Association between PRS composed of 23 SNPs and risk of MM or MGUS
| PRS (range), % . | Counts . | MM risk . | Counts . | MGUS risk . | ||||
|---|---|---|---|---|---|---|---|---|
| MM (n = 2434) . | InterLymph controls (n = 2567) . | OR (95% CI) . | P . | MGUS (n = 754) . | OncoArray Controls (n = 879) . | OR (95% CI) . | P . | |
| Q1 (<20) | 288 | 496 | 0.71 (0.55-0.90) | .005 | 109 | 202 | 0.70 (0.50-0.98) | .04 |
| Q2 (20-40) | 374 | 506 | 0.84 (0.67-1.06) | .14 | 126 | 165 | 0.98 (0.70-1.38) | .92 |
| Q3 (40-60) | 452 | 527 | Reference | 121 | 158 | Reference | ||
| Q4 (60-80) | 502 | 524 | 1.14 (0.92-1.42) | .23 | 162 | 172 | 1.21 (0.88-1.69) | .24 |
| Q5 (80-100) | 818 | 515 | 1.70 (1.38-2.09) | 5.2 × 10−07 | 236 | 182 | 1.77 (1.29-2.43) | .0004 |
| Continuous (per SD) | 1.17 (1.13-1.21) | 2.2 × 10−16 | 1.19 (1.14-1.26) | 2.77 × 10−12 | ||||
| Mean PRS (SD) | 3.23 (0.48) | 3.06 (0.47) | 3.19 (0.50) | 3.02 (0.47) | ||||
| Median PRS (range) | 3.21 (1.63-4.91) | 3.06 (1.61-4.70) | 3.19 (1.69-4.64) | 3.03 (1.52-4.63) | ||||
| PRS (range), % . | Counts . | MM risk . | Counts . | MGUS risk . | ||||
|---|---|---|---|---|---|---|---|---|
| MM (n = 2434) . | InterLymph controls (n = 2567) . | OR (95% CI) . | P . | MGUS (n = 754) . | OncoArray Controls (n = 879) . | OR (95% CI) . | P . | |
| Q1 (<20) | 288 | 496 | 0.71 (0.55-0.90) | .005 | 109 | 202 | 0.70 (0.50-0.98) | .04 |
| Q2 (20-40) | 374 | 506 | 0.84 (0.67-1.06) | .14 | 126 | 165 | 0.98 (0.70-1.38) | .92 |
| Q3 (40-60) | 452 | 527 | Reference | 121 | 158 | Reference | ||
| Q4 (60-80) | 502 | 524 | 1.14 (0.92-1.42) | .23 | 162 | 172 | 1.21 (0.88-1.69) | .24 |
| Q5 (80-100) | 818 | 515 | 1.70 (1.38-2.09) | 5.2 × 10−07 | 236 | 182 | 1.77 (1.29-2.43) | .0004 |
| Continuous (per SD) | 1.17 (1.13-1.21) | 2.2 × 10−16 | 1.19 (1.14-1.26) | 2.77 × 10−12 | ||||
| Mean PRS (SD) | 3.23 (0.48) | 3.06 (0.47) | 3.19 (0.50) | 3.02 (0.47) | ||||
| Median PRS (range) | 3.21 (1.63-4.91) | 3.06 (1.61-4.70) | 3.19 (1.69-4.64) | 3.03 (1.52-4.63) | ||||
Risk of MM was adjusted for age, sex, and study. Risk of MGUS was adjusted for age and sex. Combined controls quintile ranges: Q1 = (1.52-1.66), Q2 = (1.66-2.93), Q3 = (2.93-3.16), Q4 = (3.16-3.43), Q5 = (3.43-4.91). Bold text indicates statistically significant estimates.
Q, quintile.