) |
| Dyspnea | 15 (15%) | 2 (2%) |
| Cough | 11 (11%) | 1 (1%) |
| Dysphonia | 5 (5%) | 0 (0%) |
| Dyspnea exertional | 4 (4%) | 0 (0%) |
| Hiccups | 4 (4%) | 0 (0%) |
| Skin disorders | 25 (25%) | 1 (1%) |
| Rash | 10 (10%) | 1 (1%) |
| Erythema | 9 (9%) | 0 (0%) |
| Hyperhidrosis | 6 (6%) | 0 (0%) |
| Vascular disorders | 5 (5%) | 0 (0%) |
| Flushing | 5 (5%) | 0 (0%) |
| . | Grade 1 to 2, n (%) . | Grade 3 to 4, n (%) . |
|---|---|---|
| Adverse event | 97 (97%) | 73 (73%) |
| Blood and lymphatic system disorders | 25 (25%) | 100 (100%) |
| Anemia | 9 (9%) | 7 (7%) |
| Neutropenia | 8 (8%) | 51 (51%) |
| Lymphopenia | 4 (4%) | 37 (37%) |
| Thrombocytopenia | 4 (4%) | 5 (5%) |
| Gastrointestinal disorders | 71 (71%) | 2 (2%) |
| Constipation | 23 (23%) | 1 (1%) |
| Diarrhea | 16 (16%) | 0 (0%) |
| Nausea | 12 (12%) | 0 (0%) |
| Abdominal pain (upper) | 11 (11%) | 1 (1%) |
| Vomiting | 5 (5%) | 0 (0%) |
| Hemorrhoids | 4 (4%) | 0 (0%) |
| Constitutional | 65 (65%) | 3 (3%) |
| Asthenia | 50 (50%) | 3 (3%) |
| Edema (peripheral) | 15 (15%) | 0 (0%) |
| Immune system disorders | 8 (8%) | 3 (3%) |
| Hypersensitivity | 8 (8%) | 3 (3%) |
| Infections | 49 (49%) | 6 (6%) |
| Bronchitis | 25 (25%) | 0 (0%) |
| Nasopharyngitis | 9 (9%) | 0 (0%) |
| Gastroenteritis | 8 (8%) | 0 (0%) |
| Sinusitis | 4 (4%) | 0 (0%) |
| Pneumonia | 3 (3%) | 6 (6%) |
| Metabolism | 7 (7%) | 4 (3%) |
| Hyperglycemia | 4 (4%) | 4 (3%) |
| Hypokalemia | 3 (3%) | 0 (0%) |
| Musculoskeletal | 51 (51%) | 2 (2%) |
| Muscle spasms | 22 (22%) | 0 (0%) |
| Bone pain | 20 (20%) | 2 (2%) |
| Muscular weakness | 5 (5%) | 0 (0%) |
| Myalgia | 4 (4%) | 0 (0%) |
| Nervous system disorders | 25 (25%) | 0 (0%) |
| Tremor | 14 (14%) | 0 (0%) |
| Peripheral sensory neuropathy | 7 (7%) | 0 (0%) |
| Dysesthesia | 4 (4%) | 0 (0%) |
| Psychiatric disorders | 47 (47%) | 1 (1%) |
| Insomnia | 22 (22%) | 1 (1%) |
| Irritability | 7 (7%) | 0 (0%) |
| Sleep disorder | 6 (6%) | 0 (0%) |
| Agitation | 4 (4%) | 0 (0%) |
| Anxiety | 4 (4%) | 0 (0%) |
| Depression | 4 (4%) | 0 (0%) |
| Respiratory, thoracic and mediastinal disorders | 39 (39%) | 3 (3%) |
| Dyspnea | 15 (15%) | 2 (2%) |
| Cough | 11 (11%) | 1 (1%) |
| Dysphonia | 5 (5%) | 0 (0%) |
| Dyspnea exertional | 4 (4%) | 0 (0%) |
| Hiccups | 4 (4%) | 0 (0%) |
| Skin disorders | 25 (25%) | 1 (1%) |
| Rash | 10 (10%) | 1 (1%) |
| Erythema | 9 (9%) | 0 (0%) |
| Hyperhidrosis | 6 (6%) | 0 (0%) |
| Vascular disorders | 5 (5%) | 0 (0%) |
| Flushing | 5 (5%) | 0 (0%) |