HLA-DR molecules encoded by DRB1*08:03 peptide binding assay for the whole ADAMTS13 molecule in silico
| . | ADAMTS13 peptide . | Domain . | Sequence (core sequence) . | %rank . | Predicted binding . |
|---|---|---|---|---|---|
| 1 | 101-115 | Metalloprotease | ERYVLTNLNIGAELL | 1.9 | Strong binder |
| 2 | 570-584 | Spacer | YVTFLTVTPNLTSVY | 1.1 | Strong binder |
| 3 | 914-928 | Thrombospondin-1 motif 5 | ELRFLCMDSALRVPV | 1.7 | Strong binder |
| 4 | 1324-1338 | CUB2 | GCRLFINVAPHARIA | 0.3 | Strong binder |
| 5 | 1334-1348 | CUB2 | HARIAIHALATNMGA | 1.6 | Strong binder |
| . | ADAMTS13 peptide . | Domain . | Sequence (core sequence) . | %rank . | Predicted binding . |
|---|---|---|---|---|---|
| 1 | 101-115 | Metalloprotease | ERYVLTNLNIGAELL | 1.9 | Strong binder |
| 2 | 570-584 | Spacer | YVTFLTVTPNLTSVY | 1.1 | Strong binder |
| 3 | 914-928 | Thrombospondin-1 motif 5 | ELRFLCMDSALRVPV | 1.7 | Strong binder |
| 4 | 1324-1338 | CUB2 | GCRLFINVAPHARIA | 0.3 | Strong binder |
| 5 | 1334-1348 | CUB2 | HARIAIHALATNMGA | 1.6 | Strong binder |
The underlined bold sequences indicate core sequence which is composed of 9 amino acids peptides and recognized by 9 pocket motifs of HLA-DR molecules.