Table 1.

Summary results for newly identified Hodgkin lymphoma risk loci

LocusNearest genes*RiskDiscovery GWAS meta-analysisUK BiobankUSC-IARC-UC-GWASMeta-analysis
Allele (freq)Position (hg19, bp)POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)I2, %Phet
1p13.2, rs2476601 PTPN22 A (0.12) 114377568 3.92 × 10−3 1.15 (1.04-1.26) 3.21 × 10−4 1.42 (1.17-1.72) 3.70 × 10−3 1.24 (1.07-1.44)† 4.20 × 10−7 1.21 (1.12-1.30) 20 .29 
6p21.31, rs649775 ITPR3- UQCC2-IP6K3 A (0.11) 33684313 4.00 × 10−6 1.25 (1.14-1.38) — — 8.22 × 10−6 1.36 (1.19-1.55) 2.11× 10−10 1.29 (1.19-1.40) 0 .54 
6q23.3, rs1002658 OLIG3-TNFAIP3 T (0.18) 137981584 3.86 × 10−6 1.19 (1.11-1.28) — — 2.15 × 10−3 1.18 (1.06-1.31) 2.97 × 10−8 1.19 (1.12-1.26) 0 .53 
11q23.1, rs7111520 POU2AF1 A (0.70) 111249611 4.33 × 10−7 1.17 (1.10-1.24) — — 4.39 × 10−6 1.24 (1.13-1.35) 1.44 × 10−11 1.19 (1.13-1.25) 0 .68 
16p11.2, rs6565176 MAPK3-CORO1A T (0.48) 30174926 8.64 × 10−6 1.14 (1.08-1.21) 3.44 × 10−4 1.28 (1.10-1.23) — — 4.00 × 10−8 1.16 (1.10-1.22) 0 .46 
20q13.12, rs2425752 NCOA5-CD40 T (0.23) 44702120 2.23 × 10−4 1.13 (1.06-1.20) 2.94 × 10−4 1.30 (1.12-1.50) 3.77 × 10−3 1.14 (1.09-1.20) 2.01 × 10−8 1.15 (1.10-1.21) 56 .06 
LocusNearest genes*RiskDiscovery GWAS meta-analysisUK BiobankUSC-IARC-UC-GWASMeta-analysis
Allele (freq)Position (hg19, bp)POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)I2, %Phet
1p13.2, rs2476601 PTPN22 A (0.12) 114377568 3.92 × 10−3 1.15 (1.04-1.26) 3.21 × 10−4 1.42 (1.17-1.72) 3.70 × 10−3 1.24 (1.07-1.44)† 4.20 × 10−7 1.21 (1.12-1.30) 20 .29 
6p21.31, rs649775 ITPR3- UQCC2-IP6K3 A (0.11) 33684313 4.00 × 10−6 1.25 (1.14-1.38) — — 8.22 × 10−6 1.36 (1.19-1.55) 2.11× 10−10 1.29 (1.19-1.40) 0 .54 
6q23.3, rs1002658 OLIG3-TNFAIP3 T (0.18) 137981584 3.86 × 10−6 1.19 (1.11-1.28) — — 2.15 × 10−3 1.18 (1.06-1.31) 2.97 × 10−8 1.19 (1.12-1.26) 0 .53 
11q23.1, rs7111520 POU2AF1 A (0.70) 111249611 4.33 × 10−7 1.17 (1.10-1.24) — — 4.39 × 10−6 1.24 (1.13-1.35) 1.44 × 10−11 1.19 (1.13-1.25) 0 .68 
16p11.2, rs6565176 MAPK3-CORO1A T (0.48) 30174926 8.64 × 10−6 1.14 (1.08-1.21) 3.44 × 10−4 1.28 (1.10-1.23) — — 4.00 × 10−8 1.16 (1.10-1.22) 0 .46 
20q13.12, rs2425752 NCOA5-CD40 T (0.23) 44702120 2.23 × 10−4 1.13 (1.06-1.20) 2.94 × 10−4 1.30 (1.12-1.50) 3.77 × 10−3 1.14 (1.09-1.20) 2.01 × 10−8 1.15 (1.10-1.21) 56 .06 

freq, frequency; I2, proportion of the total variation resulting from heterogeneity.

*

Genes at each risk locus are given for identification purposes only and does not necessarily indicate biological functionality.

†

Summary statistics from 1200 patients with cHL and 6417 control patients.26 

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